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NADPH oxidase 4 (NOX4) (NM_016931) Human Untagged Clone
CAT＃: SC310253
NOX4 (untagged)-Human NADPH oxidase 4 (NOX4), transcript variant 1
CNY 6,464.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | KOX; KOX-1; RENOX |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_016931 edited
CCGCTGCCCCGGCCGCCGCCCGCTCCTTCTCGGTCCGGCGGGCACAGAGCGCAGCGCGGC GGGGCCGGCG GCATGGCTGTGTCCTGGAGGAGCTGGCTCGCCAACGAAGGGGTTAAACA CCTCTGCCTGTTCATCTGGCT CTCCATGAATGTCCTGCTTTTCTGGAAAACCTTCTTGC TGTATAACCAAGGGCCAGAGTATCACTACCTC CACCAGATGTTGGGGCTAGGATTGTGT CTAAGCAGAGCCTCAGCATCTGTTCTTAACCTCAACTGCAGCC TTATCCTTTTACCCAT GTGCCGAACACTCTTGGCTTACCTCCGAGGATCACAGAAGGTTCCAAGCAGGAG AACCA GGAGATTGTTGGATAAAAGCAGAACATTCCATATTACCTGTGGTGTTACTATCTGTATTT TCTCA GGCGTGCATGTGGCTGCCCATCTGGTGAATGCCCTCAACTTCTCAGTGAATTAC AGTGAAGACTTTGTTG AACTGAATGCAGCAAGATACCGAGATGAGGATCCTAGAAAACT TCTCTTCACAACTGTTCCTGGCCTGAC AGGGGTCTGCATGGTGGTGGTGCTATTCCTCA TGATCACAGCCTCTACATATGCAATAAGAGTTTCTAAC TATGATATCTTCTGGTATACT CATAACCTCTTCTTTGTCTTCTACATGCTGCTGACGTTGCATGTTTCAG GAGGGCTGCT GAAGTATCAAACTAATTTAGATACCCACCCTCCCGGCTGCATCAGTCTTAACCGAACCAG CTCTCAGAATATTTCCTTACCAGAGTATTTCTCAGAACATTTTCATGAACCTTTCCCTG AAGGATTTTCA AAACCGGCAGAGTTTACCCAGCACAAATTTGTGAAGATTTGTATGGAA GAGCCCAGATTCCAAGCTAATT TTCCACAGACTTGGCTTTGGATTTCTGGACCTTTGTG CCTGTACTGTGCCGAAAGACTTTACAGGTATAT CCGGAGCAATAAGCCAGTCACCATCA TTTCGGTCATAAGTCATCCCTCAGATGTCATGGAAATCCGAATG GTCAAAGAAAATTTT AAAGCAAGACCTGGTCAGTATATTACTCTACATTGTCCCAGTGTATCTGCATTAG AAAA TCATCCATTTACCCTCACAATGTGTCCAACTGAAACCAAAGCAACATTTGGGGTTCATCT TAAAAT AGTAGGAGACTGGACAGAACGATTTCGAGATTTACTACTGCCTCCATCTAGTC AAGACTCCGAAATTCTG CCCTTCATTCAATCTAGAAATTATCCCAAGCTGTATATTGAT GGTCCTTTTGGAAGTCCATTTGAGGAAT CACTGAACTATGAGGTCAGCCTCTGCGTGGC TGGAGGCATTGGAGTAACTCCATTTGCATCAATACTCAA CACCCTGTTGGATGACTGGA AACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGAGATATC CAGTCCTTC CGTTGGTTTGCAGATTTACTCTGTATGTTGCATAACAAGTTTTGGCAAGAGAACAGACCT G ACTATGTCAACATCCAGCTGTACCTCAGTCAAACAGATGGGATACAGAAGATAATTGG AGAAAAATATCA TGCACTGAATTCAAGACTGTTTATAGGACGTCCTCGGTGGAAACTTT TGTTTGATGAAATAGCAAAATAT AACAGAGGAAAAACAGTTGGTGTTTTCTGTTGTGGA CCCAATTCACTATCCAAGACTCTTCATAAACTGA GTAACCAGAACAACTCATATGGGAC AAGATTTGAATACAATAAAGAGTCTTTCAGCTGAAAACTTTTGCC ATGAAGCAGGACTC TAAAGAAGGAATGAGTGCAATTTCTAAGACTTTGAAACTCAGCGGAATCAATCAGC TGT GTTATGCCAAAGAATAGTAAGGTTTTCTTATTTATGATTATTTAAAATGGAAATGTGAGA ATGTGGC AAGATGACCGTCACATTACATGTTTAATCTGGAAACCAAAGAGACCCTGAAG AATATTTGATGTGATGAT TCACTTTTCAGTTCTCAAATTAAAAGAAAACTGTTAGATGC AAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAA >OriGene 5' read for NM_016931 unedited
NNGGGTTCAAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCAATCTGGTACCGGT CCGGAATTCCCGGGATCCGCTGCCCCGGCCGCCGCCCGCTCCTTCTCGGTCCGGCGGGCA CAGAGCGCAGCGCGGCGGGGCCGGCGGCATGGCTGTGTCCTGGAGGAGCTGGCTCGCCAA CGAAGGGGTTAAACACCTCTGCCTGTTCATCTGGCTCTCCATGAATGTCCTGCTTTTCTG GAAAACCTTCTTGCTGTATAACCAAGGGCCAGAGTATCACTACCTCCACCAGATGTTGGG GCTAGGATTGTGTCTAAGCAGAGCCTCAGCATCTGTTCTTAACCTCAACTGCAGCCTTAT CCTTTTACCCATGTGCCGAACACTCTTGGCTTACCTCCGAGGATCACAGAAGGTTCCAAG CAGGAGAACCAGGAGATTGTTGGATAAAAGCAGAACATTCCATATTACCTGTGGTGTTAC TATCTGTATTTTCTCAGGCGTGCATGTGGCTGCCCATCTGGTGAATGCCCTCAACTTCTC AGTGAATTACAGTGAAGACTTTGTTGAACTGAATGCAGCAAGATACCGAGATGAGGATCC TAGAAAACTTCTCTTCACAACTGTTCCTGGCCTGACAGGGGTCTGCATGGTGGTGGTGCT ATTCCTCATGATCACAGCCTCTACATATGCAATAAGAGTTTCTAACTATGATATCTTCTG GTATACTCATAACCTCTTCTTTGTCTTCTACATGCTGCTGACGTTGCATGTTTCANGAGG GCTGCTGAAGTATCAAACTAATTTAGATACCCACCCTCCCGGCTGCATCAGTCTTAACCG AACCAGCTCTCAGATATTTCCTTACCAGAGTATTTCTCAGAACATTTTCATGAACCTT >OriGene 3' read for NM_016931 unedited
AAGAGCAATGGGGAGGGTCAAGGGNNTAGCACCGGGTATGTTCAGAAAAGCTATGACCGC GGCCGCCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGCATCTAACAGTTNN TTCTTTTTAATTTGAGAACTGAAAAGTGAATCATCACATCAAATATTCTTCAGGGTCTCT TTGGTTTCCAGATTAAACATGTAATGTGACGGTCATCTTGCCACATTCTCACATTTCCAT TTTAAATAATCATAAATAAGAAAACCTTACTATTCTTTGGCATAACACAGCTGATTGATT CCGCTGAGTTTCAAAGTCTTAGAAATTGCACTCATTCCTTCTTTAGAGTCCTGCTTCATG GCAAAAGTTTTCAGCTGAAAGACTCTTTATTGTATTCAAATCTTGTCCCATATGAGTTGT TCTGGTTACTCAGTTTATGAAGAGTCTGNATAGTGAATTTGGGTCCACAACAGAAACACC AACTGGTTTTCCTCTGTTATATTTTGCTATTTCATCAAACAAAAGTTTCCACCCAGAACC TCCATTAACAGTCTTTGAATTCGTGCCTGAATTTTTTTTTTCCATTATCTTTTTGTTTCC CATCTGTTTTAACTGAAGGTACCACTGGGTTTTTGAACTTAATCCGGGTTTTGTTTTCTT TGGCAAACTTTGTTTTTGCCAACATCAACGAGTTAAATCCGGCAACACCACCGGGAGGGC TTGGGTTTTTTCTTGCTTTCCCCCAAAAAAAGTTTAATCTTTTTCAAACTTGGTTGGGGG TTTCCAGTTCACCCCCACGGGGTTGTTGAGTTTTTTGTGGCCCAAAGGGGGTTTTTTCCC CAAGGGCCCTCCCCCCCCCCCAGAGGTTG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_016931 |
| Insert Size | 2100 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_016931.2, NP_058627.1 |
| RefSeq Size | 2416 bp |
| RefSeq ORF | 1737 bp |
| Locus ID | 50507 |
| UniProt ID | Q9NPH5 |
| Protein Families | Druggable Genome, Transmembrane |
| Gene Summary | This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009] Transcript Variant: This variant (1) encodes isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Netrin-1 abrogates ischemia/reperfusion-induced cardiac mitochondrial dysfunction via nitric oxide-dependent attenuation of NOX4 activation and recoupling of NOS
,Siu, KL;Lotz, C;Ping, P;Cai, H;,
J. Mol. Cell. Cardiol. July 2014
,PubMed ID 25066694
[NOX4]
|
|
NADPH Oxidase 4 Induces Cardiac Arrhythmic Phenotype in Zebrafish
,Zhang, Y;Shimizu, H;Siu, KL;Mahajan, A;Chen, JN;Cai, H;,
J. Biol. Chem.
,PubMed ID 24962575
[NOX4]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208007 | NOX4 (Myc-DDK-tagged)-Human NADPH oxidase 4 (NOX4), transcript variant 1 |
CNY 4,304.00 |
|
| RC208007L1 | Lenti ORF clone of Human NADPH oxidase 4 (NOX4), transcript variant 1, Myc-DDK-tagged |
CNY 6,704.00 |
|
| RC208007L2 | Lenti ORF clone of Human NADPH oxidase 4 (NOX4), transcript variant 1, mGFP tagged |
CNY 6,704.00 |
|
| RC208007L3 | Lenti ORF clone of Human NADPH oxidase 4 (NOX4), transcript variant 1, Myc-DDK-tagged |
CNY 6,704.00 |
|
| RC208007L4 | Lenti ORF clone of Human NADPH oxidase 4 (NOX4), transcript variant 1, mGFP tagged |
CNY 6,704.00 |
|
| RG208007 | NOX4 (tGFP-tagged) - Human NADPH oxidase 4 (NOX4), transcript variant 1 |
CNY 5,904.00 |
|
| SC322623 | NOX4 (untagged)-Human NADPH oxidase 4 (NOX4), transcript variant 1 |
CNY 6,464.00 |
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