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MAP3K12 (NM_006301) Human Untagged Clone
CAT＃: SC310080
MAP3K12 (untagged)-Human mitogen-activated protein kinase kinase kinase 12 (MAP3K12), transcript variant 2
CNY 16,630.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DLK; MEKK12; MUK; ZPK; ZPKP1 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_006301, the custom clone sequence may differ by one or more nucleotides
ATGGCTTGCCTCCATGAGACCCGAACACCCTCTCCTTCCTTTGGGGGCTTTGTGTCTACC CTAAGTGAGGCATCCATGCGCAAGCTGGACCCAGACACTTCTGACTGCACTCCCGAGAAG GACCTGACGCCTACCCATGTCCTGCAGCTACATGAGCAGGATGCAGGGGGCCCAGGGGGA GCAGCTGGGTCACCTGAGAGTCGGGCATCCAGAGTTCGAGCTGACGAGGTGCGACTGCAG TGCCAGAGTGGCAGTGGCTTCCTTGAGGGCCTCTTTGGCTGCCTGCGCCCTGTCTGGACC ATGATTGGCAAAGCCTACTCCACTGAGCACAAGCAGCAGCAGGAAGACCTTTGGGAGGTC CCCTTTGAGGAAATCCTGGACCTGCAGTGGGTGGGCTCAGGGGCCCAGGGTGCTGTCTTC CTGGGGCGCTTCCACGGGGAGGAGGTGGCTGTGAAGAAGGTGCGAGACCTCAAAGAAACC GACATCAAGCACTTGCGAAAGCTGAAGCACCCCAACATCATCACTTTCAAGGGTGTGTGC ACCCAGGCTCCCTGCTACTGCATCCTCATGGAGTTCTGCGCCCAGGGCCAGCTGTATGAG GTACTGCGGGCTGGCCGCCCTGTCACCCCCTCCTTACTGGTTGACTGGTCCATGGGCATC GCTGGTGGCATGAACTACCTGCACCTGCACAAGATTATCCACAGGGATCTCAAGTCACCC AACATGCTAATCACCTACGACGATGTGGTGAAGATCTCAGATTTTGGCACTTCCAAGGAG CTGAGTGACAAGAGCACCAAGATGTCCTTTGCAGGGACAGTAGCCTGGATGGCCCCTGAG GTGATCCGCAATGAACCTGTGTCTGAGAAGGTCGACATCTGGTCCTTTGGCGTGGTGCTA TGGGAACTGCTGACTGGTGAGATCCCCTACAAAGACGTAGATTCCTCAGCCATTATCTGG GGTGTGGGAAGCAACAGTCTCCATCTGCCCGTGCCCTCCAGTTGCCCAGATGGTTTCAAG ATCCTGCTTCGCCAGTGCTGGAATAGCAAACCACGAAATCGCCCATCATTCCGACAGATC CTGCTGCATCTGGACATTGCCTCAGCTGATGTACTCTCCACACCCCAGGAGACTTACTTT AAGTCCCAGGCAGAGTGGCGGGAAGAAGTAAAACTGCACTTTGAAAAGATTAAGTCAGAA GGGACCTGTCTGCACCGCCTAGAAGAGGAACTGGTGATGAGGAGGAGGGAGGAGCTCAGA CACGCCCTGGACATCAGGGAGCACTATGAAAGGAAGCTGGAGAGAGCCAACAACCTGTAT ATGGAACTTAATGCCCTCATGTTGCAGCTGGAACTCAAGGAGAGGGAGCTGCTCAGGCGA GAGCAAGCTTTAGAGCGGAGGTGCCCAGGCCTGCTGAAGCCACACCCTTCCCGGGGCCTC CTGCATGGAAACACAATGGAGAAGCTTATCAAGAAGAGGAATGTGCCACAGAAGCTGTCA CCCCATAGCAAAAGGCCAGATATCCTCAAGACGGAGTCTTTGCTCCCTAAACTAGATGCA GCCCTGAGTGGGGTGGGGCTTCCTGGGTGTCCTAAGGCCCCCCCCTCACCAGGACGGAGT CGCCGTGGCAAGACCCGTCACCGCAAGGCCAGCGCCAAGGGGAGCTGTGGGGACCTGCCT GGGCTTCGTACAGCTGTGCCACCCCATGAACCTGGAGGACCAGGAAGCCCAGGGGGCCTA GGAGGGGGACCCTCAGCCTGGGAGGCCTGCCCTCCCGCCCTCCGTGGGCTTCATCATGAC CTCCTGCTCCGCAAAATGTCTTCATCGTCCCCAGACCTGCTGTCAGCAGCACTAGGGTCC CGGGGCCGGGGGGCCACAGGCGGAGCTGGGGATCCTGGCTCACCACCTCCGGCCCGGGGT GACACCCCACCAAGTGAGGGCTCAGCCCCTGGCTCCACCAGCCCAGATTCACCTGGGGGA GCCAAAGGGGAACCACCTCCTCCAGTAGGGCCTGGTGAAGGTGTGGGGCTTCTGGGAACT GGAAGGGAAGGGACCTCAGGCCGGGGAGGAAGCCGGGCTGGGTCCCAGCACTTGACCCCA GCTGCACTGCTGTACAGGGCTGCCGTCACCCGAAGTCAGAAACGTGGCATCTCATCGGAA GAGGAGGAAGGAGAGGTAGACAGTGAAGTAGAGCTGACATCAAGCCAGAGGTGGCCTCAG AGCCTGAACATGCGCCAGTCACTATCTACCTTCAGCTCAGAGAATCCATCAGATGGGGAG GAAGGCACAGCTAGTGAACCTTCCCCCAGTGGCACACCTGAAGTTGGCAGCACCAACACT GATGAGCGGCCAGATGAGCGGTCTGATGACATGTGCTCCCAGGGCTCAGAAATCCCACTG GACCCACCTCCTTCAGAGGTCATCCCTGGCCCTGAACCCAGCTCCCTGCCCATTCCACAC CAGGAACTTCTCAGAGAGCGGGGCCCTCCCAATTCTGAGGACTCAGACTGTGACAGCACT GAATTGGACAACTCCAACAGCGTTGATGCCTTGCGGCCCCCAGCTTCCCTCCCTCCATGA |
| Restriction Sites | Please inquire |
| ACCN | NM_006301 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_006301.2, NP_006292.2 |
| RefSeq Size | 3365 bp |
| RefSeq ORF | 2580 bp |
| Locus ID | 7786 |
| UniProt ID | Q12852 |
| Domains | pkinase, TyrKc, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | MAPK signaling pathway |
| Gene Summary | This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010] Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC216463 | MAP3K12 (Myc-DDK-tagged)-Human mitogen-activated protein kinase kinase kinase 12 (MAP3K12), transcript variant 2 |
CNY 9,120.00 |
|
| RC216463L1 | Lenti-ORF clone of MAP3K12 (Myc-DDK-tagged)-Human mitogen-activated protein kinase kinase kinase 12 (MAP3K12), transcript variant 2 |
CNY 11,020.00 |
|
| RC216463L2 | Lenti-ORF clone of MAP3K12 (mGFP-tagged)-Human mitogen-activated protein kinase kinase kinase 12 (MAP3K12), transcript variant 2 |
CNY 11,020.00 |
|
| RC216463L3 | Lenti-ORF clone of MAP3K12 (Myc-DDK-tagged)-Human mitogen-activated protein kinase kinase kinase 12 (MAP3K12), transcript variant 2 |
CNY 11,020.00 |
|
| RC216463L4 | Lenti-ORF clone of MAP3K12 (mGFP-tagged)-Human mitogen-activated protein kinase kinase kinase 12 (MAP3K12), transcript variant 2 |
CNY 11,020.00 |
|
| RG216463 | MAP3K12 (tGFP-tagged) - Human mitogen-activated protein kinase kinase kinase 12 (MAP3K12), transcript variant 2 |
CNY 11,664.00 |
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