SLC22A17 (NM_001289050) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >SC335211 representing NM_001289050. Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGATCACCGCTCCCTGCATCCTCTTCCTGTTTTATGGCTGGCCTGGTTTGTTCCTGGAGTCCGCACGG TGGCTGATAGTGAAGCGGCAGATTGAGGAGGCTCAGTCTGTGCTGAGGATCCTGGCTGAGCGAAACCGG CCCCATGGGCAGATGCTGGGGGAGGAGGCCCAGGAGGCCCTGCAGGACCTGGAGAATACCTGCCCTCTC CCTGCAACATCCTCCTTTTCCTTTGCTTCCCTCCTCAACTACCGCAACATCTGGAAAAATCTGCTTATC CTGGGCTTCACCAACTTCATTGCCCATGCCATTCGCCACTGCTACCAGCCTGTGGGAGGAGGAGGGAGC CCATCGGACTTCTACCTGTGCTCTCTGCTGGCCAGCGGCACCGCAGCCCTGGCCTGTGTCTTCCTGGGG GTCACCGTGGACCGATTTGGCCGCCGGGGCATCCTTCTTCTCTCCATGACCCTTACCGGCATTGCTTCC CTGGTCCTGCTGGGCCTGTGGGATTATCTGAACGAGGCTGCCATCACCACTTTCTCTGTCCTTGGGCTC TTCTCCTCCCAAGCTGCCGCCATCCTCAGCACCCTCCTTGCTGCTGAGGTCATCCCCACCACTGTCCGG GGCCGTGGCCTGGGCCTGATCATGGCTCTAGGGGCGCTTGGAGGACTGAGCGGCCCGGCCCAGCGCCTC CACATGGGCCATGGAGCCTTCCTGCAGCACGTGGTGCTGGCGGCCTGCGCCCTCCTCTGCATTCTCAGC ATTATGCTGCTGCCGGAGACCAAGCGCAAGCTCCTGCCCGAGGTGCTCCGGGACGGGGAGCTGTGTCGC CGGCCTTCCCTGCTGCGGCAGCCACCCCCTACCCGCTGTGACCACGTCCCGCTGCTTGCCACCCCCAAC CCTGCCCTCTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites	SgfI-MluI
ACCN	NM_001289050
Insert Size	909 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001289050.1
RefSeq Size	2027 bp
RefSeq ORF	909 bp
Locus ID	51310
UniProt ID	Q8WUG5
Protein Families	Druggable Genome, Transmembrane
MW	32.7 kDa
Gene Summary	Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of a coding exon and an alternate in-frame splice junction at the 3' end of another exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.