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Hscb (NM_153571) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR201219L4V
- LentiORF®
-
Lenti ORF particles, Hscb (GFP-tagged) - Mouse HscB iron-sulfur cluster co-chaperone homolog (E. coli) (Hscb), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Hscb (NM_153571) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI325508; AW049829; Hsc20 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_153571 |
| ORF Size | 480 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR201219).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_153571.1, NP_705799.1 |
| RefSeq Size | 825 bp |
| RefSeq ORF | 705 bp |
| Locus ID | 100900 |
| Gene Summary | Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT.[UniProtKB/Swiss-Prot Function] |
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