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Cd3d (NM_013487) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR201480L4V
- LentiORF®
-
Lenti ORF particles, Cd3d (GFP-tagged) - Mouse CD3 antigen, delta polypeptide (Cd3d), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Cd3d (NM_013487) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | T3d |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_013487 |
| ORF Size | 522 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR201480).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_013487.2, NP_038515.2 |
| RefSeq Size | 1330 bp |
| RefSeq ORF | 522 bp |
| Locus ID | 12500 |
| Gene Summary | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly (PubMed:10935641). Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.[UniProtKB/Swiss-Prot Function] |
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