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Ankyrin brain (ANK2) (NM_001127493) Human Untagged Clone
CAT＃: SC323291
ANK2 (untagged)-Human ankyrin 2, neuronal (ANK2), transcript variant 3
CNY 35,910.00
货期*
8周
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ANK-2; brank-2; CFAP87; FAP87; LQT4 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001127493, the custom clone sequence may differ by one or more nucleotides
ATGACCACCATGTTGCAAAAGTCTGACAGCAATGCAAGCTTCCTCCGTGCTGCCAGAGCA GGCAACCTGGACAAAGTTGTGGAATATCTGAAGGGGGGCATAGACATCAATACCTGCAAT CAGAATGGACTCAACGCTCTCCATCTGGCTGCCAAGGAAGGCCACGTGGGGCTGGTGCAG GAGCTGCTGGGAAGAGGGTCCTCTGTGGATTCTGCCACTAAGAAGGGAAATACCGCTCTT CACATTGCATCTTTGGCTGGACAAGCAGAAGTTGTCAAAGTTCTTGTTAAGGAAGGAGCC AATATTAATGCACAGTCTCAGAATGGCTTTACTCCTTTATACATGGCTGCCCAAGAGAAT CACATTGATGTTGTAAAATATTTGCTGGAAAATGGAGCTAATCAGAGCACTGCTACAGAG GATGGCTTTACTCCTCTAGCTGTGGCACTCCAGCAAGGACACAACCAGGCGGTGGCCATC CTCTTGGAGAATGACACCAAAGGGAAAGTGAGGCTGCCAGCTCTGCATATTGCCGCTAGG AAAGACGACACCAAATCTGCCGCACTTCTGCTTCAGAATGACCACAATGCTGACGTACAA TCCAAGATGATGGTGAATAGGACAACTGAGAGTGGTTTTACCCCTTTGCACATAGCTGCA CATTACGGAAATGTCAACGTGGCAACTCTTCTTCTAAACCGGGGAGCTGCTGTGGACTTC ACAGCCAGGAATGGAATCACTCCTCTGCATGTGGCTTCCAAAAGAGGAAATACAAACATG GTGAAGCTCTTACTGGATCGAGGCGGTCAGATCGATGCCAAAACTAGGGATGGGTTGACA CCACTTCACTGTGCTGCACGAAGTGGGCATGACCAAGTGGTGGAACTTCTGTTGGAACGG GGTGCCCCCTTGCTGGCAAGGACTAAGAATGGGCTGTCTCCACTACACATGGCTGCCCAG GGAGACCACGTGGAATGTGTGAAGCACCTGTTACAGCACAAGGCACCTGTTGATGATGTC ACCCTAGACTACCTGACAGCCCTCCACGTTGCTGCGCACTGTGGCCACTACCGTGTAACC AAACTCCTTTTAGACAAGAGAGCCAATCCGAACGCCAGAGCCCTGAATGGTTTTACTCCA CTGCACATTGCCTGCAAGAAAAACCGCATCAAAGTCATGGAACTGCTGGTGAAATATGGG GCTTCAATCCAAGCTATAACAGAGTCTGGCCTCACACCAATACATGTGGCTGCCTTCATG GGCCACTTGAACATTGTCCTCCTTCTGCTGCAGAACGGAGCCTCTCCAGATGTCACTAAC ATTCGTGGTGAGACGGCACTACACATGGCAGCCCGAGCCGGGCAGGTGGAAGTGGTCCGA TGCCTCCTGAGAAATGGTGCCCTTGTTGATGCCAGAGCCAGGGAGGAACAGACACCTTTA CATATTGCCTCCCGCCTGGGTAAGACAGAAATTGTCCAGCTGCTTCTACAACATATGGCT CATCCAGATGCGGCCACTACAAATGGGTACACACCACTGCACATCTCTGCCCGGGAGGGC CAGGTGGATGTGGCATCAGTCCTATTGGAAGCAGGAGCAGCCCACTCCTTAGCTACCAAG AAGGGTTTTACTCCCCTGCATGTAGCAGCCAAGTATGGAAGCCTGGATGTGGCAAAACTT CTCTTGCAACGCCGTGCTGCCGCAGATTCTGCAGGGAAGAACGGCCTTACCCCGCTCCAT GTTGCTGCTCATTATGACAACCAGAAGGTGGCGCTGCTGTTACTGGAGAAGGGTGCTTCC CCTCATGCCACTGCCAAGAATGGCTATACTCCGTTACATATTGCTGCCAAGAAGAATCAA ATGCAGATAGCTTCCACACTCCTGAACTATGGAGCAGAGACAAACATTGTGACAAAGCAA GGAGTAACTCCACTCCATCTGGCCTCGCAGGAGGGGCACACAGATATGGTTACCTTGCTT CTGGATAAGGGAGCCAATATCCACATGTCAACTAAGAGTGGACTCACATCCTTACACCTT GCAGCCCAGGAAGATAAAGTGAATGTTGCTGATATTCTCACCAAGCATGGAGCTGATCAG GATGCTCATACAAAGCTTGGTTACACACCTTTAATTGTGGCCTGTCACTATGGAAATGTG AAAATGGTCAACTTTCTTCTGAAGCAGGGAGCAAATGTTAACGCAAAAACCAAGAACGGC TACACGCCTTTGCACCAGGCCGCTCAGCAGGGTCACACGCACATCATCAACGTCCTGCTC CAGCATGGGGCCAAGCCCAACGCCACCACTGCGAATGGCAACACTGCCTTGGCGATTGCT AAGCGTCTGGGCTACATCTCCGTGGTCGACACCCTGAAGGTTGTGACTGAGGAGGTCACC ACCACCACCACAACTATTACAGAAAAACACAAACTAAATGTACCTGAGACGATGACTGAG GTTCTTGATGTTTCTGATGAAGAGGGTGATGACACAATGACTGGTGATGGGGGAGAATAC CTTAGGCCTGAGGACCTAAAAGAACTGGGTGATGACTCACTACCCAGCAGTCAGTTCCTG GATGGTATGAATTACCTGCGATACAGCTTGGAGGGAGGACGATCTGACAGCCTTCGATCC TTCAGTTCCGACAGGTCTCACACTCTGAGCCATGCCTCCTACCTGAGGGACAGTGCCGTG ATGGATGACTCAGTTGTGATTCCCAGTCACCAGGTGTCAACTCTAGCCAAGGAGGCAGAA AGGAATTCTTATCGCCTAAGCTGGGGCACTGAGAACTTAGACAACGTGGCTCTTTCTTCT AGTCCTATTCATTCAGGCCGCGCCTCTCCATGTCTTGAACGTGACAACAGCAGTTTCCTG GTTAGTTTTATGGTGGATGCCCGAGGTGGTGCTATGCGAGGATGCAGACACAATGGGCTC CGAATCATTATTCCACCTCGGAAATGTACTGCTCCAACGCGAGTCACCTGCCGACTGGTC AAGCGCCACAGACTGGCAACAATGCCTCCAATGGTGGAAGGAGAAGGCCTGGCCAGTCGC CTGATCGAAGTTGGACCTTCTGGTGCTCAGTTCCTTGGTAAACTTCACCTGCCAACGGCT CCTCCCCCACTTAATGAGGGAGAAAGTTTGGTCAGCCGCATTCTTCAGCTGGGGCCTCCT GGAACCAAATTCCTTGGGCCTGTGATCGTGGAGATCCCTCACTTTGCGGCCCTTCGAGGA AAGGAAAGGGAACTGGTGGTCCTGCGCAGTGAGAATGGGGACAGCTGGAAAGAGCATTTC TGTGACTACACTGAAGATGAATTGAATGAAATTCTTAACGGCATGGATGAAGTACTGGAT AGCCCAGAAGACCTAGAAAAGAAACGAATCTGCCGCATCATCACCCGAGACTTCCCACAG TACTTTGCAGTGGTGTCTCGTATCAAACAGGACAGCAATCTGATTGGCCCAGAAGGAGGT GTACTGAGCAGCACAGTGGTGCCCCAGGTGCAGGCCGTCTTCCCAGAGGGGGCACTCACC AAGCGGATCCGCGTAGGCCTGCAGGCTCAACCTATGCACAGTGAGCTGGTTAAGAAGATC CTAGGCAACAAAGCTACCTTCAGCCCTATAGTCACTTTGGAACCTAGAAGAAGAAAATTC CACAAACCAATTACCATGACCATTCCTGTCCCCAAAGCTTCAAGTGATGTCATGTTGAAT GGTTTTGGGGGAGATGCACCAACCTTAAGATTACTATGCAGCATAACAGGTGGAACCACC CCTGCCCAGTGGGAAGATATTACAGGAACTACGCCATTAACATTTGTCAATGAATGTGTT TCCTTTACAACAAACGTGTCTGCCAGGTTCTGGCTGATAGATTGTCGACAGATCCAGGAA TCCGTTACTTTTGCATCACAAGTATACAGAGAAATTATCTGCGTACCTTATATGGCCAAA TTTGTAGTGTTTGCCAAATCACATGACCCCATTGAAGCCAGGTTGAGGTGTTTCTGCATG ACTGATGATAAAGTGGATAAGACCCTTGAACAACAAGAAAATTTTGCTGAGGTGGCCAGA AGCAGGGATGTGGAGGTGTTAGAAGGAAAACCCATCTACGTTGATTGTTTCGGCAACTTG GTACCATTAACTAAAAGTGGCCAGCATCATATATTCAGTTTTTTTGCCTTCAAAGAAAAT AGACTTCCTCTATTTGTCAAGGTACGCGATACGACTCAGGAACCTTGCGGACGACTATCA TTTATGAAGGAGCCAAAATCCACGAGAGGCCTGGTGCATCAAGCTATTTGCAACTTAAAC ATCACTTTGCCGATTTATACAAAGGAATCAGAGTCAGATCAAGAACAGGAGGAAGAGATC GATATGACATCAGAAAAAAATCCACAGGATGAGCAGGAACGGATCGAGGAAAGGCTGGCT TATATTGCTGATCACCTTGGCTTCAGCTGGACAGAATTAGCAAGAGAACTGGATTTCACT GAGGAGCAAATTCATCAAATTCGAATTGAAAATCCCAACTCTCTTCAAGACCAGAGTCAT GCACTGTTGAAGTACTGGCTAGAGAGGGATGGGAAACATGCTACAGATACCAACCTCGTT GAATGTCTCACCAAGATCAACCGAATGGATATTGTTCATCTCATGGAGACCAACACAGAA CCTCTCCAGGAGCGCATCAGTCATAGTTATGCAGAAATTGAACAGACCATTACACTGGAT CATAGTGAAGGGTTCTCGGTACTTCAAGAGGAGTTATGCACTGCACAGCACAAGCAGAAA GAGGAGCAAGCTGTTTCTAAAGAAAGTGAGACCTGCGATCACCCTCCTATCGTCTCAGAG GAAGACATTTCTGTTGGTTATTCCACTTTTCAGGATGGCGTCCCCAAAACTGAGGGGGAC AGCTCAGCAACAGCACTCTTTCCCCAAACTCACAAGGAGCAAGTTCAACAGGATTTCTCA GGGAAAATGCAAGACCTGCCTGAAGAGTCATCTCTGGAATATCAGCAGGAATATTTTGTG ACAACTCCAGGAACAGAAACATCAGAGACTCAGAAGGCTATGATAGTACCCAGCTCTCCC AGCAAGACACCTGAGGAAGTTAGCACCCCTGCAGAGGAGGAGAAGCTGTACCTCCAGACC CCAACATCCAGCGAGCGGGGAGGCTCTCCCATCATACAAGAACCCGAAGAGCCCTCAGAG CACAGAGAGGAGAGCTCTCCGCGGAAAACCAGCCTCGTAATAGTGGAGTCTGCCGATAAC CAGCCTGAGACCTGTGAAAGACTCGATGAAGATGCAGCTTTTGAAAAGGGAGACGATATG CCTGAAATACCCCCAGAAACAGTCACAGAAGAAGAATACATTGATGAGCATGGACACACC GTGGTAAAGAAGGTTACTAGGAAAATCATTAGGCGGTATGTATCCTCTGAAGGCACAGAG AAAGAAGAGATTATGGTGCAGGGAATGCCACAGGAACCTGTCAACATCGAGGAAGGGGAT GGCTATTCCAAAGTTATAAAGCGTGTTGTATTGAAGAGTGACACCGAGCAGTCAGAGGAC AACAATGAG |
| Restriction Sites | Please inquire |
| ACCN | NM_001127493 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001127493.1, NP_001120965.1 |
| RefSeq Size | 8082 bp |
| RefSeq ORF | 5592 bp |
| Locus ID | 287 |
| UniProt ID | Q01484 |
| Protein Families | Druggable Genome |
| Gene Summary | This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011] Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1, resulting in a shorter isoform (3) that has a distinct N-terminus. |
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