United States
Germany
Japan
United Kingdom
China
BCAR1 (NM_001170715) Human Untagged Clone
CAT＃: SC329198
BCAR1 (untagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1) transcript variant 2
CNY 17,100.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CAS; CAS1; CASS1; CRKAS; P130Cas |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_001170715, the custom clone sequence may differ by one or more nucleotides
ATGCACTGCCCTGGTGAGGCTCCTCTGGCTGCCCCCAGGCCCACACCCAAGGATCCCTGC CTCAGAAACGTGCTGGCCAAAGCGCTCTATGACAATGTGGCCGAGTCCCCGGATGAGCTC TCCTTCCGCAAGGGTGACATCATGACGGTGCTGGAGCAGGACACGCAGGGCCTGGACGGC TGGTGGCTCTGCTCGCTGCATGGGCGCCAGGGCATCGTGCCTGGGAACCGCCTCAAGATC TTGGTGGGCATGTATGATAAGAAGCCAGCAGGGCCTGGCCCCGGCCCTCCCGCCACCCCG GCCCAGCCTCAGCCTGGCCTCCATGCCCCAGCGCCTCCGGCCTCCCAGTACACGCCCATG CTCCCCAACACCTACCAGCCCCAGCCAGACAGCGTCTACCTGGTGCCCACTCCCAGCAAG GCTCAGCAAGGCCTCTACCAAGTCCCGGGTCCCAGCCCTCAGTTCCAGTCTCCCCCAGCC AAGCAGACATCCACCTTCTCGAAGCAGACACCCCATCACCCGTTTCCCAGCCCGGCCACA GACCTGTACCAGGTGCCCCCAGGGCCTGGAGGCCCTGCCCAGGATATTTACCAGGTGCCA CCTTCTGCCGGGATGGGGCATGACATCTACCAGGTCCCCCCGTCCATGGACACACGCAGC TGGGAGGGCACGAAGCCCCCGGCAAAGGTGGTGGTGCCCACCCGCGTGGGGCAGGGCTAT GTATACGAGGCCGCCCAGCCGGAGCAGGACGAGTACGACATCCCGCGACACCTGCTGGCC CCGGGGCCACAGGACATCTATGATGTGCCCCCGGTTCGGGGGCTGCTTCCCAGCCAGTAT GGCCAGGAGGTGTATGACACACCCCCCATGGCTGTCAAGGGTCCCAATGGCCGAGACCCG TTGCTGGAGGTGTATGACGTGCCCCCCAGTGTGGAGAAGGGCCTGCCACCGTCCAACCAC CACGCAGTCTACGACGTTCCTCCATCGGTGAGCAAGGATGTGCCCGATGGCCCACTGCTG CGTGAGGAGACCTACGATGTGCCCCCCGCCTTCGCCAAGGCCAAGCCCTTTGACCCGGCC CGCACCCCACTGGTACTGGCTGCGCCCCCTCCAGACTCCCCGCCGGCCGAGGACGTGTAT GACGTGCCGCCCCCGGCTCCTGACCTCTACGACGTGCCCCCTGGCTTGCGGCGGCCTGGC CCGGGCACCCTGTACGATGTGCCCCGTGAACGGGTGCTTCCTCCTGAGGTGGCTGATGGT GGCGTGGTCGACAGTGGTGTGTATGCGGTGCCTCCCCCAGCTGAACGTGAAGCCCCGGCA GAGGGCAAGCGCCTGTCGGCCTCCAGCACCGGCAGCACACGCAGCAGCCAGTCTGCGTCC TCCTTGGAGGTGGCAGGGCCGGGCCGGGAACCCCTGGAGCTGGAAGTTGCTGTGGAGGCC CTGGCACGGCTGCAGCAGGGTGTGAGCGCCACCGTTGCCCACCTTCTGGACCTGGCAGGC AGCGCCGGTGCGACTGGGAGCTGGCGTAGCCCCTCTGAGCCACAGGAGCCGCTGGTGCAG GACCTGCAGGCTGCTGTGGCCGCTGTCCAGAGTGCCGTCCACGAGCTGTTGGAGTTTGCC CGCAGCGCGGTGGGCAATGCTGCCCACACATCTGACCGTGCCCTGCATGCCAAGCTTAGC CGGCAGCTGCAGAAGATGGAGGACGTGCACCAGACGCTGGTGGCACATGGTCAGGCCCTC GACGCTGGCCGGGGAGGCTCTGGAGCCACCCTTGAGGACCTGGACCGGCTGGTGGCCTGC TCGCGGGCTGTGCCCGAGGACGCCAAGCAGCTGGCCTCCTTCCTGCACGGCAATGCCTCA CTGCTCTTCAGACGGACCAAGGCCACTGCCCCGGGGCCTGAGGGGGGTGGCACCCTGCAC CCCAACCCCACTGACAAGACCAGCAGCATCCAGTCACGACCCCTGCCCTCACCCCCTAAG TTCACCTCCCAGGACTCGCCAGATGGGCAGTACGAGAACAGCGAGGGGGGCTGGATGGAG GACTATGACTACGTCCACCTACAGGGGAAGGAGGAGTTTGAGAAGACCCAGAAGGAGCTG CTGGAAAAGGGCAGCATCACGCGGCAGGGCAAGAGCCAGCTGGAGTTGCAGCAGCTGAAG CAGTTTGAACGACTGGAACAGGAGGTGTCACGGCCCATAGACCACGACCTGGCCAACTGG ACGCCAGCCCAACCCCTGGCCCCGGGGCGAACAGGCGGCCTGGGGCCCTCGGACCGGCAG CTGCTGCTCTTCTACCTGGAGCAGTGTGAGGCCAACCTGACCACACTGACCAACGCCGTG GACGCCTTCTTTACCGCCGTGGCCACCAACCAGCCGCCCAAGATCTTTGTGGCGCACAGC AAGTTCGTCATCCTCAGCGCCCACAAGCTGGTGTTCATCGGGGACACACTGTCACGGCAG GCCAAGGCTGCTGACGTGCGCAGCCAGGTGACCCACTACAGCAACCTGCTGTGCGACCTC CTGCGCGGCATCGTGGCCACCACCAAGGCCGCTGCCTTGCAGTACCCATCGCCTTCCGCG GCCCAGGACATGGTGGAGAGGGTCAAGGAGCTGGGCCACAGCACCCAGCAGTTCCGCCGC GTCCTAGGCCAGCTGGCAGCCGCCTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_001170715 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001170715.1, NP_001164186.1 |
| RefSeq Size | 3238 bp |
| RefSeq ORF | 2667 bp |
| Locus ID | 9564 |
| UniProt ID | P56945 |
| Protein Families | Druggable Genome |
| Protein Pathways | Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton |
| Gene Summary | The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017] Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC230560 | BCAR1 (Myc-DDK-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 2 |
CNY 9,410.00 |
|
| RC230560L3 | Lenti-ORF clone of BCAR1 (Myc-DDK-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 2 |
CNY 11,310.00 |
|
| RC230560L4 | Lenti-ORF clone of BCAR1 (mGFP-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 2 |
CNY 11,310.00 |
|
| RG230560 | BCAR1 (tGFP-tagged) - Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 2 |
CNY 10,360.00 |
