PPP3CC (NM_001243975) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CALNA3; CNA3; PP2Bgamma
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC330205 representing NM_001243975. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGTCCGGGAGGCGCTTCCACCTCTCCACCACCGACCGCGTCATCAAAGCTGTCCCCTTTCCTCCAACC CAACGGCTTACTTTCAAGGAAGTATTTGAGAATGGGAAACCTAAAGTTGATGTTTTAAAAAACCATTTG GTAAAGGAAGGACGACTGGAAGAGGAAGTAGCCTTAAAGATAATCAATGATGGGGCTGCCATCCTGAGG CAAGAGAAGACTATGATAGAAGTAGATGCTCCAATCACAGTATGTGGTGATATTCATGGACAATTCTTT GACCTAATGAAGTTATTTGAAGTTGGAGGATCACCTAGTAACACACGCTACCTCTTTCTGGGTGACTAT GTGGACAGAGGCTATTTCAGTATAGAGTGTGTGCTGTATTTATGGAGTTTAAAGATTAATCATCCCAAA ACATTGTTTCTGCTTCGGGGAAATCATGAATGCAGGCATCTTACAGACTATTTCACCTTCAAACAGGAA TGTCGAATCAAATATTCGGAACAGGTGTATGATGCCTGTATGGAGACATTTGACTGTCTTCCTCTTGCT GCCCTCTTAAACCAGCAGTTTCTCTGTGTACATGGAGGAATGTCACCTGAAATTACTTCTTTAGATGAC ATTAGGAAATTAGACAGGTTTACGGAACCTCCCGCCTTTGGACCTGTGTGTGACCTGCTTTGGTCTGAT CCCTCAGAGGATTATGGCAATGAGAAGACCTTGGAGCACTATACCCACAACACTGTCCGAGGGTGCTCT TATTTCTACAGTTACCCTGCAGTTTGTGAATTTTTGCAGAACAATAATTTACTATCAATTATCAGAGCC CATGAAGCCCAAGATGCTGGGTATCGAATGTACAGGAAGAGCCAAGCCACAGGCTTTCCATCACTTATT ACAATTTTCTCTGCCCCCAATTACCTAGATGTCTATAACAATAAAGCTGCTGTGTTGAAATATGAAAAC AATGTCATGAATATCAGGCAGTTTAACTGTTCTCCACACCCCTACTGGCTTCCAAACTTTATGGATGTT TTCACATGGTCTTTGCCTTTTGTTGGGGAAAAAGTCACAGAGATGCTGGTAAATGTGCTCAACATATGC TCTGATGACGAACTGATTTCTGATGATGAAGCAGAAGGAAGCACTACAGTTCGTAAGGAGATCATCAGG AATAAGATCAGAGCCATTGGGAAGATGGCACGGGTCTTTTCAATTCTTCGGCAAGAAAGTGAGAGTGTG CTGACTCTCAAGGGCCTGACTCCCACAGGCACACTCCCTCTGGGCGTCCTCTCAGGAGGCAAGCAGACT ATCGAGACAGCCATCAGAGGGTTCTCGCTTCAGCACAAGATCCGGAGTTTTGAAGAAGCGCGAGGTCTG GACCGAATTAATGAGCGAATGCCACCCCGAAAGGATAGCATACACGCTGGTGGGCCAATGAAATCTGTA ACCTCAGCACACTCACATGCTGCGCACAGGAGCGACCAAGGGAAGAAAGCCCATTCATGA
Restriction Sites	SgfI-MluI
ACCN	NM_001243975
Insert Size	1509 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001243975.1
RefSeq Size	2304 bp
RefSeq ORF	1509 bp
Locus ID	5533
UniProt ID	P48454
Protein Families	Druggable Genome, Phosphatase
Protein Pathways	Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Axon guidance, B cell receptor signaling pathway, Calcium signaling pathway, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway
MW	57.1 kDa
Gene Summary	Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) lacks two alternate internal segments compared to isoform 1.

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