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SGOL2 (SGO2) (NM_001160033) Human Untagged Clone
CAT＃: SC327295
SGOL2 (untagged)-Human shugoshin-like 2 (S. pombe) (SGOL2) transcript variant 2
CNY 24,230.00
货期*
详询
规格
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经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SGOL2; TRIPIN |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_001160033, the custom clone sequence may differ by one or more nucleotides
ATGGAGTGCCCAGTGATGGAAACTGGCTCACTTTTTACCTCAGGAATTAAGAGACATTTG AAAGACAAAAGAATTTCAAAGACTACTAAGTTGAATGTTTCTCTTGCTTCAAAAATAAAA ACAAAAATACTAAATAATTCTTCTATTTTCAAAATATCTTTAAAGCACAACAACAGGGCA TTAGCTCAGGCTCTTAGTAGAGAAAAAGAGAATTCTCGAAGAATTACAACTGAAAAGATG CTATTGCAAAAAGAAGTAGAGAAACTGAATTTTGAGAACACATTTCTTCGCCTAAAGCTA AATAACTTGAATAAGAAGCTTATAGACATAGAAGCTCTCATGAACAATAACTTGATAACT GCAATTGAAATGAGCAGTCTTTCTGAGTTCCATCAGAGTTCCTTTCTACTGTCAGCTAGC AAGAAGAAACGAATTAGTAAACAGTGCAAGTTGATGCGTCTTCCATTTGCAAGGGTTCCA TTAACTTCAAATGATGATGAAGATGAAGATAAAGAGAAAATGCAGTGTGACAACAATATT AAATCAAAGACATTACCTGATATTCCCTCTTCAGGATCAACAACACAACCTTTATCAACT CAGGATAATTCGGAAGTGTTATTTCTTAAAGAAAATAATCAAAATGTATATGGTTTAGAT GATTCAGAACATATTTCTTCTATAGTTGATGTACCTCCCAGAGAAAGCCATTCCCACTCA GACCAAAGTTCTAAGACTTCTCTAATGAGTGAGATGAGAAACGCCCAGTCTATTGGCCGC AGATGGGAGAAACCATCTCCTAGTAATGTGACTGAAAGGAAGAAGCGTGGGTCATCTTGG GAATCAAATAATCTTTCTGCAGACACTCCCTGTGCAACAGTTTTAGATAAACAACACATT TCAAGTCCAGAATTAAATTGCAATAATGAGATAAATGGTCATACTAATGAAACAAATACT GAAATGCAAAGAAATAAACAGGATCTTCCTGGCTTATCTTCTGAGTCTGCCAGAGAACCT AATGCAGAGTGCATGAATCAAATTGAGGATAATGATGACTTTCAATTGCAGAAAACTGTG TATGATGCTGACATGGATTTAACTGCTAGTGAAGTCAGCAAAATTGTCACAGTCTCAACA GGCATTAAAAAGAAAAGTAATAAAAAAACAAATGAACATGGAATGAAAACTTTCAGAAAA GTGAAAGATTCCAGCTCTGAAAAAAAGAGAGAAAGATCAAAGAGACAGTTTAAAAATAGT TCAGATGTCGATATTGGGGAAAAGATTGAAAACAGGACAGAAAGATCTGATGTCCTGGAT GGCAAAAGGGGTGCAGAAGATCCCGGTTTTATTTTCAATAATGAACAGCTGGCTCAGATG AATGAACAGCTGGCTCAGGTGAATGAACTAAAGAAAATGACCCTTCAAACTGGCTTTGAA CAAGGTGACAGAGAAAATGTACTGTGTAATAAAAAGGAGAAAAGAATAACAAATGAGCAA GAGGAAACATACTCTTTATCCCAAAGTTCAGGTAAATTTCACCAGGAGAGTAAATTTGAT AAGGGTCAGAATTCCCTAACTTGTAATAAAAGTAAAGCTTCTAGACAGACATTTGTGATT CACAAATTAGAAAAAGATAACTTACTCCCAAACCAAAAGGATAAAGTAACCATTTATGAA AACCTAGACGTCACAAATGAATTTCACACAGCCAATCTTTCCACCAAAGATAATGGAAAT TTATGTGATTATGGGACCCACAATATATTGGATTTGAAAAAGTATGTCACTGATATTCAA CCCTCAGAGCAAAATGAATCAAACATTAATAAGCTTAGAAAGAAAGTAAACCGGAAGACA GAAATAATTTCTGGAATGAACCACATGTATGAGGATAATGATAAAGATGTGGTGCATGGC CTAAAAAAAGGTAATTTTTTTTTCAAAACCCAAGAGGATAAAGAACCTATCTCTGAAAAC ATAGAAGTTTCCAAAGAGCTTCAAATCCCAGCTCTTTCTACTAGAGATAATGAAAATCAA TGTGACTATAGGACCCAGAATGTGTTGGGTTTGCAAAAGCAGATCACCAATATGTACCCC GTTCAGCAAAATGAATCAAAAGTTAATAAGAAGCTTAGGCAGAAAGTAAATCGGAAGACA GAAATAATTTCTGAAGTGAATCATTTAGATAATGACAAAAGTATAGAATACACAGTTAAA AGTCACTCACTCTTTTTAACGCAAAAAGATAAGGAAATCATCCCTGGAAACCTAGAAGAC CCAAGTGAGTTTGAAACACCTGCTCTTTCTACCAAAGATAGTGGAAACCTGTATGATTCT GAGATTCAAAATGTTTTGGGGGTGAAACATGGCCATGATATGCAACCTGCTTGTCAAAAT GATTCAAAAATAGGTAAGAAGCCTAGACTAAATGTATGTCAAAAGTCAGAAATAATTCCT GAAACCAACCAAATATATGAGAATGATAACAAAGGTGTACATGACCTAGAAAAAGATAAC TTCTTCTCTCTAACCCCAAAGGATAAAGAAACAATTTCTGAAAATCTACAAGTCACAAAT GAATTTCAAACAGTTGATCTTCTCATCAAAGATAATGGAAATTTATGTGATTATGACACC CAGAATATATTGGAGTTGAAAAAGTATGTTACTGATAGGAAATCTGCTGAGCAAAATGAA TCAAAAATAAATAAGCTCAGGAATAAAGTGAATTGGAAGACAGAAATAATTTCTGAAATG AACCAGATATATGAGGATAATGATAAAGATGCACATGTCCAAGAAAGCTATACAAAAGAT CTTGATTTTAAAGTAAATAAATCTAAACAAAAACTTGAATGCCAAGACATTATCAATAAA CACTATATGGAAGTCAACAGTAATGAAAAGGAAAGTTGTGATCAAATTTTAGATTCCTAC AAAGTAGTTAAAAAACGTAAGAAAGAATCATCATGCAAGGCAAAGAACATTTTGACAAAA GCTAAGAACAAACTTGCTTCACAGTTAACAGAATCTTCACAGACATCTATCTCCTTAGAA TCTGATTTAAAACATATTACTAGTGAAGCAGATTCTGATCCAGGAAACCCAGTTGAACTA TGTAAGACTCAGAAGCAAAGCACTACCACTTTGAATAAAAAAGATCTCCCTTTTGTGGAA GAAATAAAAGAAGGAGAGTGTCAGGTTAAAAAGGTAAATAAAATGACATCTAAGTCAAAG AAAAGGAAGACCTCCATAGATCCTTCTCCAGAGAGCCATGAAGTAATGGAAAGAATACTT GACAGCGTTCAGGGAAAGTCTACTGTATCTGAACAAGCTGATAAGGAAAACAATTTGGAG AATGAGAAAATGGTCAAAAATAAGCCAGACTTTTACACAAAGGCATTTAGATCTTTGTCT GAGATACATTCACCTAACATACAAGATTCTTCCTTTGACAGTGTTCGTGAAGGTTTAGTA CCTTTGAGCGTTTCTTCTGGTAAAAATGTGATAATAAAAGAAAATTTTGCCTTGGAGTGC TCCCCAGCCTTTCAAGTAAGTGATGATGAGCATGAGAAGATGAACAAGATGAAATTTAAA GTCAACCGGAGAACCCAAAAATCAGGAATAGACCATTACAGGACTTGTCAAATACCAGTT TTGTTTCAAATAACACTGCTGAATCTGAAAATAAGTCAGAAGATCTATCTTCAGAACGGA CAAGCAGAAGAAGAAGGTGTACTCCTTTCTATTTTAAAGAGCCAAGCCTCAGAGACAAGA |
| Restriction Sites | Please inquire |
| ACCN | NM_001160033 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001160033.1, NP_001153505.1 |
| RefSeq Size | 4535 bp |
| RefSeq ORF | 3783 bp |
| Locus ID | 151246 |
| Gene Summary | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. |
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