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NMDAR2A (GRIN2A) (NM_001134408) Human Untagged Clone
CAT＃: SC325409
GRIN2A (untagged)-Human glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A), transcript variant 3
CNY 13,392.00
货期*
现货
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | EPND; FESD; GluN2A; LKS; NMDAR2A; NR2A |
| Vector | PCMV6-Neo |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>NCBI ORF sequence for NM_001134408, the custom clone sequence may differ by one or more nucleotides
ATGGGCAGAGTGGGCTATTGGACCCTGCTGGTGCTGCCGGCCCTTCTGGTCTGGCGCGGTCCGGCGCCGA GCGCGGCGGCGGAGAAGGGTCCCCCCGCGCTAAATATTGCGGTGATGCTGGGTCACAGCCACGACGTGAC AGAGCGCGAACTTCGAACACTGTGGGGCCCCGAGCAGGCGGCGGGGCTGCCCCTGGACGTGAACGTGGTA GCTCTGCTGATGAACCGCACCGACCCCAAGAGCCTCATCACGCACGTGTGCGACCTCATGTCCGGGGCAC GCATCCACGGCCTCGTGTTTGGGGACGACACGGACCAGGAGGCCGTAGCCCAGATGCTGGATTTTATCTC CTCCCACACCTTCGTCCCCATCTTGGGCATTCATGGGGGCGCATCTATGATCATGGCTGACAAGGATCCG ACGTCTACCTTCTTCCAGTTTGGAGCGTCCATCCAGCAGCAAGCCACGGTCATGCTGAAGATCATGCAGG ATTATGACTGGCATGTCTTCTCCCTGGTGACCACTATCTTCCCTGGCTACAGGGAATTCATCAGCTTCGT CAAGACCACAGTGGACAACAGCTTTGTGGGCTGGGACATGCAGAATGTGATCACACTGGACACTTCCTTT GAGGATGCAAAGACACAAGTCCAGCTGAAGAAGATCCACTCTTCTGTCATCTTGCTCTACTGTTCCAAAG ACGAGGCTGTTCTCATTCTGAGTGAGGCCCGCTCCCTTGGCCTCACCGGGTATGATTTCTTCTGGATTGT CCCCAGCTTGGTCTCTGGGAACACGGAGCTCATCCCAAAAGAGTTTCCATCGGGACTCATTTCTGTCTCC TACGATGACTGGGACTACAGCCTGGAGGCGAGAGTGAGGGACGGCATTGGCATCCTAACCACCGCTGCAT CTTCTATGCTGGAGAAGTTCTCCTACATCCCCGAGGCCAAGGCCAGCTGCTACGGGCAGATGGAGAGGCC AGAGGTCCCGATGCACACCTTGCACCCATTTATGGTCAATGTTACATGGGATGGCAAAGACTTATCCTTC ACTGAGGAAGGCTACCAGGTGCACCCCAGGCTGGTGGTGATTGTGCTGAACAAAGACCGGGAATGGGAAA AGGTGGGCAAGTGGGAGAACCATACGCTGAGCCTGAGGCACGCCGTGTGGCCCAGGTACAAGTCCTTCTC CGACTGTGAGCCGGATGACAACCATCTCAGCATCGTCACCCTGGAGGAGGCCCCATTCGTCATCGTGGAA GACATAGACCCCCTGACCGAGACGTGTGTGAGGAACACCGTGCCATGTCGGAAGTTCGTCAAAATCAACA ATTCAACCAATGAGGGGATGAATGTGAAGAAATGCTGCAAGGGGTTCTGCATTGATATTCTGAAGAAGCT TTCCAGAACTGTGAAGTTTACTTACGACCTCTATCTGGTGACCAATGGGAAGCATGGCAAGAAAGTTAAC AATGTGTGGAATGGAATGATCGGTGAAGTGGTCTATCAACGGGCAGTCATGGCAGTTGGCTCGCTCACCA TCAATGAGGAACGTTCTGAAGTGGTGGACTTCTCTGTGCCCTTTGTGGAAACGGGAATCAGTGTCATGGT TTCAAGAAGTAATGGCACCGTCTCACCTTCTGCTTTTCTAGAACCATTCAGCGCCTCTGTCTGGGTGATG ATGTTTGTGATGCTGCTCATTGTTTCTGCCATAGCTGTTTTTGTCTTTGAATACTTCAGCCCTGTTGGAT ACAACAGAAACTTAGCCAAAGGGAAAGCACCCCATGGGCCTTCTTTTACAATTGGAAAAGCTATATGGCT TCTTTGGGGCCTGGTGTTCAATAACTCCGTGCCTGTCCAGAATCCTAAAGGGACCACCAGCAAGATCATG GTATCTGTATGGGCCTTCTTCGCTGTCATATTCCTGGCTAGCTACACAGCCAATCTGGCTGCCTTCATGA TCCAAGAGGAATTTGTGGACCAAGTGACCGGCCTCAGTGACAAAAAGTTTCAGAGACCTCATGACTATTC CCCACCTTTTCGATTTGGGACAGTGCCTAATGGAAGCACGGAGAGAAACATTCGGAATAACTATCCCTAC ATGCATCAGTACATGACCAAATTTAATCAGAAAGGAGTAGAGGACGCCTTGGTCAGCCTGAAAACGGGGA AGCTGGACGCTTTCATCTACGATGCCGCAGTCTTGAATTACAAGGCTGGGAGGGATGAAGGCTGCAAGCT GGTGACCATCGGGAGTGGGTACATCTTTGCCACCACCGGTTATGGAATTGCCCTTCAGAAAGGCTCTCCT TGGAAGAGGCAGATCGACCTGGCCTTGCTTCAGTTTGTGGGTGATGGTGAGATGGAGGAGCTGGAGACCC TGTGGCTCACTGGGATCTGCCACAACGAGAAGAACGAGGTGATGAGCAGCCAGCTGGACATTGACAACAT GGCGGGCGTATTCTACATGCTGGCTGCCGCCATGGCCCTTAGCCTCATCACCTTCATCTGGGAGCACCTC TTCTACTGGAAGCTGCGCTTCTGTTTCACGGGCGTGTGCTCCGACCGGCCTGGGTTGCTCTTCTCCATCA GCAGGGGCATCTACAGCTGCATTCATGGAGTGCACATTGAAGAAAAGAAGAAGTCTCCAGACTTCAATCT GACGGGATCCCAGAGCAACATGTTAAAACTCCTCCGGTCAGCCAAAAACATTTCCAGCATGTCCAACATG AACTCCTCAAGAATGGACTCACCCAAAAGAGCTGCTGACTTCATCCAAAGAGGTTCCCTCATCATGGACA TGGTTTCAGATAAGGGGAATTTGATGTACTCAGACAACAGGTCCTTTCAGGGGAAAGAGAGCATTTTTGG AGACAACATGAACGAACTCCAAACATTTGTGGCCAACCGGCAGAAGGATAACCTCAATAACTATGTATTC CAGGGACAACATCCTCTTACTCTCAATGAGTCCAACCCTAACACGGTGGAGGTGGCCGTGAGCACAGAAT CCAAAGCGAACTCTAGACCCCGGCAGCTGTGGAAGAAATCCGTGGATTCCATACGCCAGGATTCACTATC CCAGAATCCAGTCTCCCAGAGGGATGAGGCAACAGCAGAGAATAGGACCCACTCCCTAAAGAGCCCTAGG TATCTTCCAGAAGAGATGGCCCACTCTGACATTTCAGAAACGTCAAATCGGGCCACGTGCCACAGGGAAC CTGACAACAGTAAGAACCACAAAACCAAGGACAACTTTAAAAGGTCAGTGGCCTCCAAATACCCCAAGGA CTGTAGTGAGGTCGAGCGCACCTACCTGAAAACCAAATCAAGCTCCCCTAGAGACAAGATCTACACTATA GATGGTGAGAAGGAGCCTGGTTTCCACTTAGATCCACCCCAGTTTGTTGAAAATGTGACCCTGCCCGAGA ACGTGGACTTCCCGGACCCCTACCAGGATCCCAGTGAAAACTTCCGCAAGGGGGACTCCACGCTGCCAAT GAACCGGAACCCCTTGCATAATGAAGAGGGGCTTTCCAACAACGACCAGTATAAACTCTACTCCAAGCAC TTCACCTTGAAAGACAAGGGTTCCCCGCACAGTGAGACCAGCGAGCGATACCGGCAGAACTCCACGCACT GCAGAAGCTGCCTTTCCAACATGCCCACCTATTCAGGCCACTTCACCATGAGGTCCCCCTTCAAGTGCGA TGCCTGCCTGCGGATGGGGAACCTCTATGACATCGATGAAGACCAGATGCTTCAGGAGACAGGGATGACC AACGCTTGGTTATTGGGAGATGCCCCTCGGACCCTTACAAACACTCGTTGCCATCCCAGGCGGTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_001134408 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001134408.1, NP_001127880.1 |
| RefSeq Size | 4745 bp |
| RefSeq ORF | 3846 bp |
| Locus ID | 2903 |
| UniProt ID | Q12879 |
| Protein Families | Druggable Genome, Ion Channels: Glutamate Receptors, Ion Channels: Sodium, Transmembrane |
| Protein Pathways | Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Long-term potentiation, Neuroactive ligand-receptor interaction, Systemic lupus erythematosus |
| Gene Summary | This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Transcript Variant: This variant (3) has a shorter 5' UTR and is alternatively spliced at the 3' end, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC226377 | GRIN2A (Myc-DDK-tagged)-Human glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A), transcript variant 3 |
CNY 12,830.00 |
|
| RC226377L3 | Lenti-ORF clone of GRIN2A (Myc-DDK-tagged)-Human glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A), transcript variant 3 |
CNY 14,730.00 |
|
| RC226377L4 | Lenti-ORF clone of GRIN2A (mGFP-tagged)-Human glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A), transcript variant 3 |
CNY 14,730.00 |
|
| RG226377 | GRIN2A (tGFP-tagged) - Human glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A), transcript variant 3 |
CNY 14,160.00 |
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