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Tex264 (NM_011573) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR204389L3V
- LentiORF®
-
Lenti ORF particles, Tex264 (Myc-DDK-tagged) - Mouse testis expressed gene 264 (Tex264), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Tex264 (NM_011573) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | TEG-264 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_011573 |
| ORF Size | 930 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR204389).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011573.2, NP_035703.2 |
| RefSeq Size | 1906 bp |
| RefSeq ORF | 930 bp |
| Locus ID | 21767 |
| Gene Summary | Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins. Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure. Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN.[UniProtKB/Swiss-Prot Function] |
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