COPS4 (NM_001258006) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CSN4; SGN4
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC330628 representing NM_001258006. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCT GGCAAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAA GCTTTTGTGGAAGCAATGGTAAATGAGAATGTCAGTCTCGTGATCTCGCGGCAGTTGCTGACTGATTTT TGCACACATCTTCCTAACTTGCCTGATAGCACAGCCAAAGAAATCTATCACTTCACCTTGGAAAAGATC CAGCCTAGAGTCATTTCATTTGAGGAGCAGGTTGCTTCCATAAGACAGCATCTTGCATCTATATATGAG AAAGAAGAAGATTGGAGAAATGCAGCCCAAGTGTTGGTGGGAATTCCTTTGGAAACAGGACAAAAACAG TACAATGTAGATTATAAACTGGAGACTTACTTGAAGATTGCTAGGCTATATCTGGAGGATGATGATCCA GTCCAGGCAGAGGCTTACATAAATCGAGCATCGTTGCTTCAGAATGAATCAACCAATGAACAATTACAG ATACATTATAAGGTATGCTATGCACGTGTTCTTGATTATAGAAGAAAATTCATTGAAGCTGCACAAAGG TACAATGAGCTCTCTTACAAGACAATAGTCCACGAAAGTGAAAGACTAGAGGCCTTAAAACATGCTTTG CACTGTACGATCTTAGCATCAGCAGGGCAGCAGCGTTCTCGGATGCTAGCTACTCTTTTTAAGGATGAA AGGTGCCAGCAACTTGCTGCCTATGGGATCCTAGAGAAAATGTATCTAGATAGGATCATCAGAGGAAAT CAACTTCAAGAATTTGCTGCCATGCTGATGCCTCACCAAAAAGCAACTACAGCTGATGGTTCCAGCATC TTGGACAGAGCTGTTATTGAACACAATTTGTTGTCTGCAAGCAAATTATATAATAATATTACCTTCGAA GAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGCACGAGAAGCCCTGCCAACGTGGGATAAGCAGA TCCAATCACTTTGTTTCCAAGTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001258006
Insert Size	1059 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001258006.1
RefSeq Size	1680 bp
RefSeq ORF	1059 bp
Locus ID	51138
UniProt ID	Q9BT78
MW	40.2 kDa
Gene Summary	This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

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