FAM89B (BC023991) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	family with sequence similarity 89, member B; mammary turmor virus receptor homolog 1; MTVR1
Vector	pCMV6 series
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for BC023991, the custom clone sequence may differ by one or more nucleotides ATGAACGGGCTGCCCTCGGCAGAGGCGCCGGGCGGGGCGGGCTGCGCTTTGGCCGGGCTC CCACCGCTGCCGCGCGGCCTCAGCGGCCTCCTTAATGCGAGCGGGGGCTCGTGGCGGGAG CTGGAGCGCGTCTACAGCCAGCGCAGCCGCGTCGTCCTGTCAACCTCGACTCAGCGCTGG CCGCGCTGCGCAAGGAGATGTTGTCTGCAGGTGGGGCTGCGGCAGTTGGACATGTCCTTG TTGTGCCAGCTGTGGGGCCTGTACGAGTCAATCCAGGACTACAAACACCTGTGCCAAGAC CTGAGCTTCTGCCAGGACCTGTCATCCTCCCTCCATTCGGACAGCTCCTACCCACCGGAT GCGGGCCTGTCTGACGACGAGGAGCCTCCCGATGCCAGCCTGCCTCCTGACCCGCCACCC CTTACTGTGCCCCAGACGCACAATGCCCGTGACCAGTGGCTGCAGGATGCCTTCCACATC AGCCTC
Restriction Sites	Please inquire
ACCN	BC023991
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC023991.2, AAH23991.1
RefSeq Size	1900 bp
RefSeq ORF	489 bp
Locus ID	23625
Protein Families	Druggable Genome
Gene Summary	Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.[UniProtKB/Swiss-Prot Function]

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