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HSF4 (NM_001040667) Human Untagged Clone
CAT＃: SC311161
HSF4 (untagged)-Human heat shock transcription factor 4 (HSF4), transcript variant 2
CNY 3,656.00
CNY 7,890.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CTM; CTRCT5 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001040667 edited
GCCCGCAGCGGCCGGGCCCGAGCGCAGAGCCGGGCCGAGACTGCACCATGCAGGAAGCGC CAGCTGCGCTGCCCACGGAGCCAGGCCCCAGCCCCGTGCCTGCCTTCCTCGGCAAGCTAT GGGCGCTGGTGGGGGACCCAGGCACAGACCACCTGATCCGCTGGAGCCCGAGCGGGACCA GTTTCCTCGTAAGCGACCAGAGCCGTTTCGCCAAGGAAGTGCTGCCCCAGTATTTCAAGC ATAGCAACATGGCGAGCTTCGTGCGCCAACTCAACATGTACGGTTTTCGGAAGGTGGTGA GCATCGAGCAGGGCGGCCTGCTTAGGCCGGAGCGCGACCACGTCGAGTTCCAGCACCCGA GCTTCGTGCGCGGCCGCGAGCAGCTACTGGAGCGCGTGCGGCGCAAGGTGCCCGCGCTGC GCGGCGACGACGGCCGCTGGCGCCCGGAGGACCTGGGTCGACTACTGGGCGAGGTGCAGG CTTTGCGGGGAGTGCAGGAGAGCACCGAGGCGCGGCTGCGGGAGCTCAGGCAGCAGAACG AGATCTTGTGGCGGGAGGTGGTGACACTTCGGCAGAGCCACGGTCAGCAGCACCGGGTCA TTGGCAAGCTGATCCAGTGTCTCTTTGGGCCACTTCAGGCGGGGCCGAGCAATGCAGGAG GCAAGAGAAAGCTGTCCCTGATGCTGGATGAGGGGAGCTCATGCCCAACACCTGCCAAGT TCAACACCTGCCCTCTACCTGGTGCCCTTCTGCAGGACCCCTACTTCATCCAGTCGCCTC TCCCAGAGACAAATTTGGGCCTTAGCCCTCACAGGGCCAGGGGCCCCATCATCTCTGACA TCCCAGAAGACTCTCCATCCCCTGAGGGGACCAGGCTTTCTCCCTCCAGTGATGGCAGGA GGGAGAAGGGCCTGGCACTGCTCAAAGAAGAGCCGGCCAGTCCAGGGGGGGATGGCGAGG CCGGGCTGGCCCTGGCCCCAAACGAGTGTGACTTCTGCGTGACAGCCCCCCCGCCACTGC CTGTGGCTGTGGTGCAGGCCATCCTGGAAGGGAAAGGGAGCTTCAGCCCCGAGGGGCCCA GGAATGCCCAACAGCCTGAACCAGGGGATCCCAGGGAGATACCTGACAGGGGGCCTCTGG GCCTGGAAAGCGGGGACAGGAGCCCAGAGAGTCTGCTGCCTCCGATGCTGCTTCAGCCCC CTCAAGAAAGTGTGGAACCTGCAGGGCCTCTAGATGTGCTGGGCCCCAGTCTCCAAGGGC GAGAATGGACCCTGATGGACTTGGACATGGAGCTGTCCTTGATGCAGCCCTTGGTTCCAG AGCGGGGTGAGCCTGAGCTGGCGGTCAAGGTGTTAAATTCTCCAAGCCCAGGGAAGGACC CCACGCTCGGGGCCCCACTCCTGCTGGATGTCCAGGCGGCCTTGGGAGGCCCAGCCCTGG GCCTGCCTGGGGCTTTAACCATTTATAGCACTCCTGAGAGCCGGACTGCCTCCTACTTGG GCCCGGAAGCCAGTCCCTCCCCCTAAGACCCCGCGCCTCTGAAGGGGCTTGGAACCAGTC CGCCGCTGCACATCCTTCTTGGCTTCCTGGCGCCCCCTATCGGGGGTGAGCGAAGCCCCC ACTACTAAATGGCCTCTCTCCACTACCCCGACTATCCCTGCACATAAACTCCG >OriGene 5' read for NM_001040667 unedited
NGGGTTAGATATTTGTATACGACTCACTATAGGCGGCCGCGCAATTCGGCACGAGGGCCC GCAGCGGCCGGGCCCGAGCGCAGAGCCGGGCCGAGACTGCACCATGCAGGAAGCGCCAGC TGCGCTGCCCACGGAGCCAGGCCCCAGCCCCGTGCCTGCCTTCCTCGGCAAGCTATGGGC GCTGGTGGGGGACCCAGGCACAGACCACCTGATCCGCTGGAGCCCGAGCGGGACCAGTTT CCTCGTAAGCGACCAGAGCCGTTTCGCCAAGGAAGTGCTGCCCCAGTATTTCAAGCATAG CAACATGGCGAGCTTCGTGCGCCAACTCAACATGTACGGTTTTCGGAAGGTGGTGAGCAT CGAGCAGGGCGGCCTGCTTAGGCCGGAGCGCGACCACGTCGAGTTCCAGCACCCGAGCTT CGTGCGCGGCCGCGAGCAGCTACTGGAGCGCGTGCGGCGCAAGGTGCCCGCGCTGCGCGG CGACGACGGCCGCTGGCGCCCGGAGGACCTGGGTCGACTACTGGGCGAGGTGCAGGCTTT GCGGGGAGTGCAGGAGAGCACCGAGGCGCGGCTGCGGGAGCTCAGGCAGCAGAACGAGAT CTTGTGGCGGGAGGTGGTGACACTTCGGCAGAGCCACGGTCAGCAGCACCGGGTCATTGG CAAGCTGATCCAGTGTCTCTTTGGGCCACTTCAGGCGGNGCCGAGCAATGCAGGAGGCAA GAGAAAGCTGTCCCTGATGCTGGATGAGGGGAGCTCATGCCCAACACCTGCCAAGTTCAA CACCTGCCCTCTACCTGGTGCCCCTCTGCNAGACCCCTACTTCATCCAGTCGCCTCTCCC AGAGACAAATTTGGGGCCTAGCCCTCACAGGGCCCAGGGCCCCATCATCTCT >Forward primer walk for NM_001040667 unedited
ATCTTTGGGAGTCANAAGAGGGGCCCCTGGCCCTGTGAGGCTAAGGCCCAAATTGTCTCT GGGAGAGGCGACTGGATGAAGTAGGGGTCCTGCAGAAGGGCACCAGGTAGAGGGCAGGTG TTGAACTTGGCAGGTGTTGGGCATGAGCTCCCCTCATCCAGCATCAGGGACAGCTTTCTC TTGCCTCCTGCATTGCTCGGCCCCGCCTGAAGTGGCCCAAAGAGACACTGGATCAGCTTG CCAATGACCCGGTGCTGCTGACCGTGGCTCTGCCGAAGTGTCACCACCTCCCGCCACAAG ATCTCGTTCTGCTGCCTGAGCTCCCGCAGCCGCGCCTCGGTGCTCTCCTGCACTCCCCGC AAAGCCTGCACCTCGCCCAGTAGTCGACCCAGGTCCTCCGGGCGCCAGCGGCCGTCGTCG CCGCGCAGCGCGGGCACCTTGCGCCGCACGCGCTCCAGTAGCTGCTCGCGGCCGCGCACG AAGCTCGGGTGCTGGAACTCGACGTGGTCGCGCTCCGGCCTAAGCAGGCCGCCCTGCTCG ATGCTCACCACCTTCCGAAAACCGTACATGTTGAGTTGGCGCACGAAGCTCGCCATGTTG CTATGCTTGAAATACTGGGGCAGCACTTCCTTGGCGAAACGGCTCTGGTCGCTTACGAGG AAACTGGTCCCGCTNCGGCTCCAGCGGATCAGGTGGTCTGTGCCTGGGTCCCCCACCAGC GCCCATAGCTTTGCGAGGAAGGCANGCACNGNGCTGGGGCCTGGCTCCGTGGGCAGCGCA GCTGGCGCTTCCTGCATGGTGCAGTCTCGGGCCCGCTCTGCGCTCGGGCCCCGCCGCTGC GGGCCCTCG |
| Restriction Sites | Please inquire |
| ACCN | NM_001040667 |
| Insert Size | 1700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | There is 1 nucleotide difference between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 1 amino acids. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001040667.1, NP_001035757.1 |
| RefSeq Size | 2535 bp |
| RefSeq ORF | 1479 bp |
| Locus ID | 3299 |
| UniProt ID | Q9ULV5 |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1, resulting in a longer protein (isoform b). This variant, alternatively referred to as HSF4b, functions as a transcriptional activator of the constitutive expression of heat shock genes. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Autosomal recessive congenital cataracts linked to HSF4 in a consanguineous Pakistani family
,Jiao, X;Khan, SY;Kaul, H;Butt, T;Naeem, MA;Riazuddin, S;Hejtmancik, JF;Riazuddin, SA;,
PLoS ONE
,PubMed ID 31815953
[HSF4]
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|
Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation
,He, S;Limi, S;McGreal, RS;Xie, Q;Brennan, LA;Kantorow, WL;Kokavec, J;Majumdar, R;Hou, H;Edelmann, W;Liu, W;Ashery-Padan, R;Zavadil, J;Kantorow, M;Skoultchi, AI;Stopka, T;Cvekl, A;,
Development
,PubMed ID 27246713
[HSF4]
|
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Functional Analysis of HSF4 Mutations Found in Patients With Autosomal Recessive Congenital Cataracts
,Merath, K;Ronchetti, A;Sidjanin, DJ;,
Invest Ophthalmol Vis Sci. 2013 Oct 11;54(10):6646-54
,PubMed ID 24045990
[HSF4]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC219247 | HSF4 (Myc-DDK-tagged)-Human heat shock transcription factor 4 (HSF4), transcript variant 2 |
CNY 3,656.00 |
|
| RC219247L1 | Lenti ORF clone of Human heat shock transcription factor 4 (HSF4), transcript variant 2, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC219247L2 | Lenti ORF clone of Human heat shock transcription factor 4 (HSF4), transcript variant 2, mGFP tagged |
CNY 6,180.00 |
|
| RC219247L3 | Lenti ORF clone of Human heat shock transcription factor 4 (HSF4), transcript variant 2, Myc-DDK-tagged |
CNY 6,180.00 |
|
| RC219247L4 | Lenti ORF clone of Human heat shock transcription factor 4 (HSF4), transcript variant 2, mGFP tagged |
CNY 6,180.00 |
|
| RG219247 | HSF4 (tGFP-tagged) - Human heat shock transcription factor 4 (HSF4), transcript variant 2 |
CNY 5,256.00 |
