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Rpl11 (BC021402) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR201377L3V
- LentiORF®
-
Lenti ORF particles, Rpl11 (Myc-DDK-tagged) - Mouse ribosomal protein L11 (cDNA clone MGC:29111 IMAGE:4039711), 200ul, >10^7 TU/mL
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CNY 6,650.00
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Specifications
| Product Data | |
| Product Name | Rpl11 (BC021402) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2010203J19Rik |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC021402 |
| ORF Size | 501 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR201377).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC021402, AAH21402 |
| RefSeq Size | 599 bp |
| RefSeq ORF | 503 bp |
| Locus ID | 67025 |
| Gene Summary | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:21804542). Promotes nucleolar location of PML (PubMed:15195100).[UniProtKB/Swiss-Prot Function] |
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