CLACP (COL25A1) (NM_001256074) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	AMY; CFEOM5; CLAC; CLAC-P; CLACP
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332294 representing NM_001256074. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGCTGCTGAAGAAGCACGCAGGGAAAGGAGGGGGCCGGGAGCCCAGATCCGAGGACCCGACCCCTGCC GAACAGCATTGTGCCCGGACCATGCCCCCGTGTGCCGTCCTGGCGGCCCTCCTGTCAGTGGTGGCCGTG GTGTCTTGCCTGTACCTGGGTGTGAAAACCAACGACCTCCAGGCGAGGATCGCCGCTCTCGAATCCGCC AAAGGGGCCCCTTCCATTCATCTGCTGCCTGATACCCTGGATCACCTCAAGACTATGGTGCAAGAGAAA GTGGAGCGACTTCTGGCTCAGAAATCCTATGAACATATGGCTAAAATAAGAATCGCAAGAGAAGCACCT TCAGAATGTAACTGCCCAGCAGGCCCTCCAGGGAAACGAGGTAAGAGAGGCCGAAGAGGAGAATCTGGT CCTCCTGGACAGCCTGGTCCTCAGGGCCCTCCTGGTCCAAAAGGCGATAAGGGAGAACAAGGTGATCAG GGACCTAGGGGCCTGCCAGGCTTCCCCACAGTTGCTGCCCTGCACAGTAATCAGATCCTCACCGTCAAG GGTGACCAAGGACAGGCAGGGCCTCCAGGACCCCCTGGCCCTCCAGGCCCAAGAGGGCCACCTGGGGAC ACAGGGAAAGATGGCCCCCGTGGAATGCCAGGAGTACCCGGTGAACCAGGAAAGCCAGGAGAACAAGGC TTGATGGGTCCTCTAGGGCCTCCGGGACAAAAGGGTTCTATTGGAGCACCTGGAATTCCAGGGATGAAT GGGCAAAAGGGTGAGCCCGGGTTGCCTGGAGCAGTAGGACAGAATGGAATACCAGGACCTAAGGGAGAA CCTGGAGAACAAGGTGAAAAGGGAGACGCTGGAGAGAACGGCCCCAAGGGTGACACAGGCGAAAAGGGT GACCCTGGATCATCTGCTGCAGGAATTAAGGGAGAACCTGGGGAATCTGGTCGTCCAGGGCAAAAGGGT GAACCAGGGCTTCCTGGGCTTCCTGGACTTCCGGGGATAAAGGGAGAACCAGGTTTCATTGGTCCTCAA GGAGAACCAGGCTTACCAGGTTTACCAGGAACAAAAGGTGAACGGGGGGAAGCAGGGCCTCCTGGAAGA GGTGAGCGAGGGGAACCTGGAGCCCCCGGACCAAAGGGGGATCGTGGAGAAAAAGGGGACTCTGGAGCT CAGGGACCAAGGGGTCCACCTGGTCAAAAAGGGGATCAAGGAGCCACTGAGATCATAGACTACAACGGC AACCTCCACGAAGCCTTACAGGGTCCCCCTGGACCTCCTGGACCTCAAGGACTACAAGGGCCAAAGGGA GAGCAGGGATCTCCAGGAATCCCAGGAATGGATGGAGAGCAGGGACTCAAAGGCTCAAAGGGAGACATG GGGGACCCAGGTATGACAGGTGAAAAAGGAGGAATTGGACTTCCTGGATTACCGGGAGCCAATGGAATG AAAGGAGAAAAAGGAGATTCTGGAATGCCGGGTCCACAGGGTCCTTCTATCATAGGCCCACCAGGCCCA CCAGGTCCCCATGGCCCACCTGGCCCCATGGGACCTCATGGACTTCCTGGACCAAAGGGTGAACCAGGG TTAAATGGTGTTAAAGGATTGAAGGGTGAACCAGGTCAAAAGGGTGACAGAGGACCCCTTGGTCTTCCA GGAGCATCTGGCTTAGACGGAAAGCCAGGATCCCGGGGTACAGATGGTCCTATGGGACCCCATGGCCCT GCAGGTCCCAAAGGAGAAAGAGGTGAAAAAGGAGCTATGGGAGAGCCTGGACCAAGAGGGCCCTATGGG CTGCCTGGCTTCCCTGGTCCACGGGGTGAGAAGGGTGATCTAGGAGAAAAGGGAGAAAAGGTGACCTCT CCATCCCAGCATGTACCTTGTTTGATTCTTCTCCTGCTGTCTGCTTTGCTGTTCAGCTTGTGTGATTCC ATTTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001256074
Insert Size	1938 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001256074.1
RefSeq Size	2507 bp
RefSeq ORF	1938 bp
Locus ID	84570
Protein Families	Transmembrane
MW	63.4 kDa
Gene Summary	This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, and also differs in the 5' and 3' UTRs, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

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