Cellular Apoptosis Susceptibility (CSE1L) (NM_001256135) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CAS; CSE1; XPO2
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC330372 representing NM_001256135. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGAACTCAGCGATGCAAATCTGCAAACACTAACAGAATATTTAAAGAAAACACTTGATCCTGATCCT GCCATCCGACGTCCAGCTGAGAAATTTCTTGAATCTGTTGAAGGAAATCAGAATTATCCACTGTTGCTT TTGACATTACTGGAGAAGTCCCAGGATAATGTTATCAAAGTATGTGCTTCAGTAACATTCAAAAACTAT ATTAAAAGGAACTGGAGAATTGTTGAAGATGAACCAAACAAAATTTGTGAAGCCGATCGAGTGGCCATT AAAGCCAACATAGTGCACTTGATGCTTAGCAGCCCAGAGCAAATTCAGAAGCAGTTAAGTGATGCAATT AGCATTATTGGCAGAGAAGATTTTCCACAGAAATGGCCTGACTTGCTGACAGAAATGGTGAATCGCTTT CAGAGTGGAGATTTCCATGTTATTAATGGAGTCCTCCGTACAGCACATTCATTATTTAAAAGATACCGT CATGAATTTAAGTCAAACGAGTTATGGACTGAAATTAAGCTTGTTCTGGATGCCTTTGCTTTGCCTTTG ACTAATCTTTTTAAGGCCACTATTGAACTCTGCAGTACCCATGCAAATGATGCCTCTGCCCTGAGGATT CTGTTTTCTTCCCTGATCCTGATCTCAAAATTGTTCTATAGTTTAAACTTTCAGGATCTCCCTGAATTT TTTGAAGATAATATGGAAACTTGGATGAATAATTTTCATACTCTCTTAACATTGGATAATAAGCTTTTA CAAACTGATTTGGTAAGTAATGCAATTCAATTTCTGGCTTCAGTTTGTGAGAGACCTCATTATAAGAAT CTATTTGAGGACCAGAACACGCTGACAAGTATCTGTGAAAAGGTTATTGTGCCTAACATGGAATTTAGA GCTGCTGATGAAGAAGCATTTGAAGATAATTCTGAGGAGTACATAAGGAGAGATTTGGAAGGATCTGAT ATTGATACTAGACGCAGGGCTGCTTGTGATCTGGTACGAGGATTATGCAAGTTTTTTGAGGGACCTGTG ACAGGAATCTTCTCTGGTTATGTTAATTCCATGCTGCAGGAATACGCAAAAAATCCATCTGTCAACTGG AAACACAAAGATGCAGCCATCTACCTAGTGACATCTTTGGCATCAAAAGCCCAAACACAGAAGCATGGA ATTACACAAGCAAATGAACTTGTAAACCTAACTGAGTTCTTTGTGAATCACATCCTCCCTGATTTAAAA TCAGCTAATGTGAATGAATTTCCTGTCCTTAAAGCTGACGGTATCAAATATATTATGATTTTTAGAAAT CAAGTGCCAAAAGAACATCTTTTAGTCTCGATTCCTCTCTTGATTAATCATCTTCAAGCTGAAAGTATT GTTGTTCATACTTACGCAGCTCATGCTCTTGAACGGCTCTTTACTATGCGAGGGCCTAACAATGCCACT CTCTTTACAGCTGCAGAAATCGCACCGTTTGTTGAGATTCTGCTAACAAACCTTTTCAAAGCTCTCACA CTTCCTGGCTCTTCAGAAAATGAATATATTATGAAAGCTATCATGAGAAGTTTTTCTCTCCTACAAGAA GCCATAATCCCCTACATCCCTACTCTCATCACTCAGCTTACACAGAAGCTATTAGCTGTTAGTAAGAAC CCAAGCAAACCTCACTTTAATCACTACATGTTTGAAGCAATATGTTTATCCATAAGAATAACTTGCAAA GCTAACCCTGCTGCTGTTGTAAATTTTGAGGAGGCTTTGTTTTTGGTGTTTACTGAAATCTTACAAAAT GATGTGCAAGAATTTATTCCATACGTCTTTCAAGTGATGTCTTTGCTTCTGGAAACACACAAAAATGAC ATCCCGTCTTCCTATATGGCCTTATTTCCTCATCTCCTTCAGCCAGTGCTTTGGGAAAGAACAGGAAAT ATTCCTGCTCTAGTGAGGCTTCTTCAAGCATTCTTAGAACGCGGTTCAAACACAATAGCAAGTGCTGCA GCTGACAAAATTCCTGGGTTACTAGGTGTCTTTCAGAAGCTGATTGCATCCAAAGCAAATGACCACCAA GGTTTTTATCTTCTAAACAGTATAATAGAGCACATGCCTCCTGAATCAGTTGACCAATATAGGAAACAA ATCTTCATTCTGCTATTCCAGAGACTTCAGAATTCCAAAACAACCAAGTTTATCAAGAGTTTTTTAGTC TTTATTAATTTGTATTGCATAAAATATGGGGCACTAGCACTACAAGAAATATTTGATGGTATACAACCA AAAATGTTTGGAATGGTTTTGGAAAAAATTATTATTCCTGAAATTCAGAAGGTATCTGGAAATGTAGAG AAAAAGATCTGTGCGGTTGGCATAACCAAATTACTAACAGAATGTCCCCCAATGATGGACACTGAGTAT ACCAAACTGTGGACTCCATTATTACAGTCTTTGATTGGTCTTTTTGAGTTACCCGAAGATGATACCATT CCTGATGAGGAACATTTTATTGACATAGAAGATACACCAGGATATCAGACTGCCTTCTCACAGTTGGCA TTTGCTGGGAAAAAAGAGCATGATCCTGTAGGTCAAATGGTGAATAACCCCAAAATTCACCTGGCACAG TCACTTCACAAGTTGTCTACCGCCTGTCCAGGAAGGGTTCCATCAATGGTGAGCACCAGCCTGAATGCA GAAGCGCTCCAGTATCTCCAAGGGTACCTTCAGGCAGCCAGTGTGACACTGCTTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001256135
Insert Size	2748 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001256135.1
RefSeq Size	3459 bp
RefSeq ORF	2748 bp
Locus ID	1434
UniProt ID	P55060
Protein Families	Druggable Genome
MW	103.9 kDa
Gene Summary	Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.

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