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Neurexin 1 (NRXN1) (NM_001135659) Human Untagged Clone
CAT＃: SC326389
NRXN1 (untagged)-Human neurexin 1 (NRXN1), transcript variant alpha2
CNY 15,888.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | Hs.22998; PTHSL2; SCZD17 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001135659 edited
ATGGGGACGGCGCTGCTCCAGCGCGGGGGCTGTTTTCTTCTGTGCCTCTCGCTGCTGCTC CTGGGCTGCTGGGCGGAGCTGGGCAGCGGGCTGGAGTTTCCGGGCGCCGAGGGCCAATGG ACGCGCTTCCCCAAGTGGAACGCCTGCTGCGAGAGCGAGATGAGCTTCCAGCTCAAGACT CGCAGCGCCCGCGGCCTCGTGCTCTACTTCGACGACGAGGGCTTCTGCGACTTCCTGGAG CTGATTCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCTCCATCTTCTGCGCTGAGCCT GCGACGCTCCTGGCCGACACGCCGGTTAACGACGGCGCCTGGCACAGCGTGCGCATCCGC CGCCAGTTCCGCAACACCACGCTCTTCATCGACCAGGTGGAGGCCAAGTGGGTGGAGGTC AAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGCCTTTTCGTCGGGGGGCTGCCCCCG GAACTGCGCGCCGCGGCGCTCAAGCTCACCCTGGCCTCGGTGAGGGAGCGGGAGCCCTTC AAGGGGTGGATTCGTGACGTGAGGGTCAACTCCTCGCAGGTCCTGCCCGTGGACAGCGGC GAGGTGAAGCTGGACGATGAGCCGCCCAACAGCGGCGGGGGAAGCCCGTGCGAGGCGGGC GAGGAGGGCGAGGGCGGGGTGTGCCTCAACGGAGGTGTGTGCTCCGTGGTGGACGACCAG GCCGTGTGCGACTGCTCGCGAACCGGCTTCCGCGGCAAGGACTGCAGCCAAGAAATAAAA TTCGGTCTTCAGTGTGTTTTGCCGGTGCTGTTACATGACAATGACCAAGGAAAATACTGT TGTATAAATACAGCAAAGCCTCTAACAGAAAAAGACAACAATGTGGAAGGTCTGGCGCAC CTGATGATGGGCGACCAAGGTAAAAGTAAAGGAAAAGAAGAATATATTGCCACGTTCAAA GGATCTGAATACTTCTGCTACGACTTGTCTCAAAACCCCATTCAAAGCAGCAGTGATGAA ATAACTCTGTCATTTAAAACCCTTCAGAGGAATGGACTGATGCTTCACACTGGGAAATCG GCTGATTATGTCAATCTTGCCCTGAAAAATGGAGCTGTCTCTCTGGTCATTAATTTGGGA TCAGGGGCCTTTGAAGCACTAGTGGAGCCTGTGAATGGAAAGTTTAATGATAATGCCTGG CATGATGTGAAAGTCACCAGGAATCTGCGTCAGCACTCAGGCATTGGACACGCTATGGTA AACAAACTACATTGTTCGGTGACAATATCAGTGGATGGGATTCTTACCACAACGGGCTAC ACGCAAGAAGATTATACCATGCTGGGGTCTGATGACTTTTTCTATGTTGGAGGCAGTCCC AGCACAGCCGACCTTCCAGGGTCACCAGTCAGTAACAACTTTATGGGCTGTCTCAAAGAG GTTGTATATAAAAATAATGATGTGAGGCTGGAATTATCTCGACTTGCCAAGCAAGGAGAT CCTAAGATGAAGATCCATGGAGTGGTGGCATTTAAATGTGAGAATGTTGCAACTTTAGAC CCAATCACCTTTGAAACCCCAGAGTCTTTCATCTCTTTGCCTAAATGGAATGCAAAGAAA ACTGGCTCCATATCATTTGATTTCCGTACAACAGAGCCAAATGGCCTCATCTTATTTAGC CATGGCAAGCCAAGACATCAGAAAGATGCCAAGCACCCACAGATGATAAAGGTGGACTTC TTTGCTATTGAGATGCTAGATGGCCACCTCTACCTCCTCCTGGACATGGGGTCAGGTACT ATAAAAATAAAAGCCCTGTTGAAGAAAGTGAATGATGGAGAATGGTATCATGTGGACTTC CAGAGAGACGGACGGTCAGGTACCATTTCTGTCAACACGTTGCGTACTCCCTACACTGCT CCTGGTGAGAGTGAGATTCTGGACCTGGATGATGAGTTGTACCTGGGGGGGCTGCCAGAA AATAAAGCTGGCCTTGTCTTCCCCACCGAGGTGTGGACTGCTCTGCTCAACTATGGCTAC GTGGGCTGCATCAGGGATTTGTTCATCGATGGCCAAAGCAAAGATATCCGGCAAATGGCT GAAGTTCAAAGTACTGCTGGAGTGAAGCCTTCCTGCTCAAAGGAAACAGCAAAACCGTGC CTTAGCAACCCTTGCAAAAACAATGGCATGTGCAGGGATGGGTGGAACAGATATGTCTGT GATTGTTCCGGAACAGGCTATCTTGGCAGGTCCTGTGAGAGAGAGGCAACGGTTTTGAGC TATGATGGGAGCATGTTTATGAAAATTCAGCTCCCCGTAGTCATGCATACGGAGGCTGAG GATGTTTCCTTACGGTTCCGATCCCAGCGTGCATATGGCATTCTGATGGCAACCACTTCT AGAGACTCTGCTGACACCCTCCGCCTGGAGCTAGACGCAGGACGTGTGAAACTGACGGTC AATCTAGATTGTATCAGGATTAACTGTAATTCCAGCAAAGGTCCCGAGACTCTTTTTGCT GGCTATAACCTCAATGATAACGAGTGGCACACAGTGCGTGTAGTTCGGCGTGGAAAAAGT TTAAAGTTAACAGTGGATGACCAACAGGCCATGACAGGTCAAATGGCAGGTGATCATACT AGGCTGGAGTTCCATAACATAGAGACTGGCATCATCACAGAACGACGGTATCTTTCTTCT GTCCCCTCCAACTTCATTGGACACCTGCAGAGCTTGACATTTAATGGAATGGCATACATT GACCTGTGTAAAAATGGCGACATAGATTACTGTGAGCTTAATGCCAGATTTGGCTTCAGG AACATCATAGCAGATCCTGTCACCTTCAAGACCAAATCGAGCTATGTTGCCTTAGCTACC TTGCAAGCCTACACTTCTATGCATCTTTTTTTCCAGTTCAAGACAACATCCCTAGATGGA TTAATTCTATATAACAGTGGGGATGGAAATGACTTTATTGTGGTTGAATTAGTTAAAGGG TACTTACATTACGTGTTTGATTTGGGAAATGGTGCTAACCTCATCAAAGGAAGCTCAAAT AAACCTCTCAATGACAATCAGTGGCACAACGTGATGATATCAAGGGACACCAGCAACCTC CACACTGTAAAGATTGACACAAAAATCACAACGCAAATCACCGCCGGAGCCAGGAACTTA GACCTCAAGAGTGACTTATATATAGGAGGAGTAGCTAAAGAAACATACAAATCCTTACCA AAACTTGTACATGCCAAAGAAGGCTTTCAAGGCTGCCTGGCATCAGTTGATTTAAATGGA CGGCTTCCGGACCTCATCTCCGATGCTCTTTTCTGCAACGGACAGATCGAGAGAGGATGT GAAGGGCCCAGCACAACCTGCCAAGAGGACTCATGTTCCAATCAAGGTGTGTGCTTGCAA CAATGGGATGGCTTCAGCTGTGACTGTAGTATGACTTCCTTCAGTGGACCACTCTGCAAT GACCCTGGGACGACATATATCTTTAGCAAAGGTGGTGGACAAATCACGTATAAGTGGCCT CCTAATGACCGACCCAGTACACGAGCAGACAGACTGGCCATAGGTTTTAGCACTGTTCAG AAAGAAGCCGTATTGGTGCGAGTGGACAGTTCTTCAGGCTTGGGTGACTACCTAGAACTG CATATACACCAGGGAAAAATTGGAGTTAAGTTTAATGTTGGGACAGATGACATCGCCATT GAAGAATCCAATGCAATCATTAATGATGGGAAATACCATGTAGTTCGTTTCACGAGGAGT GGTGGCAATGCCACGTTGCAGGTGGACAGCTGGCCAGTGATCGAGCGCTACCCTGCAGGA AACAATGATAACGAGCGCCTGGCGATTGCTAGACAGCGAATTCCATATCGACTTGGTCGA GTAGTTGATGAATGGCTACTCGACAAAGGGCGTCAGCTCACAATCTTCAATAGCCAAGCA ACCATAATAATTGGCGGGAAAGAGCAGGGCCAGCCCTTCCAGGGCCAGCTCTCTGGGCTG TACTACAATGGCTTGAAAGTTCTGAATATGGCAGCCGAAAACGATGCCAACATCGCCATA GTGGGAAATGTGAGACTGGTTGGTGAAGTGCCTTCCTCTATGACAACTGAGTCAACAGCC ACTGCCATGCAATCAGAGATGTCCACATCAATTATGGAGACTACCACGACCCTGGCTACT AGCACAGCCAGAAGAGGAAAGCCCCCGACAAAAGAACCCATTAGCCAGACCACAGATGAC ATCCTTGTGGCCTCAGCAGAGTGTCCCAGCGATGATGAGGACATTGACCCCTGTGAGCCG AGCTCAGGTGGGTTAGCCAACCCAACCCGAGCAGGCGGCAGAGAGCCGTATCCAGGCTCA GCAGAAGTGATCCGGGAGTCCAGCAGCACCACGGGTATGGTCGTTGGGATAGTAGCCGCT GCCGCCCTGTGCATCCTTATCCTCCTCTATGCCATGTACAAGTACAGAAACCGGGATGAA GGCTCATACCATGTGGACGAGAGTCGAAACTACATCAGTAACTCAGCACAGTCCAATGGG GCTGTTGTAAAGGAGAAACAACCCAGCAGTGCGAAAAGCTCCAACAAAAATAAGAAAAAC AAGGATAAAGAGTATTATGTCTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_001135659 |
| Insert Size | 4600 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001135659.1, NP_001129131.1 |
| RefSeq Size | 9578 bp |
| RefSeq ORF | 4644 bp |
| Locus ID | 9378 |
| UniProt ID | Q9ULB1 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs) |
| Gene Summary | This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016] Transcript Variant: This variant (alpha2) results from the use of the 5'-most promoter, referred to as alpha. It represents the longest transcript that encodes the longest isoform (alpha2) of the representative RefSeq variants. This isoform contains EGF-like, several laminin G, and syndecan domains. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC226688 | NRXN1 (Myc-DDK-tagged)-Human neurexin 1 (NRXN1), transcript variant alpha2 |
CNY 15,880.00 |
|
| RC226688L1 | Lenti ORF clone of Human neurexin 1 (NRXN1), transcript variant alpha2, Myc-DDK-tagged |
CNY 18,280.00 |
|
| RC226688L2 | Lenti ORF clone of Human neurexin 1 (NRXN1), transcript variant alpha2, mGFP tagged |
CNY 15,680.00 |
|
| RC226688L3 | Lenti ORF clone of Human neurexin 1 (NRXN1), transcript variant alpha2, Myc-DDK-tagged |
CNY 15,680.00 |
|
| RC226688L4 | Lenti ORF clone of Human neurexin 1 (NRXN1), transcript variant alpha2, mGFP tagged |
CNY 15,680.00 |
|
| RG226688 | NRXN1 (tGFP-tagged) - Human neurexin 1 (NRXN1), transcript variant alpha2 |
CNY 17,480.00 |
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