KAT6B (NM_001256468) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	GTPTS; MORF; MOZ2; MYST4; qkf; querkopf; ZC2HC6B
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332390 representing NM_001256468. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGTAAAACTTGCAAACCCACTTTATACAGAGTGGATTCTTGAAGCTATACAGAAAATAAAAAAGCAA AAGCAAAGGCCCTCTGAAGAGAGAATCTGCCATGCGGTCAGTACTTCCCATGGGTTGGATAAGAAGACA GTCTCTGAACAGCTGGAACTCAGTGTTCAGGATGGCTCAGTTCTCAAAGTCACCAACAAAGGCCTTGCC TCCTATAAGGACCCAGACAACCCTGGGCGCTTTTCATCAGTTAAACCAGGCACTTTTCCTAAGTCAGCC AAGGGGTCTAGAGGATCATGTAATGATCTCCGCAATGTGGATTGGAATAAACTTTTAAGGAGAGCAATT GAAGGACTTGAGGAGCCGAATGGCTCCTCCCTGAAGAACATAGAGAAGTATCTCAGAAGTCAAAGTGAT CTCACAAGCACCACCAACAACCCAGCCTTTCAGCAGCGGCTGCGACTGGGGGCCAAACGCGCTGTGAAT AATGGGAGGTTACTGAAAGACGGACCGCAGTACAGGGTCAATTATGGGAGCTTAGATGGCAAAGGGGCA CCTCAGTATCCCAGTGCATTCCCATCCTCGCTCCCACCTGTCAGCCTTCTACCCCATGAGAAAGACCAG CCCCGTGCTGATCCCATTCCAATATGTAGCTTCTGTTTGGGGACTAAAGAATCAAATCGTGAAAAGAAA CCAGAAGAACTCCTCTCTTGTGCAGATTGTGGCAGTAGTGGACACCCATCCTGTTTGAAATTTTGTCCT GAATTAACAACAAATGTAAAGGCCTTAAGGTGGCAGTGCATCGAATGCAAGACATGCAGTGCCTGTAGA GTCCAAGGCAGAAATGCTGATAATATGCTTTTTTGTGATTCCTGTGATAGAGGATTTCATATGGAATGC TGTGACCCACCACTTTCCAGAATGCCAAAAGGGATGTGGATTTGCCAAGTCTGCAGACCAAAGAAAAAG GGAAGAAAACTACTTCATGAGAAAGCTGCACAAATAAAACGACGATATGCAAAACCCATTGGACGACCG AAAAATAAATTAAAGCAACGATTGTTGTCTGTAACCAGTGATGAAGGATCCATGAATGCATTCACAGGA AGGGGGTCACCTGGTAGGGGTCAAAAGACTAAAGTCTGTACCACACCTTCATCTGGTCATGCTGCATCT GGGAAGGACTCAAGCAGCAGATTGGCTGTTACAGACCCCACTCGGCCTGGTGCCACCACCAAAATCACC ACCACCTCCACCTACATTTCTGCCTCTACACTTAAAGTTAACAAGAAAACCAAAGGGCTCATTGATGGC CTTACTAAGTTTTTTACACCATCACCTGATGGTCGCAGATCACGAGGTGAAATTATAGACTTTTCAAAG CACTATCGTCCAAGGAAAAAGGTCTCTCAGAAACAGTCATGCACTTCTCATGTGTTGGCTACAGATACT GAAATAAAAATAAACATCAAACAAGAAAGTGCAGATGTAAATGTGATTGGAAACAAGGATGTCGTTACT GAAGAGGATTTGGATGTTTTTAAGCAGGCCCAGGAACTTTCTTGGGAGAAAATAGAGTGTGAGAGTGGG GTGGAAGACTGTGGCCGGTACCCTTCTGTGATTGAATTTGGTAAATATGAAATCCAAACCTGGTACTCC TCGCCTTACCCACAGGAATATGCAAGATTACCAAAGCTTTACCTGTGTGAATTCTGTCTTAAATATATG AAAAGTAAAAATATTTTGCTAAGACACTCCAAGAAGTGTGGATGGTTTCATCCTCCAGCAAATGAAATT TACCGAAGGAAAGACCTTTCAGTATTTGAGGTTGATGGGAATATGAGCAAAATTTATTGCCAAAACCTT TGCTTGTTAGCCAAGCTCTTCCTGGACCACAAAACGTTGTATTATGATGTCGAGCCATTCCTTTTTTAT GTCCTTACAAAAAATGATGAAAAGGGCTGTCATCTGGTTGGATACTTCTCTAAGGAAAAGCTTTGCCAG CAGAAGTATAATGTCTCCTGCATAATGATCATGCCCCAGCACCAAAGGCAAGGATTTGGACGGTTTCTC ATTGATTTCAGCTATTTGCTTTCTAGAAGAGAAGGCCAAGCAGGGTCTCCTGAAAAGCCTCTCTCCGAT CTGGGCCGTCTCTCCTACCTGGCATATTGGAAGAGCGTCATCTTGGAGTATCTCTACCACCACCATGAG AGGCACATCAGCATCAAGGCAATTAGCAGAGCGACGGGCATGTGCCCACATGACATTGCCACCACTCTG CAGCACCTCCACATGATCGACAAGAGAGATGGCAGATTTGTCATCATTAGACGGGAAAAGTTGATATTG AGCCACATGGAAAAGCTGAAAACCTGTTCCAGAGCCAATGAACTTGATCCAGACAGTCTGAGGTGGACC CCAATTTTAATTTCTAATGCTGCAGTGTCTGAAGAAGAGCGAGAAGCTGAGAAAGAGGCTGAGCGGCTA ATGGAACAAGCTAGCTGCTGGGAGAAGGAGGAACAAGAAATCCTGTCAACTAGAGCTAACAGTAGGCAA TCACCTGCAAAAGTACAATCGAAAAATAAATATTTGCATTCCCCGGAGAGCCGGCCAGTCACAGGGGAG CGAGGGCAGCTGCTGGAGCTGTCTAAAGAGAGCAGTGAAGAAGAAGAGGAGGAGGAGGACGAGGAGGAG GAAGAAGAGGAGGAAGAAGAGGAAGAGGATGAAGAGGAGGAAGAAGAGGAAGAAGAAGAAGAAGAAGAA GAAAATATTCAAAGCTCTCCCCCAAGATTGACGAAACCACAGTCAGTTGCCATAAAGAGAAAGAGGCCT TTTGTACTAAAGAAGAAAAGGGGTCGTAAACGCAGGAGGATCAACAGCAGTGTAACAACAGAGACCATT TCAGAGACGACAGAAGTACTGAATGAGCCCTTTGACAACTCAGATGAAGAGAGGCCAATGCCACAGCTG GAGCCTACCTGTGAGATTGAAGTGGAGGAAGATGGCAGGAAGCCAGTCCTGAGAAAAGCATTCCAGCAT CAGCCTGGGAAGAAAAGACAAACAGAGGAAGAGGAAGGAAAAGACAATCATTGCTTCAAGAATGCTGAC CCTTGTAGAAACAATATGAATGATGATTCAAGTAACTTGAAAGAAGGCAGTAAAGACAATCCCGAACCT CTAAAGTGCAAACAAGTGTGGCCAAAAGGAACAAAGCGCGGTCTATCTAAGTGGAGGCAAAACAAAGAG AGGAAGACCGGATTTAAACTGAATTTGTACACCCCGCCAGAAACACCCATGGAGCCTGACGAGCAGGTA ACAGTGGAAGAACAGAAGGAGACTTCAGAAGGAAAAACCAGCCCCAGTCCCATCAGGATTGAGGAGGAG GTCAAGGAAACTGGGGAAGCCCTGTTGCCTCAAGAGGAAAACAGAAGGGAAGAAACATGTGCCCCTGTA AGTCCAAACACATCACCAGGTGAAAAACCAGAAGATGATCTCATCAAACCTGAGGAAGAGGAAGAGGAG GAGGAGGAGGAAGAGGAAGAAGAGGAAGAAGAGGAAGGGGAAGAAGAAGAAGGAGGAGGAAATGTAGAA AAAGATCCAGATGGTGCTAAAAGCCAAGAAAAAGAGGAACCAGAAATCTCCACGGAAAAAGAAGACTCT GCACGTTTGGATGATCACGAAGAGGAGGAGGAAGAGGATGAAGAGCCATCCCACAACGAGGACCATGAT GCCGATGACGAGGATGACAGCCACATGGAGTCTGCCGAAGTGGAGAAGGAAGAGCTGCCCAGAGAAAGC TTCAAAGAAGTACTGGAAAACCAGGAGACTTTTTTAGACCTTAATGTGCAGCCTGGTCACTCGAACCCA GAGGTCTTAATGGACTGTGGCGTCGACCTGACAGCTTCTTGTAACAGTGAGCCCAAGGAGCTTGCTGGG GACCCTGAAGCTGTACCCGAATCTGACGAGGAGCCACCCCCAGGAGAACAGGCACAGAAGCAGGACCAA AAGAACAGCAAGGAAGTCGATACAGAGTTCAAAGAGGGAAACCCAGCAACCATGGAAATCGACTCTGAG ACTGTCCAGGCCGTTCAGTCTTTGACCCAGGAGAGCAGCGAACAGGACGACACCTTTCAGGATTGTGCC GAGACTCAAGAGGCCTGTAGAAGCCTACAGAACTACACCCGTGCAGACCAAAGTCCACAGATTGCCACC ACGCTCGACGATTGCCAACAGTCGGACCACAGTAGCCCAGTTTCATCCGTCCACTCCCATCCTGGCCAG TCCGTACGTTCTGTCAACAGCCCAAGTGTCCCTGCTCTGGAAAACAGCTACGCCCAAATCAGCCCAGAT CAAAGTGCCATCTCAGTGCCATCTCTGCAGAACATGGAAACCAGTCCCATGATGGATGTCCCATCAGTT TCAGATCATTCACAGCAAGTCGTAGACAGTGGATTTAGTGACCTGGGCAGTATCGAGAGCACAACTGAG AACTACGAAAACCCAAGCAGCTACGATTCTACTATGGGAGGCAGCATCTGTGGAAACGGCTCTTCACAG AACAGCTGCTCCTATAGCAACCTCACCTCCAGCAGTCTGACACAGAGCAGCTGTGCTGTCACCCAGCAG ATGTCCAACATCAGCGGGAGCTGCAGCATGCTGCAGCAAACCAGCATCAGCTCCCCTCCGACCTGCAGC GTCAAGTCTCCTCAAGGCTGTGTGGTGGAGAGGCCTCCGAGCAGCAGCCAGCAGCTGGCTCAGTGCAGC ATGGCTGCTAACTTCACCCCACCCATGCAGCTGGCTGAAATCCCCGAGACGAGCAACGCCAACATTGGC TTATACGAGCGAATGGGTCAGAGTGATTTTGGGGCTGGGCATTACCCGCAGCCGTCAGCCACCTTCAGC CTTGCCAAACTGCAGCAGTTAACTAATACACTTATTGATCATTCATTGCCTTACAGCCATTCCGCTGCT GTGACTTCCTATGCAAACAGTGCCTCTTTGTCCACACCATTAAGTAACACAGGGCTTGTTCAACTTTCT CAGTCTCCACACTCCGTCCCTGGGGGACCCCAAGCACAAGCTACCATGACCCCACCCCCCAACCTGACT CCTCCTCCAATGAATCTGCCGCCGCCTCTTTTGCAACGGAACATGGCTGCATCAAATATTGGCATCTCT CACAGCCAAAGACTGCAAACCCAGATTGCCAGCAAGGGCCACATCTCCATGAGAACCAAGTCAGCGTCT CTGTCACCAGCCGCTGCCACCCATCAGTCACAAATCTATGGGCGCTCCCAGACTGTAGCCATGCAGGGT CCTGCACGGACTTTAACGATGCAAAGAGGCATGAACATGAGTGTGAACCTGATGCCAGCGCCAGCCTAC AATGTCAACTCTGTGAACATGAACATGAACACTCTCAACGCCATGAATGGGTACAGCATGTCCCAGCCA ATGATGAACAGTGGCTACCACAGCAATCATGGCTATATGAATCAAACGCCCCAATACCCTATGCAGATG CAGATGGGCATGATGGGCACCCAGCCATATGCCCAGCAGCCAATGCAGACCCCACCCCACGGTAACATG ATGTACACGGCCCCCGGACATCACGGCTACATGAACACAGGCATGTCCAAACAGTCTCTCAATGGCTCC TACATGAGAAGGTAG
Restriction Sites	SgfI-MluI
ACCN	NM_001256468
Insert Size	5673 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001256468.1
RefSeq Size	7960 bp
RefSeq ORF	5673 bp
Locus ID	23522
UniProt ID	Q8WYB5
Protein Families	Druggable Genome
MW	211.5 kDa
Gene Summary	The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).

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