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Myl2 (NM_010861) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR201346L3V
- LentiORF®
-
Lenti ORF particles, Myl2 (Myc-DDK-tagged) - Mouse myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Myl2 (NM_010861) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | MLC-2; MLC-2s/v; MLC-2v; Mlc2v; Mylpc |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_010861 |
| ORF Size | 501 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR201346).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010861.2, NP_034991.2 |
| RefSeq Size | 633 bp |
| RefSeq ORF | 501 bp |
| Locus ID | 17906 |
| Gene Summary | Contractile protein that plays a role in heart development and function (PubMed:10409661). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) (PubMed:22426213, PubMed:16908724, PubMed:10409661). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (PubMed:9422794).[UniProtKB/Swiss-Prot Function] |
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