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CYP1A1 (NM_000499) Human Untagged Clone
CAT＃: SC322548
CYP1A1 (untagged)-Human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1)
CNY 5,728.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for SC322548
GTGATCCCAGGCTCCAAGAGTCCACCCTTCCCAGCTCAGCTCAGTACCTCAGCAGCCACC
TCCAAGATCCCTACACTGATCATGCTTTTCCCAATCTCCATGTCGGCCACGGAGTTTCTT CTGGCCTCTGTCATCTTCTGTCTGGTATTCTGGGTAATCAGGGCCTCAAGACCTCAGGTC CCCAAAGGCCTGAAGAATCCACCAGGGCCATGGGGCTGGCCTCTGATTGGGCACATGCTG ACCCTGGGAAAGAACCCGCACCTGGCACTGTCAAGGATGAGCCAGCAGTATGGGGACGTG CTGCAGATCCGAATTGGCTCCACACCCGTGGTGGTGCTGAGCGGCCTGGACACCATCCGG CAGGCCCTGGTGCGGCAGGGCGATGATTTCAAGGGCCGGCCCGACCTCTACACCTTCACC CTCATCAGTAATGGTCAGAGCATGTCCTTCAGCCCAGACTCTGGACCAGTGTGGGCTGCC CGCCGGCGCCTGGCCCAGAATGGCCTGAAAAGTTTCTCCATTGCCTCTGACCCAGCCTCC TCAACCTCCTGCTACCTGGAAGAGCATGTGAGCAAGGAGGCTGAGGTCCTGATAAGCACG TTGCAGGAGCTGATGGCAGGGCCTGGGCACTTTAACCCCTACAGGTATGTGGTGGTATCA GTGACCAATGTCATCTGTGCCATTTGCTTTGGCCGGCGCTATGACCACAACCACCAAGAA CTGCTTAGCCTAGTCAACCTGAATAATAATTTCGGGGAGGTGGTTGGCTCTGGAAACCCA GCTGACTTCATCCCTATTCTTCGCTACCTACCCAACCCTTCCCTGAATGCCTTCAAGGAC CTGAATGAGAAGTTCTACAGCTTCATGCAGAAGATGGTCAAGGAGCACTACAAAACCTTT GAGAAGGGCCACATCCGGGACATCACAGACAGCCTGATTGAGCACTGTCAGGAGAAGCAG CTGGATGAGAACGCCAATGTCCAGCTGTCAGATGAGAAGATCATTAACATCGTCTTGGAC CTCTTTGGAGCTGGGTTTGACACAGTCACAACTGCTATCTCCTGGAGCCTCATGTATTTG GTGATGAACCCCAGGGTACAGAGAAAGATCCAAGAGGAGCTAGACACAGTGATTGGCAGG TCACGGCGGCCCCGGCTCTCTGACAGATCCCATCTGCCCTATATGGAGGCCTTCATCCTG GAGACCTTCCGACACTCTTCCTTCGTCCCCTTCACCATCCCCCACAGCACAACAAGAGAC ACAAGTTTGAAAGGCTTTTACATCCCCAAGGGGCGTTGTGTCTTTGTAAACCAGTGGCAG ATCAACCATGACCAGAAGCTATGGGTCAACCCATCTGAGTTCCTACCTGAACGGTTTCTC ACCCCTGATGGTGCTATCGACAAGGTGTTAAGTGAGAAGGTGATTATCTTTGGCATGGGC AAGCGGAAGTGTATCGGTGAGACCATTGCCCGCTGGGAGGTCTTTCTCTTCCTGGCTATC CTGCTGCAACGGGTGGAATTCAGCGTGCCACTGGGCGTGAAGGTGGACATGACCCCCATC TATGGGCTAACCATGAAGCATGCCTGCTGTGAGCACTTCCAAATGCAGCTGCGCTCTTAG GTGCTTGAGAGCCCTGAGGCCTAGACTCTGTCTACCTGGTCTGGTTGGGCAGCCAGACCA GCAGGCTGGCCTATGTGGTCTAAGGTTCAGCCTGAAACTCATAGACACTGATCTGGCTGC AGTTTTGCTATCTGGGCTGTGGGCAAGCCTAAGGGATCCTGCCTGCCCCTACCCTGGACT TGCCTCTGCACACCCTCCAGAGACAACAGGTAAAACAGGGCCACATAGATGCTGATGGAG CCTTCCCAAGTTGTGCTTGAGCCAGGAGGCCTGCTAGGGTTAGGAGGTCCTTAGGCCTCT GAGAAGCTCTGAAGAACTCTCTGGAAGCCCCTGGGCCCAGTACCTAGCTGGCTCTGTGAG GGTGCTGACTGGCTTCAGCAAGTTAGAACTAGCCAAACCAGGACCCTGTCCAATCTTTGA CAATTGGGAGCTGCCAAGAGTGAAGGGAAGAGACAGCCCAGGATACTGGCACAGAGGTAG TCTCACTGCTTGAACTAGGCTGAGCAATCTGACCCTATGGGTCTAGGACACAGTTCCTGG GAACATCACATTCCTCTGCCCTTCCTGCAGGCAGGAACAAACAGGGCTGCCTTCTGGCCT TGTAAGACCCTTATTGCTGTCCTGGAGGGGCTGGGGACTTGTGTCTGCGGGGATCAGAGC GCACAGGGAGTGCACATATCCAGGCACCAGGACTAGGGCTGGAGTGAGGGGGGGGTATTT CAATTACCTTCTATTGGTCTCCCTTCTCTACACTCTTGTAATAAAATGTCTATTTTTAAT GTTTGTACACAACAATCCTTCTATTCTAGCCTGCATTGAGCTTGCATGCTTGCATAAGAG CTTAAGAACCATTGATTTAATGTAATAGGGAAAATTCTAACCCAGGTATCCAAAAATGTG TAAGAACAACTACCTGAGCTAAATAAAGATATTGTTCAGAAATCCTAAAAAAAAAAAAAA AAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_000499 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000499.2, NP_000490.1 |
| RefSeq Size | 2602 bp |
| RefSeq ORF | 1539 bp |
| Locus ID | 1543 |
| UniProt ID | P04798 |
| Domains | p450 |
| Protein Families | Druggable Genome, P450, Transmembrane |
| Protein Pathways | Metabolism of xenobiotics by cytochrome P450, Retinol metabolism, Tryptophan metabolism |
| Gene Summary | This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016] Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells
,Fortin, S;Charest-Morin, X;Turcotte, V;Lauvaux, C;Lacroix, J;Côté, MF;Gobeil, S;C-Gaudreault, R;,
J. Med. Chem.
,PubMed ID 28535350
[CYP1A1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205760 | CYP1A1 (Myc-DDK-tagged)-Human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) |
CNY 5,720.00 |
|
| RC205760L1 | Lenti ORF clone of Human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), Myc-DDK-tagged |
CNY 8,120.00 |
|
| RC205760L2 | Lenti ORF clone of Human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mGFP tagged |
CNY 6,460.00 |
|
| RC205760L3 | Lenti ORF clone of Human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), Myc-DDK-tagged |
CNY 8,120.00 |
|
| RC205760L4 | Lenti ORF clone of Human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mGFP tagged |
CNY 8,120.00 |
|
| RG205760 | CYP1A1 (tGFP-tagged) - Human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) |
CNY 7,320.00 |
|
| SC119858 | CYP1A1 (untagged)-Human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) |
CNY 5,728.00 |
