Synaptopodin 2 (SYNPO2) (NM_001286754) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001286754, the custom clone sequence may differ by one or more nucleotides ATGGTTACACAGATTCGAAATCAGAGCAAAGCCTCTGGGTCTGGGCTCTGTGAGGGAGATGAAGTGGTTT CCATCAATGGCAACCCTTGTGCAGATCTCACCTACCCTGAAGTCATCAAGCTCATGGAAAGCATAACAGA CTCTCTCCAAATGCTCATCAAAAGACCATCCAGTGGAATAAGTGAGGCTTTGATATCTGAAAATGAAAAC AAAAACCTCGAGCATCTCACACATGGGGGTTATGTGGAAAGTACCACCCTGCAGATTCGACCGGCCACAA AGACCCAGTGCACAGAATTCTTCCTCGCCCCTGTCAAGACTGAAGTTCCCCTAGCTGAGAACCAAAGAAG TGGTCCCGACTGTGCAGGCAGCTTGAAAGAAGAAACAGGCCCGAGCTACCAAAGGGCTCCCCAAATGCCT GACTCCCAAAGAGGACGCGTGGCAGAAGAGCTGATCTTAAGGGAGAAGGTAGAAGCGGTACAGCCTGGGC CTGTGGTTGAGCTGCAACTGTCCCTTTCACAGGAGAGACATAAGGGCGCTAGTGGCCCTTTAGTGGCTCT CCCGGGAGCTGAAAAATCTAAGTCTCCTGACCCAGACCCTAACTTGTCACATGACAGGATTGTCCACATA AATTCGATCCCTACTAATGAGAAAGCAGACCCTTTCCTGAGGTCCAGCAAGATAATCCAGATCTCCAGTG GCAGAGAGTTGAGAGTGATCCAGGAAAGTGAAGCAGGAGATGCGGGACTGCCCCGGGTGGAAGTGATCCT CGACTGCTCTGACAGGCAGAAGACAGAAGGGTGCAGGCTTCAGGCAGGAAAGGAGTGTGTGGATTCTCCA GTGGAAGGAGGGCAGTCAGAAGCACCTCCTTCTCTGGTATCCTTTGCCGTCTCATCAGAAGGCACAGAGC AGGGAGAAGATCCACGCTCGGAAAAAGATCACAGCAGACCTCACAAGCACCGAGCGCGGCATGCACGGCT CAGGAGGAGTGAAAGCCTGTCAGAAAAACAAGTGAAGGAAGCAAAATCTAAATGCAAAAGCATTGCCCTT CTTCTAACGGATGCTCCCAACCCCAACTCCAAGGGGGTGTTGATGTTTAAGAAGCGACGTCGGAGGGCCA GGAAATACACCCTAGTTAGCTACGGTACTGGCGAGCTTGAGCGAGAGGCGGACGAGGAGGAAGAAGGTGA CAAGGAGGATACATGTGAAGTAGCATTTCTTGGTGCAAGCGAATCAGAGGTGGATGAAGAGTTATTGTCT GACGTTGACGACAACACACAAGTTGTGAACTTTGACTGGGATTCTGGACTGGTGGACATTGAAAAGAAAC TGAACAGAGGGGACAAGATGGAGATGTTACCAGACACCACAGGCAAGGGAGCCCTCATGTTTGCCAAGAG GAGGGAGAGAATGGATCAGATCACAGCCCAAAAAGAAGAGGACAAGGTAGGTGGAACGCCAAGCAGAGAA CAAGATGCTGCCCAGACCGATGGCCTGAGAACCACGACTTCTTACCAAAGAAAGGAGGAAGAGTCGGTAA GAACGCAGAGCTCTGTGAGCAAAAGCTACATCGAGGTGAGTCATGGTCTTGGCCATGTTCCCCAACAGAA TGGCTTCAGTGGGACATCTGAGACAGCAAACATCCAGAGGATGGTCCCCATGAATAGAACGGCCAAACCC TTCCCAGGGTCTGTGAATCAGCCAGCTACCCCCTTCTCGCCAACCCGAAACATGACGAGTCCCATTGCTG ACTTTCCTGCACCTCCACCTTACTCTGCAGTCACTCCTCCCCCTGACGCCTTCTCCAGAGGGGTTTCAAG TCCGATTGCTGGCCCAGCACAGCCCCCTCCATGGCCCCAGCCTGCCCCGTGGTCCCAGCCAGCCTTTTAC GATTCGTCTGAGCGAATAGCTTCCCGAGATGAGAGGATCTCAGTGCCAGCAAAAAGAACAGGAATATTGC AGGAGGCCAAAAGGAGAAGCACGACAAAACCCATGTTTACTTTTAAAGAGCCCAAAGTAAGCCCAAATCC TGAACTCTTGTCACTCCTTCAAAATTCAGAAGGCAAACGGGGCACTGGAGCTGGAGGTGATTCCGGACCG GAAGAAGACTACCTCAGCTTGGGGGCAGAGGCTTGTAATTTCATGCAAAGCTCCTCTGCCAAACAAAAGA CCCCTCCTCCTGTTGCTCCAAAACCTGCAGTCAAGTCCTCATCCTCCCAACCAGTAACTCCAGTTTCCCC AGTCTGGTCTCCAGGAGTGGCTCCCACCCAACCTCCTGCCTTCCCCACATCCAACCCATCAAAGGGCACC GTTGTCTCCTCCATCAAAATAGCCCAGCCTTCTTACCCTCCTGCCCGGCCTGCAAGTACTTTGAACGTGG CTGGTCCCTTCAAAGGACCACAAGCAGCAGTAGCCAGTCAGAATTACACACCCAAACCAACAGTTTCCAC ACCAACAGTCAATGCTGTTCAGCCTGGTGCAGTGGGACCATCCAATGAGCTTCCAGGAATGAGTGGGAGA GGAGCTCAGCTCTTTGCTAAAAGGCAGTCGAGAATGGAGAAGTATGTGGTCGATTCAGACACGGTGCAGG CCCACGCTGCTCGAGCTCAGTCTCCCACTCCATCTCTCCCGGCCAGTTGGAAGTACTCCTCCAATGTCCG AGCACCTCCTCCTGTGGCCTATAATCCTATCCACTCGCCGTCTTACCCACTGGCTGCTCTCAAGTCTCAG CCATCAGCTGCACAGCCCTCCAAAATGGGCAAGAAAAAGGGAAAGAAACCCCTCAATGCATTAGATGTCA TGAAGCACCAACCGTATCAGCTCAATGCATCCTTGTTTACTTTCCAACCTCCAGATGCAAAGGATGGCCT CCCCCAGAAGTCATCAGTCAAGGTCAATTCAGCCCTGGCCATGAAGCAAGCTCTTCCTCCCCGGCCAGTG AATGCTGCCTCACCTACGAATGTGCAGGCTTCGTCAGTGTACTCGGTACCAGCCTATACCTCTCCTCCTT CCTTCTTTGCAGAGGCCTCCTCACCAGTCAGTGCATCCCCAGTGCCTGTGGGCATTCCCACCTCGCCAAA GCAAGAATCAGCCTCATCATCTTATTTTGTGGCACCAAGGCCAAAGTTCTCAGCCAAGAAAAGTGGTGTC ACAATTCAGGAGAGTGGGCGCTCCCTTTCTCTTCCTGGAAGATCAGTCCCACCCCCCATTTCTACATCTC CTTGGGTATACCAGCCTACTTATAGTTACTCTAGTAAACCAACCGATGGACTAGAGAAAGCAAACAAGAG ACCAACTCCTTGGGAAGCAGCAGCAAAGTCTCCTCTCGGTCTAGTGGATGATGCTTTCCAACCCAGAAAC ATCCAGGAATCCATTGTGGCAAATGTGGTTTCAGCAGCTCGGAGGAAGGTGCTTCCAGGGCCTCCAGAGG ATTGGAATGAAAGACTGTCCTATATTCCTCAAACCCAGAAGGCCTATATGGGCTCATGTGGAAGGCAAGA GTATAATGTCACAGCCAATAATAATATGTCCACCACCTCCCAATATGGTTCACAGTTGCCATATGCATAT TATAGGCAGGCTTCAAGAAATGATTCTGCAATCATGTCCATGGAAACCAGGTCTGATTACTGTCTTCCAG TAGCTGATTACAACTACAACCCACACCCAAGGGGATGGAGACGCCAAACATGA
Restriction Sites	SgfI-NotI
ACCN	NM_001286754
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001286754.1, NP_001273683.1
RefSeq Size	7263 bp
RefSeq ORF	3693 bp
Locus ID	171024
UniProt ID	Q9UMS6
Gene Summary	Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (4) contains an alternate 5'-terminal exon, compared to variant 1. The encoded isoform (d) has a shorter and distinct N-terminus, compared to isoform a.

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