UBN1 (NM_001288656) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	VT; VT4
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001288656, the custom clone sequence may differ by one or more nucleotides ATGTCGGAGCCCCACAGGGTCCAGTTCACCTCTCTCCCAGGTTCCCTGAATCCTGCGTTTTTGAAGAAGT CCCGGAAGGAGGAGGCTGGGGCAGGAGAACAGCATCAGGACTGTGAGCCGGCTGCAGCAGCTGTTCGGAT TACACTCACCCTCTTTGAACCAGATCACAAACGCTGCCCAGAGTTCTTCTACCCAGAGCTGGTGAAGAAT ATCCGAGGGAAGGTAAAAGGCCTTCAGCCTGGAGATAAGAAGAAAGATCTGTCAGATCCTTTCAATGACG AAGAAAAGGAAAGGCATAAAGTAGAGGCCCTTGCCCGAAAATTTGAAGAAAAATACGGTGGAAAGAAACG TAGAAAAGACCGAATACAGGACTTGATCGATATGGGGTATGGTTATGATGAATCCGACTCCTTCATCGAT AACTCTGAGGCGTATGATGAGCTTGTTCCTGCTTCTTTGACTACGAAGTATGGAGGATTTTACATTAACT CGGGAACCCTGCAGTTTAGACAAGCATCAGAGTCTGAAGATGACTTCATTAAAGAAAAGAAGAAAAAATC TCCAAAGAAGCGGAAGTTGAAGGAAGGTGGTGAGAAGATAAAGAAGAAGAAAAAAGATGACACTTATGAC AAGGAGAAGAAATCGAAAAAGTCCAAGTTTTCCAAAGCCGGCTTCACAGCCCTCAATGCCAGTAAGGAGA AGAAGAAGAAGAAATATTCTGGGGCTTTAAGCGTTAAAGAGATGCTAAAGAAATTTCAGAAAGAGAAAGA GGCTCAGAAAAAAAGGGAGGAGGAGCATAAGCCTGTTGCGGTCCCATCAGCGGAAGCTCAGGGCCTGCGG GAACTGGAGGGTGCCTCTGACCCCTTGCTCTCACTCTTTGGCTCTACTTCTGACAACGACTTGCTCCAGG CGGCCACTGCCATGGACTCGCTGACGGATTTGGACTTGGAGCATCTGCTCAGTGAGTCTCCAGAAGGAAG TCCCTTCCGAGATATGGATGATGGAAGTGATTCCCTTGGGGTGGGATTGGACCAGGAATTCAGGCAGCCC TCTTCTCTCCCCGAAGGCCTGCCAGCACCCCTGGAGAAGCGCGTTAAGGAGCTGGCTCAGGCTGCCAGAG CTGCTGAGGGGGAGAGCAGACAGAAGTTCTTCACCCAGGATATTAATGGAATCCTATTAGACATAGAGGC GCAGACTCGGGAGCTGAGCAGTCAGGTCCGCTCTGGGGTGTATGCCTATCTTGCGTCATTCCTGCCCTGC AGCAAGGATGCCCTGCTCAAGCGTGCTCGGAAACTTCACCTCTATGAACAGGGGGGCCGTCTGAAGGAGC CTCTCCAGAAGCTCAAGGAAGCCATTGGCAGGGCGATGCCAGAGCAGATGGCCAAGTACCAGGACGAATG CCAGGCACACACGCAGGCAAAGGTTGCCAAGATGCTGGAAGAGGAGAAAGACAAGGAGCAGAGGGACCGG ATTTGTTCGGATGAGGAAGAAGATGAAGAAAAAGGGGGCAGGAGGATAATGGGACCTCGGAAGAAGTTCC AATGGAATGATGAGATCAGGGAGCTACTGTGCCAGGTGGTGAAGATCAAACTGGAGAGCCAGGACCTGGA GAGGAACAACAAAGCCCAGGCTTGGGAGGACTGTGTGAAGGGCTTTCTGGATGCGGAAGTCAAGCCCCTC TGGCCCAAAGGCTGGATGCAGGCCAGAACTCTGTTTAAGGAGAGCAGACGAGGCCATGGGCACCTGACTT CAATCCTGGCCAAGAAGAAAGTTATGGCCCCTTCTAAAATCAAGGTGAAGGAATCGTCTACGAAGCCTGA TAAAAAGGTTTCTGTCCCATCAGGACAGATTGGTGGCCCCATTGCTTTGCCCTCAGATCACCAAACAGGA GGCCTGAGTATTGGGGCCTCGAGCAGGGAGCTCCCATCCCAGGCATCGGGCGGCCTTGCTAACCCTCCTC CTGTCAACCTGGAGGACTCATTGGATGAAGACTTGATCCGCAATCCAGCCTCCTCGGTGGAAGCCGTGTC CAAGGAATTGGCTGCATTGAATAGCAGAGCAGCTGGGAACTCTGAATTCACACTGCCTGCACCCTCAAAA GCACCTGCAGAAAAAGTTGGAGGCGTTTTATGTACAGAAGAAAAAAGGAACTTTGCGAAGCCTAGTCCTT CTGCTCCACCACCAGCTAGCTCTCTGCAGTCACCCCTCAATTTTCTGGCAGAACAGGCTCTGGCACTGGG GCAGTCCTCTCAGGAGAAAAAACCAGAGAGTTCTGGCTACAAAGAGCTGTCCTGCCAGGCTCCCCTCAAT AAGGGCCTGCCAGAAGTACATCAGTCCAAAGCTAAGCACCACAGCTTGCCACGGACGTCTCACGGGCCCC AAGTGGCAGTTCCTGTGCCTGGCCCCCAGGTCAAAGTCTTTCATGCCGGCACTCAGCAGCAGAAAAACTT CACGCCCCCATCTCCATTTGCCAATAAGCTCCAAGGCCCAAAGGCTTCTCCCACACAGTGTCATCGTTCC CTCCTGCAGTTAGTGAAGACAGCGGCCAAAGGCCAGGGCTTCCATCCCTCTGCACCAGCCACCTCAGGAG GCCTGTCAGCCTCCAGCAGCAGCTCTCACAAGACCCCAGCCTCGTCCTCTTCTGCCCTGAGCCATCCAGC AAAGCCACATTCAGTCAGCTCTGCAGGCTCATCTTACAAGAATAATCCCTTTGCCAGCTCAATCTCCAAA CATGGGGTTTCTTCTGGCAGCTCTTCCTCGGGAGGAACACCAGTCCAGAGTTCTGTTTCTGGGAGCCTGG TCCCTGGCATACAGCCTCCCTCCGTGGGACAGGCCACCAGCCGACCCGTCCCAAGTTCAGCAGGGAAAAA AATGCCTGTTTCCCAGAAGTTGACTCTGGTAGCCCCTCCAGGCGGTCCAAACGGAGATTCCAGTGGTGGG ACCCAGGGAGTGGCAAAGTTGCTGACCTCGCCGTCCCTAAAGCCCTCTGCAGTTAGTAGTGTGACATCGT CTACCTCCTTGTCAAAAGGAGCGAGTGGGACTGTGCTGCTGGCCGGCTCCTCTTTGATGGCTTCACCCTA CAAATCCAGCAGCCCAAAGCTGTCTGGGGCCATGAGCTCGAACTCCTTGGGAATTATAACCCCTGTCCCT ATTCCTGTCCATGTGCTCTCCTTCAGCGCTGACTCCTCTGCCAAAGCAGGGGTCTCCAAGGATGCCATCG TCACAGGCCCTGCCCCCGGGTCCTTCCACCATGGCCTTGGCCACAGTGCTTCTCAGCTTCACGGGAAAGG GCCTGCTGTACCACGGAAATTGTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001288656
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001288656.1, NP_001275585.1
RefSeq Size	5652 bp
RefSeq ORF	3315 bp
Locus ID	29855
UniProt ID	Q9NPG3
Gene Summary	Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016] Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 3' coding region, compared to variant 2. The encoded isoform (b) is shorter, compared to isoform a.

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