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SMC6L1 (SMC6) (NM_001142286) Human Untagged Clone
CAT＃: SC325391
SMC6 (untagged)-Human structural maintenance of chromosomes 6 (SMC6), transcript variant 1
CNY 7,608.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | hSMC6; SMC-6; SMC6L1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC325391 representing NM_001142286.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGCCAAAAGAAAGGAAGAAAATTTTTCCTCTCCTAAAAATGCCAAAAGGCCAAGACAAGAAGAATTG GAGGATTTTGATAAAGATGGTGACGAAGACGAATGTAAAGGTACTACTTTGACTGCAGCAGAAGTTGGA ATAATTGAGAGTATTCACCTAAAAAACTTCATGTGTCATTCAATGCTTGGACCTTTTAAGTTTGGTTCT AATGTCAACTTTGTTGTTGGCAACAATGGAAGTGGGAAGAGTGCAGTACTCACAGCTCTCATAGTCGGT CTTGGTGGAAGAGCAGTTGCTACTAATAGAGGATCCTCTTTAAAAGGTTTTGTGAAAGATGGACAGAAC TCTGCAGATATCTCAATAACATTGAGGAACAGAGGAGATGATGCCTTTAAAGCCAGTGTGTATGGTAAC TCTATACTTATACAGCAACACATCAGCATAGATGGAAGTCGATCTTATAAACTTAAAAGTGCAACAGGC TCCGTGGTTTCCACGAGGAAAGAAGAGCTGATTGCAATTCTTGATCATTTTAACATCCAGGTGGATAAT CCAGTTTCTGTTTTAACACAAGAAATGAGCAAGCAGTTCTTACAGTCTAAAAATGAAGGAGACAAATAC AAATTCTTCATGAAAGCAACGCAACTTGAACAGATGAAGGAAGATTATTCATACATTATGGAAACGAAA GAAAGAACAAAGGAGCAGATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAGTGTGTAGAG AAAGAGGAACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACAT GAAATGGCTTGGGCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAATATCAAAATT GGAGAAGATCGTGCTGCTAGACTTGACAGGAAAATGGAAGAACAGCAGGTCAGACTTAATGAGGCAGAA CAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAGTGAAGAGACAAATGCACGAGCACCAGAA TGTATGGCATTGAAAGCAGATGTTGTTGCTAAGAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAAC CGATCCTTAAACGAATATAAAGCATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTG AAAAAAAGTACTGACCAATCTTTGGAACCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAA GAGAGAGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAGATCGAACAGTTTCAGCAAGCC ATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAAGCATGCACTGAGC TACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCGACTCAAAAGATTTGGCCCTAAT GTTCCAGCTCTTCTTGAAGCCATAGATGATGCTTATAGACAAGGACATTTTACCTATAAACCTGTAGGC CCTTTAGGAGCTTGCATTCATCTTCGGGACCCAGAACTTGCTTTGGCTATTGAATCTTGCTTAAAAGGG CTTCTGCAGGCCTATTGTTGCCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAAAGGTTT TATTTACCAGGGACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGA CACAGAGCTGCTTATCATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGCGGTTGTG GCAAATAGCCTAATTGACATGAGAGGCATAGAGACAGTGCTACTAATCAAAAATAATTCTGTAGCTCGT GCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGCTTTTACTGCTGATGGTGATCAAGTT TTTGCAGGACGTTATTATTCATCTGAAAATACAAGACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAA ATAAGTGACTTGGAGAATGAGGTTGAAAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCT GCCCTTGAAAAAGATATTAAACACAATGAGGAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTA AAGATGAAAATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATAGAAGAACACCAGTCTGTA GATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGAGGAACATATG GAGCAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGCAGAAAATAAGTATGATGCA ATTAAATTCAAAATTAATCAACTATCGGAGCTAGCAGACCCACTTAAGGATGAATTAAACCTTGCTGAT TCTGAAGTGGATAACCAAAAACGAGGGAAACGACATTATGAAGAAAAACAAAAAGAACACTTGGATACC TTAAATAAAAAGAAACGAGAACTGGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCAAGA CAAATCTGCCCAGAGCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTA AGGCAGAAGATACAGGCAGAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCAAGAA GCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGGACTTTAAAAAAGTTTATTAAATTACTGGGA GAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTGTTTGACTTTACGATGCAAATTA TACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGGAAAAATGAATTTTGACCACAAGAATGAAACT CTAAGTATATCAGTTCAGCCTGGAGAAGGAAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGA GGTGAACGTTCTTTCTCCACAGTGTGTTTTATTCTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGA TGCCTGGATGAATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATGGACTTGATACTGAAG ATGGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACTTCCATCC AGTAAACTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTACATTGCCTTTCAGACCT GTGACTCAAGAAGAAGATGATGACCAAAGGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001142286 |
| Insert Size | 3276 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001142286.1 |
| RefSeq Size | 5275 bp |
| RefSeq ORF | 3276 bp |
| Locus ID | 79677 |
| UniProt ID | Q96SB8 |
| MW | 126.3 kDa |
| Gene Summary | Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC227064 | SMC6 (Myc-DDK-tagged)-Human structural maintenance of chromosomes 6 (SMC6), transcript variant 1 |
CNY 11,392.00 |
|
| RC227064L3 | Lenti ORF clone of Human structural maintenance of chromosomes 6 (SMC6), transcript variant 1, Myc-DDK-tagged |
CNY 10,260.00 |
|
| RC227064L4 | Lenti ORF clone of Human structural maintenance of chromosomes 6 (SMC6), transcript variant 1, mGFP tagged |
CNY 10,260.00 |
|
| RG227064 | SMC6 (tGFP-tagged) - Human structural maintenance of chromosomes 6 (SMC6), transcript variant 1 |
CNY 12,992.00 |
