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Kctd6 (NM_027782) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR202907L4V
- LentiORF®
-
Lenti ORF particles, Kctd6 (GFP-tagged) - Mouse potassium channel tetramerisation domain containing 6 (Kctd6), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Kctd6 (NM_027782) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 5430433B02Rik; AU044285 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_027782 |
| ORF Size | 714 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR202907).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_027782.1, NP_082058.1 |
| RefSeq Size | 1667 bp |
| RefSeq ORF | 714 bp |
| Locus ID | 71393 |
| Gene Summary | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu7 probably implicating CUL3-dependent proteasomal degradation.[UniProtKB/Swiss-Prot Function] |
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