EMP2 (AK096403) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	XMP
Vector	pCMV6 series
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AK096403, the custom clone sequence may differ by one or more nucleotides ATGGTCATCCTTAACCTGCGTGCCAGATTTAGACTCGTCTTTAGGCAAAACCTACAGCGC CCCCCCCCTCACCCCAGACCTACAGAATCAGAGTCTTCAAGGGATGGGGCCAGGGAATCT GCATTTCTAACGCGCTCCCTGGGCAACGCTTCAGATGCGTTGAAGTTGGGGACCACGGTG CCTGGGCCAGGTCAGCAGAGCTGCCTCGTAAATGCTGGGGTATCGTCATGTGGAGATGGG GAGGTGAATGCAACCCCCACAGCAGGCCAAAACCTTGGCCTCCATCGCCACAGCTGTCTA CATCTAGGGCCCCAAAACTCCATTCCTGAGCCATGTGAACTCATAGACACCTTCAGGGTG TGGGGTACAGCCTCCTTCCCATCTTATCCCAGAAGGCCTCTCCCTTCTTGTCCAGCCCTT CATGCTACACCTGGCTGGCCTCTCACCCCTATTTCTAGAGCCTCAGAGGACCCATCCACC ATTCATTCATTCATTCATTCATTCATTCATTCATTCATTCATTCATCAACA
Restriction Sites	Please inquire
ACCN	AK096403
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	AK096403.1
RefSeq Size	2242 bp
RefSeq ORF	2242 bp
Locus ID	2013
Protein Families	Transmembrane
Gene Summary	This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.