BCAR3 (NM_001261409) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	AND-34; MIG7; NSP2; SH2D3B
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332762 representing NM_001261409. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCA TCCATGGACCTTCTGAGCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCT ATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTCCTCCCATAAGGTCCTGTGATGACTTCAGTCAC ATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATGGCATCCAGGAG AGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTG GAATATGTGAAGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTG GAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGA CAGGTGTCTGAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACTCTCTGTCCAGCCCTGGG AACTTTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGA CTCAGCGAGGCCTACAGCCGCGTGCAGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTG GTGCGCTGCTACGTGGGCAACCGCCGGCCCATCTCCCAGCAGAGTGGCGCCATCATCTTCCAGCCCATC AACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCTCCCCAGGCCAGGCCCGGGAGGGC AGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCACCATGGGTGGCGTCCAGGCCCGA GAGCAGAATTTGCCCAGGGGAAACCTCCTCAGAAACAAAGAAAAGAGTGGTAGCCAGCCCGCCTGCCTG GATCACATGCAGGACAGAAGAGCCTTGTCCCTCAAAGCCCACCAGTCAGAGAGCTACCTGCCGATTGGC TGCAAGCTGCCACCTCAGTCCTCGGGTGTGGACACAAGCCCCTGCCCAAACTCACCTGTGTTCAGGACG GGAAGCGAGCCTGCCCTGAGCCCAGCAGTGGTTCGGAGGGTCTCCTCAGACGCCAGGGCTGGGGAGGCG CTGAGGGGATCAGACAGTCAACTGTGCCCTAAGCCCCCGCCTAAGCCCTGCAAGGTGCCGTTCCTCAAG GTTCCCTCGTCTCCCTCTGCCTGGCTCAACTCAGAGGCCAACTACTGTGAACTGAACCCAGCGTTTGCC ACAGGCTGCGGCAGGGGAGCAAAGCTACCCTCATGTGCCCAGGGAAGCCACACAGAACTGCTCACAGCC AAGCAGAATGAGGCGCCAGGTCCCCGGAACTCTGGCGTCAACTACTTGATCCTTGATGATGATGACAGG GAAAGACCTTGGGAACCTGCGGCAGCTCAGATGGAGAAGGGGCAGTGGGACAAGGGCGAGTTTGTGACG CCCCTCCTGGAGACTGTCTCCTCCTTCAGGCCCAACGAGTTTGAGTCAAAGTTCCTTCCCCCTGAGAAT AAGCCCCTGGAAACAGCAATGTTGAAACGTGCAAAAGAACTGTTCACCAACAACGACCCCAAGGTCATC GCCCAGCACGTACTGAGCATGGACTGCAGGGTTGCTAGGATACTTGGAGTCTCTGAAGAGATGAGGAGG AACATGGGGGTGAGCTCAGGCCTGGAACTCATTACCTTGCCTCACGGACACCAGCTGCGCCTGGACATA ATTGAAAGACACAACACAATGGCCATCGGCATTGCAGTGGACATTCTGGGATGCACGGGCACTTTGGAG GACCGAGCGGCCACTCTGAGTAAGATCATCCAGGTGGCGGTGGAACTGAAGGATTCCATGGGGGACCTC TATTCCTTCTCAGCTCTCATGAAAGCCCTGGAAATGCCACAGATCACAAGGTTAGAAAAGACGTGGACT GCTCTGCGGCACCAGTACACCCAAACTGCCATTCTCTATGAGAAACAGCTGAAGCCCTTCAGCAAACTC CTGCATGAAGGCAGAGAGTCCACATGTGTTCCCCCAAACAATGTATCAGTCCCACTGCTGATGCCGCTT GTGACGTTAATGGAGCGCCAGGCTGTGACTTTTGAAGGAACCGACATGTGGGAAAAAAACGACCAGAGC TGTGAAATCATGCTGAACCATTTGGCAACAGCGCGATTCATGGCCGAGGCTGCAGACAGCTACCGGATG AATGCTGAGAGGATCCTGGCAGGTTTTCAACCAGATGAAGAAATGAATGAAATCTGCAAGACTGAATTT CAAATGCGATTGCTATGGGGCAGCAAAGGTGCACAAGTCAATCAGACAGAGAGATATGAGAAATTCAAC CAGATTTTAACTGCCCTCTCGCGTAAATTGGAACCTCCTCCTGTAAAGCAGGCAGAGCTTTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001261409
Insert Size	2478 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001261409.1
RefSeq Size	3226 bp
RefSeq ORF	2478 bp
Locus ID	8412
UniProt ID	O75815
Protein Families	Druggable Genome
MW	92.6 kDa
Gene Summary	Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).

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