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Rad1 (NM_011232) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR203788L4V
- LentiORF®
-
Lenti ORF particles, Rad1 (GFP-tagged) - Mouse RAD1 homolog (S. pombe) (Rad1), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Rad1 (NM_011232) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | mRAD1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_011232 |
| ORF Size | 843 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR203788).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011232.2, NP_035362.2 |
| RefSeq Size | 1520 bp |
| RefSeq ORF | 843 bp |
| Locus ID | 19355 |
| Gene Summary | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (By similarity).[UniProtKB/Swiss-Prot Function] |
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