FARP2 (NM_001282983) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	FIR; FRG; PLEKHC3
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >SC337089 representing NM_001282983. Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGGGGAGATAGAAGGAACATACAGAGTCCTGCAGACTGCAGGGATGCGCTTGGGTGCCCAGACCCCT GTGGGAGTTAGCACCCTTGAGCCTGGGCAGACTCTCTTGCCCAGAATGCAAGAGAAGCACCTGCACCTC AGAGTAAAGCTGCTGGACAACACCATGGAAATATTTGACATTGAGCCTAAATGCGATGGCCAGGTATTA CTGACACAAGTGTGGAAGCGTTTAAACCTGGTAGAATGTGACTACTTCGGGATGGAGTTTCAAAATACT CAGTCCTACTGGATTTGGCTTGAACCTATGAAACCCATCATTAGGCAAATACGAAGGCCAAAGAATGTG GTGCTTCGCCTAGCTGTAAAATTTTTTCCACCTGATCCTGGTCAGCTACAAGAAGAATATACAAGATAC TTGTTTGCCTTGCAACTTAAGAGAGACCTGCTGGAAGAGCGTTTGACCTGTGCTGACACCACAGCGGCC CTTCTCACGTCCCATCTCCTGCAGTCGGAAATAGGAGATTACGATGAAACGCTGGACCGAGAGCACCTC AAAGTGAACGAGTATTTGCCTGGCCAGCAGCACTGCCTTGAGAAGATACTAGAATTCCATCAGAAGCAC GTGGGCCAGACACCTGCTGAGTCGGATTTCCAGGTGCTCGAAATTGCTCGAAAGTTGGAAATGTACGGC ATCAGATTTCACATGGCTTCTGACAGGGAAGGAACCAAGATTCAACTGGCAGTTTCCCACATGGGTGTA CTCGTGTTCCAGGGCACCACCAAAATCAACACTTTCAACTGGTCCAAGGTCCGTAAACTAAGCTTCAAG AGGAAAAGATTTCTTATCAAACTTCATCCAGAGGTTCATGGACCTTACCAGGACACATTAGAATTTTTG TTGGGTAGTAGAGATGAATGTAAGAACTTCTGGAAGATTTGTGTGGAGTATCACACCTTTTTTAGACTT TTGGACCAACCTAAGCCAAAAGCAAAAGCCGTCTTCTTCAGCCGGGGCTCCTCCTTCAGATACAGTGGA AGAACTCAGAAACAACTAGTAGATTATTTCAAAGACAGTGGAATGAAGAGAATTCCATATGAAAGAAGG CACAGCAAGACCCACACGTCCGTTCGAGCTCTGACTGCAGACCTACCAAAACAGAGCATCTCATTCCCC GAGGGATTGAGGACTCCTGCCTCCCCATCTTCAGCGAATGCCTTTTACTCGCTCTCTCCCTCCACTCTG GTCCCCTCTGGCCTGCCAGAGTTTAAGGACAGCAGCAGCTCCCTCACAGATCCCCAGGTTTCCTACGTC AAGAGTCCAGCTGCAGAGAGGCGCAGTGGAGCAGTGGCTGGAGGCCCCGACACACCATCGGCCCAGCCC CTCGGGCCCCCCGCACTCCAGCCTGGTCCAGGCCTTTCCACGAAGAGTCCTCAGCCTTCTCCCTCCAGC CGGAAGAGCCCCCTGAGTCTGAGCCCTGCATTTCAGGTGCCTTTGGGCCCAGCTGAACAGGGCTCATCC CCACTCCTGAGCCCTGTCCTCAGTGATGCTGGCGGAGCCGGGATGGACTGCGAGGAGCCCAGACACAAG CGCGTGCCTGCAGACGAGGCCTACTTCATAGTCAAAGAGATTCTCGCTACAGAACGAACATACCTCAAG GATTTAGAAGTTATTACCGTGTGGTTCCGCAGCGCAGTGGTGAAGGAGGACGCCATGCCTGCGACTCTG ATGACGCTGCTCTTCTCCAACATCGATCCCATCTATGAGTTCCACAGAGGCTTCCTGCGCGAGGTGGAG CAGAGGCTGGCACTCTGGGAAGGGCCCTCCAAAGCCCACACAAAAGGCAGTCATCAACGAATCGGGGAC ATCCTGCTCAGGAACATGCGCCAGTTAAAGGTGTTCCAGCTCCACGAAGGGCATGTAGCAGGGGTCACA AAAATGGAGTAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites	SgfI-MluI
ACCN	NM_001282983
Insert Size	1944 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001282983.1
RefSeq Size	2651 bp
RefSeq ORF	1944 bp
Locus ID	9855
UniProt ID	O94887
Protein Pathways	Adherens junction
MW	73.3 kDa
Gene Summary	Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks several 3' exons but includes a novel 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.

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