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Band 3 (SLC4A1) (NM_000342) Human Untagged Clone
CAT＃: SC314903
SLC4A1 (untagged)-Human solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (SLC4A1)
CNY 6,680.00
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AE1; BND3; CD233; CHC; DI; EMPB3; EPB3; FR; RTA1A; SAO; SPH4; SW; WD; WD1; WR |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000342 edited
ATGGAGGAGCTGCAGGATGATTATGAAGACATGATGGAGGAGAATCTGGAGCAGGAGGAA TATGAAGACCCAGACATCCCCGAGTCCCAGATGGAGGAGCCGGCAGCTCACGACACCGAG GCAACAGCCACAGACTACCACACCACATCACACCCGGGTACCCACAAGGTCTATGTGGAG CTGCAGGAGCTGGTGATGGACGAAAAGAACCAGGAGCTGAGATGGATGGAGGCGGCGCGC TGGGTGCAACTGGAGGAGAACCTGGGGGAGAATGGGGCCTGGGGCCGCCCGCACCTCTCT CACCTCACCTTCTGGAGCCTCCTAGAGCTGCGTAGAGTCTTCACCAAGGGTACTGTCCTC CTAGACCTGCAAGAGACCTCCCTGGCTGGAGTGGCCAACCAACTGCTAGACAGGTTTATC TTTGAAGACCAGATCCGGCCTCAGGACCGAGAGGAGCTGCTCCGGGCCCTGCTGCTTAAA CACAGCCACGCTGGAGAGCTGGAGGCCCTGGGGGGTGTGAAGCCTGCAGTCCTGACACGC TCTGGGGATCCTTCACAGCCTCTGCTCCCCCAACACTCCTCACTGGAGACACAGCTCTTC TGTGAGCAGGGAGATGGGGGCACAGAAGGGCACTCACCATCTGGAATTCTGGAAAAGATT CCCCCGGATTCAGAGGCCACGTTGGTGCTAGTGGGCCGCGCCGACTTCCTGGAGCAGCCG GTGCTGGGCTTCGTGAGGCTGCAGGAGGCAGCGGAGCTGGAGGCGGTGGAGCTGCCGGTG CCTATACGCTTCCTCTTTGTGTTGCTGGGACCTGAGGCCCCCCACATCGATTACACCCAG CTTGGCCGGGCTGCTGCCACCCTCATGTCAGAGAGGGTGTTCCGCATAGATGCCTACATG GCTCAGAGCCGAGGGGAGCTGCTGCACTCCCTAGAGGGCTTCCTGGACTGCAGCCTAGTG CTGCCTCCCACCGATGCCCCCTCCGAGCAGGCACTGCTCAGTCTGGTGCCTGTGCAGAGG GAGCTACTTCGAAGGCGCTATCAGTCCAGCCCTGCCAAGCCAGACTCCAGCTTCTACAAG GGCCTAGACTTAAATGGGGGCCCAGATGACCCTCTGCAGCAGACAGGCCAGCTCTTCGGG GGCCTGGTGCGTGATATCCGGCGCCGCTACCCCTATTACCTGAGTGACATCACAGATGCA TTCAGCCCCCAGGTCCTGGCTGCCGTCATCTTCATCTACTTTGCTGCACTGTCACCCGCC ATCACCTTCGGCGGCCTCCTGGGAGAAAAGACCCGGAACCAGATGGGAGTGTCGGAGCTG CTGATCTCCACTGCAGTGCAGGGCATTCTCTTCGCCCTGCTGGGGGCTCAGCCCCTGCTT GTGGTCGGCTTCTCAGGACCCCTGCTGGTGTTTGAGGAAGCCTTCTTCTCGTTCTGCGAG ACCAACGGTCTAGAGTACATCGTGGGCCGCGTGTGGATCGGCTTCTGGCTCATCCTGCTG GTGGTGTTGGTGGTGGCCTTCGAGGGTAGCTTCCTGGTCCGCTTCATCTCCCGCTATACC CAGGAGATCTTCTCCTTCCTCATTTCCCTCATCTTCATCTATGAGACTTTCTCCAAGCTG ATCAAGATCTTCCAGGACCACCCACTACAGAAGACTTATAACTACAACGTGTTGATGGTG CCCAAACCTCAGGGCCCCCTGCCCAACACAGCCCTCCTCTCCCTTGTGCTCATGGCCGGT ACCTTCTTCTTTGCCATGATGCTGCGCAAGTTCAAGAACAGCTCCTATTTCCCTGGCAAG CTGCGTCGGGTCATCGGGGACTTCGGGGTCCCCATCTCCATCCTGATCATGGTCCTGGTG GATTTCTTCATTCAGGATACCTACACCCAGAAACTCTCGGTGCCTGATGGCTTCAAGGTG TCCAACTCCTCAGCCCGGGGCTGGGTCATCCACCCACTGGGCTTGCGTTCCGAGTTTCCC ATCTGGATGATGTTTGCCTCCGCCCTGCCTGCTCTGCTGGTCTTCATCCTCATATTCCTG GAGTCTCAGATCACCACGCTGATTGTCAGCAAACCTGAGCGCAAGATGGTCAAGGGCTCC GGCTTCCACCTGGACCTGCTGCTGGTAGTAGGCATGGGTGGGGTGGCCGCCCTCTTTGGG ATGCCCTGGCTCAGTGCCACCACCGTGCGTTCCGTCACCCATGCCAACGCCCTCACTGTC ATGGGCAAAGCCAGCACCCCAGGGGCTGCAGCCCAGATCCAGGAGGTCAAAGAGCAGCGG ATCAGTGGACTCCTGGTCGCTGTGCTTGTGGGCCTGTCCATCCTCATGGAGCCCATCCTG TCCCGCATCCCCCTGGCTGTACTGTTTGGCATCTTCCTCTACATGGGGGTCACGTCGCTC AGCGGCATCCAGCTCTTTGACCGCATCTTGCTTCTGTTCAAGCCACCCAAGTATCACCCA GATGTGCCCTACGTCAAGCGGGTGAAGACCTGGCGCATGCACTTATTCACGGGCATCCAG ATCATCTGCCTGGCAGTGCTGTGGGTGGTGAAGTCCACGCCGGCCTCCCTGGCCCTGCCC TTCGTCCTCATCCTCACTGTGCCGCTGCGGCGCGTCCTGCTGCCGCTCATCTTCAGGAAC GTGGAGCTTCAGTGTCTGGATGCTGATGATGCCAAGGCAACCTTTGATGAGGAGGAAGGT CGGGATGAATACGACGAAGTGGCCATGCCTGTGTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_000342 |
| Insert Size | 2700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000342.1, NP_000333.1 |
| RefSeq Size | 3637 bp |
| RefSeq ORF | 2736 bp |
| Locus ID | 6521 |
| UniProt ID | P02730 |
| Domains | HCO3_cotransp |
| Protein Families | Druggable Genome, Transmembrane |
| Gene Summary | The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC218312 | SLC4A1 (Myc-DDK-tagged)-Human solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (SLC4A1) |
CNY 6,672.00 |
|
| RC218312L1 | Lenti ORF clone of Human solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (SLC4A1), Myc-DDK-tagged |
CNY 9,072.00 |
|
| RC218312L2 | Lenti ORF clone of Human solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (SLC4A1), mGFP tagged |
CNY 9,030.00 |
|
| RC218312L3 | Lenti ORF clone of Human solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (SLC4A1), Myc-DDK-tagged |
CNY 9,030.00 |
|
| RC218312L4 | Lenti ORF clone of Human solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (SLC4A1), mGFP tagged |
CNY 9,030.00 |
|
| RG218312 | SLC4A1 (tGFP-tagged) - Human solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (SLC4A1) |
CNY 7,890.00 |
