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Pcgf1 (NM_197992) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR203127L4V
- LentiORF®
-
Lenti ORF particles, Pcgf1 (GFP-tagged) - Mouse polycomb group ring finger 1 (Pcgf1), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Pcgf1 (NM_197992) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2010002K04Rik; AU024121; Nspc1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_197992 |
| ORF Size | 744 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR203127).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_197992.1, NP_932109.1 |
| RefSeq Size | 908 bp |
| RefSeq ORF | 744 bp |
| Locus ID | 69837 |
| Gene Summary | Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells.[UniProtKB/Swiss-Prot Function] |
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