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Slamf7 (BC011154) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR204058L3V
- LentiORF®
-
Lenti ORF particles, Slamf7 (Myc-DDK-tagged) - Mouse SLAM family member 7 (cDNA clone MGC:19034 IMAGE:4168309), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Slamf7 (BC011154) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 19A, CS1, 19A24, CRACC |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC011154 |
| ORF Size | 882 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR204058).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC011154, AAH11154 |
| RefSeq Size | 1373 bp |
| RefSeq ORF | 884 bp |
| Locus ID | 75345 |
| Gene Summary | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (By similarity). Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (PubMed:19151721). May play a role in lymphocyte adhesion (By similarity). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (By similarity).[UniProtKB/Swiss-Prot Function] |
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