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SLFN11 (NM_001104588) Human Untagged Clone
CAT＃: SC317146
SLFN11 (untagged)-Human schlafen family member 11 (SLFN11), transcript variant 2
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SLFN8/9 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001104588, the custom clone sequence may differ by one or more nucleotides
ATGGAGGCAAATCAGTGCCCCCTGGTTGTGGAACCATCTTACCCAGACCTGGTCATCAAT GTAGGAGAAGTGACTCTTGGAGAAGAAAACAGAAAAAAGCTGCAGAAAATTCAGAGAGAC CAAGAGAAGGAGAGAGTTATGCGGGCTGCATGTGCTTTATTAAACTCAGGAGGAGGAGTG ATTCGAATGGCCAAGAAGGTTGAGCATCCCGTGGAGATGGGACTGGATTTAGAACAGTCT TTGAGAGAGCTTATTCAGTCTTCAGATCTGCAGGCTTTCTTTGAGACCAAGCAACAAGGA AGGTGTTTTTACATTTTTGTTAAATCTTGGAGCAGTGGCCCTTTCCCTGAAGATCGCTCT GTCAAGCCCCGCCTTTGCAGCCTCAGTTCTTCATTATACCGTAGATCTGAGACCTCTGTG CGTTCCATGGACTCAAGAGAGGCATTCTGTTTCCTGAAGACCAAAAGGAAGCCAAAAATC TTGGAAGAAGGACCTTTTCACAAAATTCACAAGGGTGTATACCAAGAGCTCCCTAACTCG GATCCTGCTGACCCAAACTCGGATCCTGCTGACCTAATTTTCCAAAAAGACTATCTTGAA TATGGTGAAATCCTGCCTTTTCCTGAGTCTCAGTTAGTAGAGTTTAAACAGTTCTCTACA AAACACTTCCAAGAATATGTAAAAAGGACAATTCCAGAATACGTCCCTGCATTTGCAAAC ACTGGAGGAGGCTATCTTTTTATTGGAGTGGATGATAAGAGTAGGGAAGTCCTGGGATGT GCAAAAGAAAATGTTGACCCTGACTCTTTGAGAAGGAAAATAGAACAAGCCATATACAAA CTACCTTGTGTTCATTTTTGCCAACCCCAACGCCCGATAACCTTCACACTCAAAATTGTG AATGTGTTAAAAAGGGGAGAGCTCTATGGCTATGCTTGCATGATCAGAGTAAATCCCTTC TGCTGTGCAGTGTTCTCAGAAGCTCCCAATTCATGGATAGTGGAGGACAAGTACGTCTGC AGCCTGACAACCGAGAAATGGGTAGGCATGATGACAGACACAGATCCAGATCTTCTACAG TTGTCTGAAGATTTTGAATGTCAGCTGAGTCTATCTAGTGGGCCTCCCCTTAGCAGACCA GTGTACTCCAAGAAAGGCCTGGAACATAAAAAGGAACTCCAGCAACTTTTATTTTCAGTC CCACCAGGATATTTGCGATATACTCCAGAGTCACTCTGGAGGGACCTGATCTCAGAGCAC AGAGGACTAGAGGAGTTAATAAATAAGCAAATGCAACCTTTCTTTCGGGGAATTTTGATC TTCTCTAGAAGTTGGGCTGTGGACCTGAACTTGCAGGAGAAGCCAGGAGTCATCTGTGAT GCTCTGCTGATAGCACAGAACAGCACCCCCATTCTCTACACCATTCTCAGGGAGCAAGAT GCAGAGGGCCAGGACTACTGCACTCGCACCGCCTTTACTTTGAAGCAGAAGCTAGTGAAC ATGGGGGGCTACACCGGGAAGGTGTGTGTCAGGGCCAAGGTCCTCTGCCTGAGTCCTGAG AGCAGCGCAGAGGCCTTGGAGGCTGCAGTGTCTCCGATGGATTACCCTGCGTCCTATAGC CTTGCAGGCACCCAGCACATGGAAGCCCTGCTGCAGTCCCTCGTGATTGTCTTACTCGGC TTCAGGTCTCTCTTGAGTGACCAGCTCGGCTGTGAGGTTTTAAATCTGCTCACAGCCCAG CAGTATGAGATATTCTCCAGAAGCCTCCGCAAGAACAGAGAGTTGTTTGTCCACGGCTTA CCTGGCTCAGGGAAGACCATCATGGCCATGAAGATCATGGAGAAGATCAGGAATGTGTTT CACTGTGAGGCACACAGAATTCTCTACGTTTGTGAAAACCAGCCTCTGAGGAACTTTATC AGTGATAGAAATATCTGCCGAGCAGAGACCCGGAAAACTTTCCTAAGAGAAAACTTTGAA CACATTCAACACATCGTCATTGACGAAGCTCAGAATTTCCGTACTGAAGATGGGGACTGG TATGGGAAGGCAAAAAGCATCACTCGGAGAGCAAAGGGTGGCCCAGGAATTCTCTGGATC TTTCTGGATTACTTTCAGACCAGCCACTTGGATTGCAGTGGCCTCCCTCCTCTCTCAGAC CAATATCCAAGAGAAGAGCTCACCAGAATAGTTCGCAATGCAGATCCAATAGCCAAGTAC TTACAAAAAGAAATGCAAGTAATTAGAAGTAATCCTTCATTTAACATCCCCACTGGGTGC CTCGAGGTATTTCCTGAAGCCGAATGGTCCCAGGGTGTTCAGGGAACCTTACGAATTAAG AAATACTTGACTGTGGAGCAAATAATGACCTGTGTGGCAGACACGTGCAGGCGCTTCTTT GATAGGGGCTATTCTCCAAAGGATGTTGCTGTGCTTGTCAGCACCGCAAAAGAAGTGGAG CACTATAAGTATGAGCTCTTGAAAGCAATGAGGAAGAAAAGGGTGGTGCAGCTCAGTGAT GCATGTGATATGTTGGGTGATCACATTGTGTTGGACAGTGTTCGGCGATTCTCAGGCCTG GAAAGGAGCATAGTGTTTGGGATCCATCCAAGGACAGCTGACCCAGCTATCTTACCCAAT GTTCTGATCTGTCTGGCTTCCAGGGCAAAACAACACCTGTATATTTTTCCGTGGGGTGGC CAT |
| Restriction Sites | Please inquire |
| ACCN | NM_001104588 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001104588.1, NP_001098058.1 |
| RefSeq Size | 5210 bp |
| RefSeq ORF | 2706 bp |
| Locus ID | 91607 |
| UniProt ID | Q7Z7L1 |
| Gene Summary | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC226248 | SLFN11 (Myc-DDK-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 2 |
CNY 3,990.00 |
|
| RC226248L3 | Lenti-ORF clone of SLFN11 (Myc-DDK-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 2 |
CNY 5,890.00 |
|
| RC226248L4 | Lenti-ORF clone of SLFN11 (mGFP-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 2 |
CNY 5,890.00 |
|
| RG226248 | SLFN11 (tGFP-tagged) - Human schlafen family member 11 (SLFN11), transcript variant 2 |
CNY 8,856.00 |
