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Sirt5 (NM_178848) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR204397L3V
- LentiORF®
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Lenti ORF particles, Sirt5 (Myc-DDK-tagged) - Mouse sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) (Sirt5), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Sirt5 (NM_178848) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 0610012J09Rik; 1500032M05Rik; AV001953 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_178848 |
| ORF Size | 933 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR204397).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_178848.3 |
| RefSeq Size | 1369 bp |
| RefSeq ORF | 933 bp |
| Locus ID | 68346 |
| Gene Summary | NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:23806337, PubMed:21908771, PubMed:22076378, PubMed:24315375, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:19410549, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (By similarity). Activates SHMT2 by mediating its desuccinylation (By similarity). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (PubMed:24315375). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox (PubMed:23085393).[UniProtKB/Swiss-Prot Function] |
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