ALDH1L1 (NM_001270364) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	10-fTHF; 10-FTHFDH; FDH; FTHFD
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332908 representing NM_001270364. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCAGGTCCTTCCAACCCTCCTGCTACCATGAAGATTGCAGTGATTGGACAGAGCCTGTTTGGCCAG GAAGTTTACTGCCACCTGAGGAAGGAGGGCCACGAAGTGGTGGGTGTGTTCACTGTTCCAGACAAGGAT GGAAAGGCCGACCCCCTGGGTCTGGAAGCTGAGAAGGATGGAGTGCCGGTATTCAAGTACTCCCGGTGG CGTGCAAAAGGACAGGCTTTGCCTGATGTGGTGGCAAAATACCAGGCTTTGGGGGCCGAGCTCAACGTC CTGCCCTTCTGCAGCCAATTCATCCCCATGGAGATAATCAGTGCCCCCCGGCATGGCTCCATCATCTAT CACCCGTCACTGCTCCCTAGGCACCGAGGGGCCTCGGCCATCAACTGGACCCTCATTCACGGAGATAAG AAAGGGGGGTTTTCCATCTTCTGGGCGGATGATGGTCTGGACACCGGAGACCTGCTGCTGCAGAAGGAG TGTGAGGTGCTCCCGGACGACACCGTGAGCACGCTGTACAACCGCTTCCTCTTCCCTGAAGGCATCAAA GGGATGGTGCAGGCCGTGAGGCTGATCGCTGAGGGCAAAGCCCCCAGACTCCCTCAGCCTGAGGAAGGA GCCACCTATGAGGGGATTCAGAAGAAGGAGACAGCCAAGATCAACTGGGACCAGCCGGCAGAGGCCATT CACAACTGGATCCGCGGGAACGACAAGGTGCCGGGAGCCTGGACAGAGGCCTGTGAACAGAAACTGACA TTTTTCAACTCAACGCTGAACACTTCAGGCCTGGTGCCCGAGGGAGACGCTTTGCCCATCCCAGGAGCC CATCGGCCAGGGGTGGTCACCAAAGCAGGACTCATCCTCTTTGGGAATGATGACAAAATGCTGCTGGTG AAGAATATTCAGCTGGAGGATGGCAAAATGATCCTGGCCTCGAACTTCTTTAAGGGGGCAGCCAGCAGT GTCCTTGAGCTGACAGAGGCAGAGCTGGTTACTGCGGAGGCTGTGCGGAGTGTTTGGCAGCGGATCCTC CCCAAAGTCCTGGAGGTTGAAGACTCCACTGATTTCTTCAAGTCAGGGGCCGCGTCTGTGGACGTTGTG AGGCTGGTGGAGGAAGTGAAGGAGCTGTGTGATGGCCTGGAGTTAGAAAATGAAGATGTGTACATGGCA TCCACCTTTGGGGACTTCATCCAGCTGTTAGTGAGGAAGCTGCGAGGGGACGATGAGGAGGGCGAGTGC AGCATTGACTACGTGGAAATGGCAGTGAACAAGCGCACTGTCCGCATGCCCCACCAGCTCTTCATTGGG GGGGAGTTCGTGGATGCCGAGGGCGCCAAGACCTCTGAGACCATCAATCCCACCGATGGAAGTGTCATC TGCCAGGTATCCCTGGCCCAAGTCACCGACGTCGACAAGGCAGTGGCCGCAGCCAAGGATGCCTTTGAG AATGGACGGTGGGGGAAGATCAGTGCGCGGGACCGGGGCCGGCTGATGTACAGGTTGGCAGATCTCATG GAGCAGCACCAGGAGGAGCTGGCCACCATTGAGGCCCTGGATGCGGGTGCCGTCTACACGCTGGCCCTG AAGACCCACGTGGGCATGTCCATCCAGACCTTCCGCTACTTTGCTGGCTGGTGTGACAAGATCCAGGGC TCCACCATCCCCATCAACCAGGCCAGACCCAACCGCAACCTGACCTTGACCAGGAAGGAGCCTGTTGGG GTTTGTGGCATCATCATCCCCTGGAACTATCCCCTGATGATGCTGTCCTGGAAGACAGCTGCCTGCCTG GCTGCCGGGAACACAGTGGTGATCAAGCCTGCTCAGGTGACCCCACTCACAGCCTTGAAGTTTGCAGAG CTGACATTAAAGGCCGGCATTCCCAAAGGTGTGGTTAACGTCCTCCCAGGATCTGGCTCCCTGGTCGGC CAGAGACTCTCAGACCATCCTGATGTGAGGAAAATCGGGTTCACAGGCTCCACAGAGGTGGGCAAGCAC ATCATGAAAAGCTGTGCCATAAGTAACGTGAAGAAGGTGTCCCTGGAACTGGGCGGGAAGTCACCCCTC ATCATCTTTGCTGACTGTGACCTCAACAAGGCTGTGCAGATGGGGATGAGTTCTGTTTTCTTCAACAAA GGAGAGAATTGCATTGCAGCAGGCCGACTCTTTGTGGAGGACTCCATTCATGATGAGTTCGTGCGGAGA GTGGTAGAAGAGGTGCGGAAGATGAAGGTGGGCAACCCGCTGGACAGGGACACCGACCACGGGCCGCAG AATCACCATGCCCACCTTGTGAAGCTGATGGAGTACTGCCAGCATGGCGTGAAGGAAGGGGCCACACTG GTCTGCGGCGGGAATCAGGTCCCTCGGCCAGGGTTCTTCTTTGAGCCAACTGTTTTCACAGACGTGGAA GACCACATGTTCATAGCCAAGGAGGAGTCCTTCGGGCCTGTCATGATCATCTCTCGGTTTGCTGATGGG GACTTGGATGCCGTGCTGTCTCGGGCCAATGCCACGGAATTTGGCCTGGCTTCTGGTGTCTTCACCAGG GACATCAACAAGGCCCTGTATGTCAGTGACAAGCTCCAGGCAGGCACTGTGTTTGTCAACACGTACAAC AAGACCGACGTGGCCGCTCCCTTCGGAGGATTCAAACAGTCTGGATTTGGCAAAGATCTAGGAGAGGCG GCTCTGAACGAGTACCTGCGGGTCAAGACAGTGACCTTCGAATACTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001270364
Insert Size	2739 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001270364.1
RefSeq Size	3204 bp
RefSeq ORF	2739 bp
Locus ID	10840
UniProt ID	O75891
Protein Families	Druggable Genome
Protein Pathways	One carbon pool by folate
MW	99.8 kDa
Gene Summary	The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] Transcript Variant: This variant (1) encodes the longest protein (isoform 1).

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