United States
Germany
Japan
United Kingdom
China
Rab5 (RAB5A) (NM_004162) Human Untagged Clone
CAT＃: SC322309
RAB5A (untagged)-Human RAB5A, member RAS oncogene family (RAB5A)
CNY 3,600.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | RAB5 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for SC322309
CTAAGAGCAGGCGACGCCGCCGCCGCCACCACCACCGCCATAGATACACTCTCATCCTAC
GGGCCACGCCTGGGCCTTGCTGCCAGGAAGCTTCGGCCCCGCAGCTCGGCTTGCTGCGGT CTCAGGTTTCTTTACCTCCAGAAAGAAGAATATTGGCCCCTTGAATTCTGGAAGTTCATT GAAGAGTCTGAAATTAGGGACTTATTTCAAATTTGGACATGGCTAGTCGAGGCGCAACAA GACCCAACGGGCCAAATACTGGAAATAAAATATGCCAGTTCAAACTAGTACTTCTGGGAG AGTCCGCTGTTGGCAAATCAAGCCTAGTGCTTCGTTTTGTGAAAGGCCAATTTCATGAAT TTCAAGAGAGTACCATTGGGGCTGCTTTTCTAACCCAAACTGTATGTCTTGATGACACTA CAGTAAAGTTTGAAATATGGGATACAGCTGGTCAAGAACGATACCATAGCCTAGCACCAA TGTACTACAGAGGAGCACAAGCAGCCATAGTTGTATATGATATCACAAATGAGGAGTCCT TTGCAAGAGCAAAAAATTGGGTTAAAGAACTTCAGAGGCAAGCAAGTCCTAACATTGTAA TAGCTTTATCGGGAAACAAGGCCGACCTAGCAAATAAAAGAGCAGTAGATTTCCAGGAAG CACAGTCCTATGCAGATGACAATAGTTTATTATTCATGGAGACATCCGCTAAAACATCAA TGAATGTAAATGAAATATTCATGGCAATAGCTAAAAAATTGCCAAAGAATGAACCACAAA ATCCAGGAGCAAATTCTGCCAGAGGAAGAGGAGTAGACCTTACCGAACCCACACAACCAA CCAGGAATCAGTGTTGTAGTAACTAAACCTCTAGTTTGAACTAGCTGGAATAGTCTTCTG CTTCCTAAATGTTAATAACAATGGAATTGGAGCATTTAACCAGCCCAGTATGACTTCCAA AAGAAGAGACTTATGATAGAGTCAAGTTTCTAATACAGAATTATTTTAAGTGTTTTGAAC TTAATTTTTAATAACATGCATGGGTCCCTCTCACTAATGTTTCAACAATAGGGAAAAATG AGAACTATGTGGACACTTGTTTCATTGGAAGGTTAGGGGGAATAATTTCTCATCACTAGG AATATAGACAAATGACTGTCTGGGCCCACACAGTTAACCAGCCCATTTCTCCACACTGGT ACAGTAGTCACCTGTGAAAAAAAAAATTGGAACTTACTAATTTGGGCTTTTCAAAAACAT TCTTTGTTTAGAAGGAGATTCTAAAGTTATTTATGATGCTTAGCCATAGTATTCAGGCAA ATGTTCATTTCTCCTGGTACCTGTATTTAAAATGTACATTCCACATTTTAATAAATTAAC CACAAGAAAATAATCCCACATATACAAGGTCAGGGGTGGGGAAGAGTATTAATGGTATCT TAATTATACCCAGTCTGGTTTTTTTTTTTTAAATGGGGTAAAAATCAAATGCAACCCCAT CTTGTTTTAGGAATTTTGAGAACTAATAAATGCACCTTAATGGTCAGTGTTCCTTTCAAA CATGTGAGTTCTTTAACAAAAATGAAATAAACCAGGTGTCTGTGATTTCTAATTAATCAC CGCTGGCCATTACACAGGTTTTGTTGTTTGGGGTGGGGAGGGGGCTTTTGTTCCCTTTTG ACATAATATAGTCAATGCACTAACAATTATGTATATTCAAACTTGATTATTTTAAATTCG ATCTTCAGCTGTACTGTAAATAGGGTACTGCATTGTAGTCTCCATATCTGTATTACTTTT CTGTAATATTTAAGAGTTGCTTAAAAGCATACAAAATGTACTGTTACTAAAACAGCTAAT TATTTCTCTCTCCCCCTTTGACAGGAAGGGGCTTCAGTTGTTCCTCCATGGCTAGAACCA TAATAAACAATGTACCCGTAATTTGTAACATAAAGTATTGCAATATGTTAGTAACAATCT TGCAGCCTTCCTTTCCAAAGTTCATTTTATTTTGATCAGTTCAGTATATTGCACTAATTA TTTTAGGTATTTTCATTATATGAAAGCTACCATGTGTCAGAGATGATTTAATCTATTTAA GTGTTGGACTGCTAGGAGAACTTGTACATTTATGATAATGCAGAATTAGGAAAACGGTTC ACCAGTGTTTAGTTTTATATTGAGGTGCTCAGGTTGGAATAAAGTGGTATAAAAAGCAAA AAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_004162 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004162.3, NP_004153.2 |
| RefSeq Size | 2352 bp |
| RefSeq ORF | 648 bp |
| Locus ID | 5868 |
| UniProt ID | P20339 |
| Domains | ras, RAN, RAS, RHO, RAB |
| Protein Families | Druggable Genome |
| Protein Pathways | Amyotrophic lateral sclerosis (ALS), Endocytosis |
| Gene Summary | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus
,null,
Science Advances
,PubMed ID 34985962
[RAB5A]
|
|
Toll-like Receptor 3 (TLR3) Signaling Requires TLR4 Interactor with Leucine-rich Repeats (TRIL)
,null,
The Journal of Biological Chemistry
,PubMed ID 21911501
[RAB5A]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203873 | RAB5A (Myc-DDK-tagged)-Human RAB5A, member RAS oncogene family (RAB5A) |
CNY 2,400.00 |
|
| RC203873L1 | Lenti ORF clone of Human RAB5A, member RAS oncogene family (RAB5A), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC203873L2 | Lenti ORF clone of Human RAB5A, member RAS oncogene family (RAB5A), mGFP tagged |
CNY 5,890.00 |
|
| RC203873L3 | Lenti ORF clone of Human RAB5A, member RAS oncogene family (RAB5A), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC203873L4 | Lenti ORF clone of Human RAB5A, member RAS oncogene family (RAB5A), mGFP tagged |
CNY 4,800.00 |
|
| RG203873 | RAB5A (tGFP-tagged) - Human RAB5A, member RAS oncogene family (RAB5A) |
CNY 4,000.00 |
|
| SC117557 | RAB5A (untagged)-Human RAB5A, member RAS oncogene family (RAB5A) |
CNY 3,600.00 |
