PACSIN1 (NM_001199583) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	SDPI
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC331329 representing NM_001199583. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGTCCAGCTCCTACGATGAGGCCTCACTGGCGCCAGAGGAGACCACCGACAGCTTCTGGGAGGTGGGG AACTACAAGCGGACCGTGAAGCGCATCGATGACGGCCACCGTCTATGCAACGACCTGATGAACTGCGTG CAGGAGCGCGCCAAGATCGAGAAGGCGTACGGGCAGCAGCTCACCGACTGGGCCAAGCGTTGGCGCCAG CTCATCGAGAAAGGCCCACAGTATGGCAGCCTGGAGCGGGCCTGGGGTGCCATAATGACAGAGGCAGAC AAGGTGAGCGAGCTGCACCAGGAGGTGAAGAACAATCTGCTGAATGAGGACCTGGAGAAGGTGAAGAAC TGGCAGAAGGACGCCTATCACAAGCAGATCATGGGTGGCTTCAAGGAGACGAAGGAGGCTGAAGATGGC TTCCGCAAGGCCCAGAAGCCTTGGGCCAAGAAGATGAAGGAGCTGGAGGCAGCCAAGAAGGCCTACCAT TTGGCTTGCAAAGAGGAAAAGCTGGCCATGACACGGGAGATGAACAGCAAGACGGAGCAATCGGTCACA CCTGAGCAGCAAAAGAAGCTGCAGGACAAAGTGGACAAGTGCAAGCAGGATGTGCAGAAGACACAGGAG AAGTATGAGAAAGTGCTGGAAGATGTGGGCAAGACCACACCCCAGTACATGGAGAACATGGAGCAGGTG TTTGAGCAATGCCAGCAATTTGAGGAAAAGCGGCTGGTCTTCCTCAAGGAGGTGCTGCTGGACATCAAA CGGCACCTCAACCTGGCTGAGAACAGCAGCTACATCCATGTGTACCGTGAGCTGGAGCAGGCCATCCGG GGGGCTGATGCCCAGGAAGACCTCAGATGGTTCCGCAGCACCAGTGGCCCCGGCATGCCCATGAACTGG CCCCAGTTTGAGGAGTGGAACCCAGACCTTCCTCACACCACCACCAAGAAGGAGAAACAGCCTAAGAAG GCAGAGGGAGTGGCGCTGACCAATGCCACTGGGGCGGTAGAGTCCACATCCCAGGCTGGGGACCGCGGC AGTGTTAGCAGCTACGACAGAGGCCAGCCCTACGCCACCGAGTGGTCAGACGACGAGAGTGGGAACCCC TTTGGGGGCAGTGAGACCAACGGGGGCGCCAACCCCTTTGAGGACGACTCCAAGGGAGTGCGCGTGCGG GCACTCTACGACTATGACGGCCAGGAGCAGGACGAGCTCAGCTTTAAGGCCGGAGACGAACTCACCAAG CTGGGCGAGGAGGATGAGCAGGGCTGGTGCCGTGGGCGGCTGGACAGCGGGCAGCTGGGCCTCTACCCT GCCAACTACGTGGAGGCTATCTAG
Restriction Sites	SgfI-MluI
ACCN	NM_001199583
Insert Size	1335 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001199583.2
RefSeq Size	4332 bp
RefSeq ORF	1335 bp
Locus ID	29993
UniProt ID	Q9BY11
Protein Families	Druggable Genome
MW	51 kDa
Gene Summary	Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) has an alternate 5' UTR exon and encodes the same protein as variant 1.

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