Otulin (NM_001013792) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR202354L3V
- LentiORF®
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Lenti ORF particles, Fam105b (Myc-DDK-tagged) - Mouse family with sequence similarity 105, member B (Fam105b), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
Product Data | |
Product Name | Otulin (NM_001013792) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | C79097; Fam105b; m3Sapc; m7-1Sapc |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001013792 |
ORF Size | 1056 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR202354).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001013792.2, NP_001013814.2 |
RefSeq Size | 1491 bp |
RefSeq ORF | 1059 bp |
Locus ID | 432940 |
Gene Summary | Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:27523608, PubMed:29950720). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (By similarity). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:29950720). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608, PubMed:29950720). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling (By similarity).[UniProtKB/Swiss-Prot Function] |
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