CACNA1F (NM_001256790) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	AIED; Cav1.4; Cav1.4alpha1; COD3; COD4; CORDX; CORDX3; CSNB2; CSNB2A; CSNBX2; JM8; JMC8; OA2
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332474 representing NM_001256790. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGTCGGAATCTGAAGGCGGGAAAGGTGAGAGAATCCTTCCATCCCTGCAGACCCTTGGAGCAAGCATC GTGGAGTGGAAGCCCTTCGACATCCTCATCCTGCTGACCATCTTTGCCAACTGCGTGGCCCTGGGAGTT TACATCCCCTTCCCTGAGGACGACTCCAACACTGCCAACCACAACCTGGAGCAGGTGGAGTACGTATTC CTGGTGATTTTCACTGTGGAGACGGTGCTCAAGATCGTGGCCTACGGGCTGGTGCTCCACCCCAGCGCC TACATCCGCAATGGCTGGAACCTACTCGACTTCATCATCGTCGTGGTCGGGCTGTTCAGCGTTCTGCTG GAGCAGGGCCCCGGACGGCCAGGCGACGCCCCGCACACCGGGGGAAAGCCAGGAGGCTTCGATGTGAAG GCATTGAGGGCGTTTCGGGTGCTGCGGCCACTGAGGCTGGTGTCTGGGGTCCCGAGCCTGCACATAGTG CTCAATTCCATCATGAAGGCTCTGGTGCCGCTGCTGCACATTGCACTGCTCGTGCTCTTCGTCATCATC ATTTATGCCATCATTGGGCTCGAGCTGTTCCTTGGACGAATGCACAAGACGTGCTACTTCCTGGGATCC GACATGGAAGCGGAGGAGGACCCATCGCCCTGTGCGTCTTCGGGATCAGGGCGTGCGTGCACGCTGAAC CAGACTGAGTGCCGCGGGCGCTGGCCAGGGCCCAATGGAGGCATCACCAACTTTGACAACTTCTTCTTC GCCATGCTGACAGTCTTCCAGTGTGTCACCATGGAAGGCTGGACCGATGTGCTCTACTGGATGCAAGAT GCCATGGGGTATGAACTGCCCTGGGTGTACTTTGTGAGCCTTGTCATCTTTGGGTCCTTCTTCGTCCTC AACCTTGTGCTTGGCGTCCTGAGTGGGGAGTTCTCCAAGGAGAGAGAGAAAGCGAAAGCTCGCGGGGAC TTCCAGAAGCAGCGGGAGAAGCAGCAGATGGAGGAAGACCTGCGGGGCTACCTGGACTGGATCACTCAA GCCGAAGAGCTGGACATGGAGGACCCCTCCGCCGATGACAACCTTGGTTCTATGGCTGAAGAGGGCCGG GCGGGCCATCGGCCACAGCTGGCCGAGCTGACCAATAGGAGGCGTGGACGTCTGCGCTGGTTCAGTCAT TCTACTCGCTCCACACACTCCACCAGCAGCCATGCCAGCCTCCCAGCCAGTGACACCGGTTCCATGACA GAGACCCAAGGCGATGAGGATGAGGAGGAGGGGGCTCTGGCCAGCTGTACACGCTGCCTAAACAAGATC ATGAAAACCAGAGTCTGCCGCCGCCTCCGCCGAGCCAACCGGGTCCTTCGGGCACGCTGCCGTCGGGCA GTGAAGTCCAATGCCTGCTACTGGGCTGTGCTGTTGCTCGTCTTCCTCAACACGTTGACCATCGCCTCT GAGCACCACGGGCAGCCTGTGTGGCTCACCCAGATCCAGGAGTATGCCAACAAAGTGTTGCTCTGTCTG TTCACGGTGGAGATGCTTCTCAAATTGTACGGTCTGGGCCCCTCTGCCTATGTGTCTTCCTTCTTCAAC CGCTTTGACTGCTTTGTGGTCTGTGGGGGCATCCTAGAGACCACCTTGGTGGAGGTGGGTGCCATGCAG CCCTTGGGCATCTCAGTGCTCCGATGTGTGCGCCTCCTCAGGATCTTTAAGGTCACCAGACACTGGGCT TCTCTGAGCAATCTGGTGGCATCCCTGCTCAATTCAATGAAATCCATCGCATCCTTGCTGCTTCTCCTC TTCCTCTTCATCATTATCTTCTCCCTGCTTGGCATGCAGCTGTTTGGGGGCAAGTTCAACTTTGACCAG ACCCACACCAAGCGAAGCACCTTTGACACGTTCCCCCAGGCCCTCCTCACTGTCTTTCAGATCCTGACA GGTGAGGACTGGAACGTGGTCATGTATGATGGTATCATGGCATATGGTGGCCCCTTCTTCCCAGGAATG TTGGTGTGCATCTATTTCATCATTCTCTTCATCTGTGGCAACTACATCCTGTTGAACGTGTTTCTTGCC ATTGCTGTGGACAACCTGGCCAGTGGAGATGCAGGCACTGCCAAGGACAAGGGCGGGGAGAAGAGCAAT GAGAAGGATCTCCCACAGGAGAATGAAGGCCTGGTGCCTGGTGTGGAGAAAGAGGAAGAGGAGGGTGCA AGGAGGGAAGGAGCAGACATGGAGGAGGAGGAGGAGGAGGAAGAAGAGGAAGAAGAGGAAGAAGAGGAA GAGGGTGCAGGGGGTGTGGAACTCCTGCAGGAAGTTGTACCCAAGGAGAAGGTGGTACCCATCCCTGAG GGCAGCGCCTTCTTCTGCCTCAGCCAAACCAACCCGCTGAGGAAGGGCTGCCACACCCTCATCCACCAT CATGTCTTCACCAATCTTATCCTGGTGTTCATCATCCTCAGCAGTGTGTCCCTGGCCGCTGAGGACCCC ATCCGAGCCCACTCCTTCCGCAACCATATTCTGGGTTACTTCGATTATGCCTTCACCTCCATTTTCACT GTGGAGATTCTACTAAAGATGACAGTGTTTGGGGCCTTCCTGCACCGCGGCTCCTTCTGCCGTAGCTGG TTTAATATGTTGGATCTGCTGGTGGTCAGTGTGTCCCTCATCTCCTTTGGCATCCACTCCAGCGCCATC TCGGTGGTGAAGATTCTGCGAGTACTCCGAGTACTGCGGCCCCTCCGAGCCATCAACAGGGCCAAGGGA CTCAAGCATGTGGTGCAGTGTGTATTTGTGGCCATCCGGACCATCGGAAACATCATGATTGTCACCACA CTTCTGCAATTTATGTTCGCCTGCATCGGGGTGCAGCTCTTCAAGGGGAAATTCTACACCTGCACGGAC GAGGCCAAACACACCCCTCAAGAATGCAAGGGCTCCTTCCTGGTATACCCAGATGGAGACGTGTCACGG CCCCTGGTCCGGGAGCGGCTCTGGGTCAACAGTGATTTCAACTTTGACAATGTCCTTTCAGCCATGATG GCCCTGTTCACTGTCTCCACCTTTGAAGGCTGGCCTGCACTGCTATACAAGGCCATCGATGCATATGCA GAGGACCACGGCCCCATCTATAATTACCGTGTGGAGATCTCAGTGTTCTTCATTGTCTACATCATCATC ATTGCGTTCTTCATGATGAACATCTTCGTGGGCTTCGTCATCATCACTTTCCGTGCCCAGGGCGAGCAG GAGTACCAAAACTGTGAGCTGGACAAGAACCAGCGTCAATGTGTGGAATATGCCCTCAAGGCCCAGCCA CTCCGCCGTTACATCCCCAAGAACCCGCATCAGTATCGTGTGTGGGCCACTGTGAACTCTGCTGCCTTT GAGTACCTGATGTTCCTGCTCATCCTGCTCAACACAGTTGCCCTAGCCATGCAGCACTATGAGCAGACT GCTCCCTTCAACTATGCCATGGACATCCTCAACATGGTCTTCACTGGCCTCTTCACTATTGAGATGGTG CTCAAAATCATCGCCTTCAAGCCCAAGCATTACTTCACTGATGCCTGGAACACGTTTGACGCTCTTATT GTGGTGGGCAGCATAGTGGATATTGCCGTCACTGAAGTCAATAATGGTGGCCACCTTGGCGAGAGCTCT GAGGACAGCTCCCGCATTTCCATTACCTTCTTTCGCCTCTTCCGAGTTATGCGGCTGGTCAAGCTTCTC AGTAAGGGTGAAGGGATCCGCACATTGCTCTGGACATTCATCAAGTCCTTCCAGGCCTTGCCCTATGTG GCTCTTCTCATCGCAATGATATTCTTCATCTATGCCGTCATTGGCATGCAGATGTTCGGCAAGGTGGCT CTTCAGGATGGCACACAGATAAACCGAAACAACAACTTCCAGACCTTTCCACAGGCTGTGCTGCTTCTG TTCAGGTGTGCCACTGGTGAGGCATGGCAGGAGATAATGCTTGCCAGCCTTCCCGGAAATCGGTGTGAT CCTGAGTCTGACTTCGGCCCTGGTGAAGAGTTTACCTGTGGTAGCAATTTTGCCATCGCCTATTTCATC AGCTTCTTCATGCTCTGTGCCTTCCTGATCATAAATCTCTTTGTGGCTGTGATCATGGACAACTTTGAT TATCTCACCAGAGATTGGTCCATCCTGGGCCCCCATCACCTTGATGAATTCAAGAGGATCTGGTCTGAA TATGACCCTGGGGCCAAGGGCCGCATCAAACACTTGGATGTGGTTGCCCTGCTGAGACGTATCCAGCCC CCTCTGGGATTTGGGAAGCTGTGCCCACACCGAGTGGCCTGCAAGAGACTTGTGGCAATGAACATGCCC CTCAACTCAGATGGGACGGTGACATTCAACGCCACACTCTTTGCCCTGGTCCGGACATCCCTGAAGATC AAAACAGAAGGGAACCTGGAGCAAGCCAACCAGGAGCTGCGGATTGTCATCAAAAAGATCTGGAAGCGG ATGAAACAGAAGCTGCTAGATGAGGTCATCCCCCCACCAGACGAGGAGGAGGTCACCGTGGGCAAATTC TACGCCACATTTCTGATCCAGGACTATTTCCGCAAATTCCGGCGGAGGAAAGAAAAAGGGCTACTAGGC AACGACGCCGCCCCTAGCACCTCTTCCGCCCTTCAGGCTGGTCTGCGGAGCCTGCAGGACTTGGGTCCT GAGATGCGGCAGGCCCTCACCTGTGACACAGAGGAGGAGGAAGAAGAGGGGCAGGAGGGAGTGGAGGAG GAAGATGAAAAGGACTTGGAAACTAACAAAGCCACGATGGTCTCCCAGCCCTCAGCTCGCCGGGGCTCC GGGATTTCTGTGTCTCTGCCTGTCGGGGACAGACTTCCAGATTCACTCTCCTTTGGGCCCAGTGATGAT GACAGGGGGACTCCCACCTCCAGTCAGCCCAGTGTGCCCCAGGCTGGATCCAACACCCACAGGAGAGGC TCTGGGGCTCTCATTTTCACCATCCCAGAAGAAGGAAATTCTCAGCCCAAGGGAACCAAAGGGCAAAAC AAGCAAGATGAGGATGAGGAAGTCCCTGATCGGCTTTCCTACCTAGATGAGCAGGCAGGGACTCCCCCG TGCTCAGTCCTTTTGCCACCTCACAGAGCTCAGAGATACATGGATGGGCACCTGGTACCACGCCGCCGT CTGCTGCCCCCCACACCTGCAGGTCGGAAGCCCTCCTTCACCATCCAGTGTCTGCAGCGCCAGGGCAGT TGTGAGGATTTACCCATCCCAGGCACCTATCATCGTGGGCGAAATTCAGGGCCCAATAGGGCTCAGGGT TCCTGGGCAACACCACCTCAGCGGGGTCGGCTCCTGTATGCCCCGCTGTTGTTGGTGGAAGAGGGCGCA GCGGGGGAGGGGTACCTCGGCAGATCCAGTGGCCCACTGCGCACCTTCACCTGTCTGCACGTGCCTGGA ACCCACTCGGACCCCAGCCATGGGAAGAGGGGCAGTGCCGACAGCTTGGTGGAGGCTGTGCTTATCTCA GAGGGTCTGGGCCTCTTTGCTCGAGACCCACGTTTCGTGGCCCTGGCCAAGCAGGAGATTGCAGATGCG TGTCGCCTGACGCTGGATGAGATGGACAATGCTGCCAGTGACCTGCTGGCACAGGGAACCAGCTCTCTC TATAGCGACGAGGAGTCCATCCTCTCCCGCTTCGATGAGGAGGACTTGGGAGACGAGATGGCCTGCGTC CACGCCCTCTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001256790
Insert Size	5739 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001256790.2
RefSeq Size	5875 bp
RefSeq ORF	5739 bp
Locus ID	778
UniProt ID	O60840
Protein Families	Druggable Genome, Ion Channels: Calcium, Transmembrane
Protein Pathways	Alzheimer's disease, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Calcium signaling pathway, Cardiac muscle contraction, Dilated cardiomyopathy, GnRH signaling pathway, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Vascular smooth muscle contraction
MW	214 kDa
Gene Summary	This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2013] Transcript Variant: This variant (3) uses two alternate splice sites in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

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