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SLFN11 (NM_001104587) Human Untagged Clone
CAT＃: SC317145
SLFN11 (untagged)-Human schlafen family member 11 (SLFN11), transcript variant 1
CNY 10,568.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SLFN8/9 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC317145 representing NM_001104587.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGAGGCAAATCAGTGCCCCCTGGTTGTGGAACCATCTTACCCAGACCTGGTCATCAATGTAGGAGAA GTGACTCTTGGAGAAGAAAACAGAAAAAAGCTGCAGAAAATTCAGAGAGACCAAGAGAAGGAGAGAGTT ATGCGGGCTGCATGTGCTTTATTAAACTCAGGAGGAGGAGTGATTCGAATGGCCAAGAAGGTTGAGCAT CCCGTGGAGATGGGACTGGATTTAGAACAGTCTTTGAGAGAGCTTATTCAGTCTTCAGATCTGCAGGCT TTCTTTGAGACCAAGCAACAAGGAAGGTGTTTTTACATTTTTGTTAAATCTTGGAGCAGTGGCCCTTTC CCTGAAGATCGCTCTGTCAAGCCCCGCCTTTGCAGCCTCAGTTCTTCATTATACCGTAGATCTGAGACC TCTGTGCGTTCCATGGACTCAAGAGAGGCATTCTGTTTCCTGAAGACCAAAAGGAAGCCAAAAATCTTG GAAGAAGGACCTTTTCACAAAATTCACAAGGGTGTATACCAAGAGCTCCCTAACTCGGATCCTGCTGAC CCAAACTCGGATCCTGCTGACCTAATTTTCCAAAAAGACTATCTTGAATATGGTGAAATCCTGCCTTTT CCTGAGTCTCAGTTAGTAGAGTTTAAACAGTTCTCTACAAAACACTTCCAAGAATATGTAAAAAGGACA ATTCCAGAATACGTCCCTGCATTTGCAAACACTGGAGGAGGCTATCTTTTTATTGGAGTGGATGATAAG AGTAGGGAAGTCCTGGGATGTGCAAAAGAAAATGTTGACCCTGACTCTTTGAGAAGGAAAATAGAACAA GCCATATACAAACTACCTTGTGTTCATTTTTGCCAACCCCAACGCCCGATAACCTTCACACTCAAAATT GTGAATGTGTTAAAAAGGGGAGAGCTCTATGGCTATGCTTGCATGATCAGAGTAAATCCCTTCTGCTGT GCAGTGTTCTCAGAAGCTCCCAATTCATGGATAGTGGAGGACAAGTACGTCTGCAGCCTGACAACCGAG AAATGGGTAGGCATGATGACAGACACAGATCCAGATCTTCTACAGTTGTCTGAAGATTTTGAATGTCAG CTGAGTCTATCTAGTGGGCCTCCCCTTAGCAGACCAGTGTACTCCAAGAAAGGCCTGGAACATAAAAAG GAACTCCAGCAACTTTTATTTTCAGTCCCACCAGGATATTTGCGATATACTCCAGAGTCACTCTGGAGG GACCTGATCTCAGAGCACAGAGGACTAGAGGAGTTAATAAATAAGCAAATGCAACCTTTCTTTCGGGGA ATTTTGATCTTCTCTAGAAGTTGGGCTGTGGACCTGAACTTGCAGGAGAAGCCAGGAGTCATCTGTGAT GCTCTGCTGATAGCACAGAACAGCACCCCCATTCTCTACACCATTCTCAGGGAGCAAGATGCAGAGGGC CAGGACTACTGCACTCGCACCGCCTTTACTTTGAAGCAGAAGCTAGTGAACATGGGGGGCTACACCGGG AAGGTGTGTGTCAGGGCCAAGGTCCTCTGCCTGAGTCCTGAGAGCAGCGCAGAGGCCTTGGAGGCTGCA GTGTCTCCGATGGATTACCCTGCGTCCTATAGCCTTGCAGGCACCCAGCACATGGAAGCCCTGCTGCAG TCCCTCGTGATTGTCTTACTCGGCTTCAGGTCTCTCTTGAGTGACCAGCTCGGCTGTGAGGTTTTAAAT CTGCTCACAGCCCAGCAGTATGAGATATTCTCCAGAAGCCTCCGCAAGAACAGAGAGTTGTTTGTCCAC GGCTTACCTGGCTCAGGGAAGACCATCATGGCCATGAAGATCATGGAGAAGATCAGGAATGTGTTTCAC TGTGAGGCACACAGAATTCTCTACGTTTGTGAAAACCAGCCTCTGAGGAACTTTATCAGTGATAGAAAT ATCTGCCGAGCAGAGACCCGGAAAACTTTCCTAAGAGAAAACTTTGAACACATTCAACACATCGTCATT GACGAAGCTCAGAATTTCCGTACTGAAGATGGGGACTGGTATGGGAAGGCAAAAAGCATCACTCGGAGA GCAAAGGGTGGCCCAGGAATTCTCTGGATCTTTCTGGATTACTTTCAGACCAGCCACTTGGATTGCAGT GGCCTCCCTCCTCTCTCAGACCAATATCCAAGAGAAGAGCTCACCAGAATAGTTCGCAATGCAGATCCA ATAGCCAAGTACTTACAAAAAGAAATGCAAGTAATTAGAAGTAATCCTTCATTTAACATCCCCACTGGG TGCCTCGAGGTATTTCCTGAAGCCGAATGGTCCCAGGGTGTTCAGGGAACCTTACGAATTAAGAAATAC TTGACTGTGGAGCAAATAATGACCTGTGTGGCAGACACGTGCAGGCGCTTCTTTGATAGGGGCTATTCT CCAAAGGATGTTGCTGTGCTTGTCAGCACCGCAAAAGAAGTGGAGCACTATAAGTATGAGCTCTTGAAA GCAATGAGGAAGAAAAGGGTGGTGCAGCTCAGTGATGCATGTGATATGTTGGGTGATCACATTGTGTTG GACAGTGTTCGGCGATTCTCAGGCCTGGAAAGGAGCATAGTGTTTGGGATCCATCCAAGGACAGCTGAC CCAGCTATCTTACCCAATGTTCTGATCTGTCTGGCTTCCAGGGCAAAACAACACCTGTATATTTTTCCG TGGGGTGGCCATTAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001104587 |
| Insert Size | 2706 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001104587.1 |
| RefSeq Size | 5292 bp |
| RefSeq ORF | 2706 bp |
| Locus ID | 91607 |
| UniProt ID | Q7Z7L1 |
| MW | 102.8 kDa |
| Gene Summary | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript. All variants (1-5) encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC226247 | SLFN11 (Myc-DDK-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 1 |
CNY 9,896.00 |
|
| RC226247L1 | Lenti-ORF clone of SLFN11 (Myc-DDK-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 1 |
CNY 12,296.00 |
|
| RC226247L2 | Lenti-ORF clone of SLFN11 (mGFP-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 1 |
CNY 5,890.00 |
|
| RC226247L3 | Lenti-ORF clone of SLFN11 (Myc-DDK-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 1 |
CNY 12,296.00 |
|
| RC226247L4 | Lenti-ORF clone of SLFN11 (mGFP-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 1 |
CNY 12,296.00 |
|
| RG226247 | SLFN11 (tGFP-tagged) - Human schlafen family member 11 (SLFN11), transcript variant 1 |
CNY 11,496.00 |
