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NEDD4 (NM_006154) Human Untagged Clone
CAT＃: SC310054
NEDD4 (untagged)-Human neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1
CNY 6,600.00
CNY 7,220.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | NEDD4-1; RPF1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_006154 edited
CTCCCGCTTCTCCTCCTCCTCCTCCACAGTTGCCTGCCCTGGGCGGGGGCGAGCGCGTCC GGTTTGCTGGAAGCGTTCGGAAATGGCAACTTGCGCGGTGGAGGTGTTCGGGCTCCTGGA GGACGAGGAAAATTCACGAATTGTGAGAGTAAGAGTTATAGCCGGAATAGGCCTTGCCAA GAAGGATATATTGGGAGCTAGTGATCCTTACGTGAGAGTGACGTTATATGACCCAATGAA TGGAGTTCTTACAAGTGTGCAAACAAAAACCATTAAAAAGAGTTTGAATCCAAAGTGGAA TGAAGAAATATTATTCAGAGTTCATCCTCAGCAGCACCGGCTTCTTTTTGAAGTGTTTGA CGAAAACCGATTGACAAGAGATGATTTCCTAGGTCAAGTGGATGTTCCACTTTATCCATT ACCGACAGAAAATCCAAGATTGGAGAGACCATATACATTTAAGGATTTTGTTCTTCATCC AAGAAGTCACAAATCAAGAGTTAAAGGTTATCTGAGACTAAAAATGACTTATTTACCTAA AACCAGTGGCTCAGAAGATGATAATGCAGAACAGGCTGAGGAATTAGAGCCTGGCTGGGT TGTTTTGGACCAACCAGATGCTGCTTGCCATTTGCAGCAACAACAAGAACCTTCTCCTCT ACCTCCAGGGTGGGAAGAGAGGCAGGATATCCTTGGAAGGACCTATTATGTAAACCATGA ATCTAGAAGAACACAGTGGAAAAGACCAACCCCTCAGGACAACCTAACAGATGCTGAGAA TGGCAACATTCAACTGCAAGCACAACGTGCATTTACCACCAGGCGGCAGATATCCGAGGA AACAGAAAGTGTTGACAACCAAGAGTCTTCCGAGAACTGGGAAATTATAAGAGAAGATGA AGCCACCATGTATAGCAGCCAGGCCTTCCCATCACCTCCACCGTCAAGTAACTTGGATGT TCCAACTCATCTTGCAGAAGAATTGAATGCCAGACTCACCATTTTTGGAAATTCAGCCGT GAGCCAGCCAGCATCGAGCTCAAATCATTCCAGCAGAAGAGGCAGCTTACAAGCCTATAC TTTTGAGGAACAACCTACACTTCCTGTGCTTTTGCCTACTTCATCTGGATTACCACCAGG TTGGGAAGAAAAACAAGATGAAAGAGGAAGATCATATTATGTAGATCACAATTCCAGAAC GACTACTTGGACAAAGCCCACTGTACAGGCCACAGTGGAGACCAGTCAGCTGACCTCAAG CCAGAGTTCTGCAGGCCCTCAATCACAAGCCTCCACCAGTGATTCAGGCCAGCAGGTGAC CCAGCCATCTGAAATTGAGCAAGGATTCCTTCCTAAAGGCTGGGAAGTCCGGCATGCACC AAATGGGAGGCCTTTCTTTATTGACCACAACACTAAAACCACCACCTGGGAAGATCCAAG ATTGAAAATTCCAGCCCATCTGAGAGGAAAGACATCACTTGATACTTCCAATGATCTAGG GCCTTTACCTCCAGGATGGGAAGAGAGAACTCACACAGATGGAAGAATCTTCTACATAAA TCACAATATAAAAAGAACACAATGGGAAGATCCTCGGTTGGAGAATGTAGCAATAACTGG ACCAGCAGTGCCCTACTCCAGGGATTACAAAAGAAAGTATGAGTTCTTCCGAAGAAAGTT GAAGAAGCAGAATGACATTCCAAACAAATTTGAAATGAAACTTCGCCGAGCAACTGTTCT TGAAGACTCTTACCGGAGAATTATGGGTGTCAAGAGAGCAGACTTCCTGAAGGCTCGACT GTGGATTGAGTTTGATGGTGAAAAGGGATTGGATTATGGAGGAGTTGCCAGAGAATGGTT CTTCCTGATCTCAAAGGAAATGTTTAACCCTTATTATGGGTTGTTTGAATATTCTGCTAC GGACAATTATACCCTACAGATAAATCCAAACTCTGGATTGTGTAACGAAGATCACCTCTC TTACTTCAAGTTTATTGGTCGGGTAGCTGGAATGGCAGTTTATCATGGCAAACTGTTGGA TGGTTTTTTCATCCGCCCATTTTACAAGATGATGCTTCACAAACCAATAACCCTTCATGA TATGGAATCTGTGGATAGTGAATATTACAATTCCCTAAGATGGATTCTTGAAAATGACCC AACAGAATTGGACCTCAGGTTTATCATAGATGAAGAACTTTTTGGACAGACACATCAACA TGAGCTGAAAAATGGTGGATCAGAAATAGTTGTCACCAATAAGAACAAAAAGGAATATAT TTATCTTGTAATACAATGGCGATTTGTAAACCGAATCCAGAAGCAAATGGCTGCTTTTAA AGAGGGATTCTTTGAACTAATACCACAGGATCTCATCAAAATTTTTGATGAAAATGAACT AGAGCTTCTTATGTGTGGACTGGGAGATGTTGATGTGAATGACTGGAGGGAACATACAAA GTATAAAAATGGCTACAGTGCAAATCATCAGGTTATACAGTGGTTTTGGAAGGCTGTTTT AATGATGGATTCAGAAAAAAGAATAAGATTACTTCAGTTTGTCACTGGCACATCTCGGGT GCCTATGAATGGATTTGCTGAACTATACGGTTCAAATGGACCACAGTCATTTACAGTTGA ACAGTGGGGTACGCCTGAAAAGCTGCCAAGAGCTCATACCTGTTTTAATCGCCTGGACTT GCCACCTTATGAATCATTTGAAGAATTATGGGATAAACTTCAGATGGCAATTGAAAACAC CCAGGGCTTTGATGGAGTTGATTAGATTACAAATAACAATCTGTAGTGTTTTTACTGCCA TAGTTTTATAACCAAAATCTTGACTTAAAATTTTCCGGGGAACTACTAAAATGTGGCCAC TGAGTCTTCCCAGATCTTGAAGAAAATCATATAAAAAGCATTTGAAGAAATAGTACGACA ACTTATTTTTAATCACTTTTAAATAATGTGTTGCATTTACACAGTTGTTTCATGCTGTCT TTAGAGTTAGGTGCCTGCCTAAAGCCAGGCACCACCACACCTGGCTTTAGAGTTCACACA ATAGGATATAAGTCCTGTATGACTTAAATAGTGAATTTTGTCCTTAACATTTACCTCTTG TATAGTATCTGCCAGGCAGTTTTTTCTTAAACTACTGAGATGATAACTGTGAAATATTTG TGATACGTGTCATGTGTGAAAAGTTTGATGCATTTTGAGATGGAAAACTGAAATTTGGAA AAAGAAATACTTTACTATTGAGTAAACTACAATATATTTAGTGCTACTCGCAGCTATTTA TTATTTTGTAGACCTGCCTTATGCACCTTACTGCCTAGATTTTTGGGAAAAAACTTTGGA AAGTGTGTTACCTATATTTCTAGCCAACTAACTCACAGAAAAACTGTTTACTTCTTCACT TTCGAAGTATTTGGCTTTTGTTAATATGCAGTTTTACTAAACAGATGGTTCATAAGACAT GTGAAGCAAATTCATATTTGCAATGGGTAAAAAGTATTAAAGCCTTTCTCTTGCCTGCAT ATCCTATTGACCATTGGTATAGTCATCACTTTTTCATATTTTAGTGTAGTTAGAAGAATT CCTTCTTCAAACATTAAAGATCCACAAAGCAGTATTTCTAAATATGCCTTGAAGAACTAA ATGAAGTGTATAGCACTTGCCTTTACTAGATATTCTTTACACTTGTACAATTATGTAGTA AATGTATGTTTACAGGGTTTATCATGTTTACAGATTAAGCTAATTTCTGTAGTCGCATTT TTATATTTTTAGTATCACTCTAGTAAAAAAACCAAATAATTTGTTTAAAATAACCAAAGA GTTGTTATAATGCATAATTTGTATTAAATTTATTACTATTTCTTATGCCTTTTAAAATAC TGTTTACTATGAAGACAATGTTTTTAATTACAAATCCAGAATTCTGTAGGCAAAATGCTA CAGTTCATATCTTCCTTTAACCAAACTGAAGTACATAAAGACCATGTACATGTATTCATC AAACGTTTATTGAATGCTGCGTGCCTAGCGCTGTGCTATGCTCTGGGGTAAGAGTTGTCA GCTTCAGAGAAGCTGAGTCCTGATCCTCAAGGAACTTGCAAATGTGTCTATGAATTTGTA AAACAATCAAAAGTAGGCGTAAGCAGAATAAGGCAAAAGGGAAAGTGTTCTAGGTTCCAG CACACCTGCAAAGATAAAGTGTGCCAAGACTGTATTTATATTTCATACTTATATTGTTTC ATCCTTATATTGGAATGATTATATAGAAAATGCTCTTAAAAAGATTAAACCTATTTCTCA GTATGGTATCTTGGTGATTTAGGAATAATTGTAAATATATGTTACGAATCTTCTTAAATA TATATATATACACACCCTGTGAGAACTGTAAAAAGTACCTCTGGTTCTTGGTTTAAGTTT GTTGGGGTATAACATGATGAGTACTCATTAGCACCTGATAGAAATCTGAAATGTGACAGT AGCAAAACCACTTTCTACTTTCCAAACACCACAGCATCAGCATGGTTTAGGGGAAGCAAT TCACAGATTAATGTACCCTGCGTTTTGTCTTCACCATTGTCAACCAGCAGTCAAGGATGA GCACCAGGTATAGTCCTGGTTTGATATCTCACCAGCCATGTGAACTGAAGCAGCTTACTT AACCTCTCTGGATTCATATTTCTTCATCTGTCAAATGAGAGTAATCATGCCCACCCTCAT TGTCATGGCAGATTGTCAGAAGTTCCAGACAGATGAGAAAGCAAAAAGTACTTTGTAAAG TGTTATACAATCAGAAGGTGCTTTGTGCTGACCGTCAGATTGTGTCAAGTCAGGTGTGCA AATTGACCACACTCCCAAAGAATCATTTAAAAGTAAAGTGACTTCTAAGAGACAAGGAAG TAGGAACATTTCTGATATTAAATATATAAATAATATGGATACACATGTGTATATCTGTAT ATGGATCTTACCATCATAATTCATTTTCTTCATATCAGCAAAGTAATAGTAATGTGGGCC AATGCATTTTGGAAATGTCCTCATTATGTAGAATGGAATGTGAAAATTATTTTTGTTAAA ACAGGATTTTGCCACAATTATTTAAATATTATGTTTGTGAACTATCTAAGCATGAGAAAA TACAAAGCTTTCTTTGTATCTGGCTGATACTCATTTGGATGATTCTGTGACTCATAGAAC ATGATGTTAAATGAGACCAGACTCAACTGCCACCAGTCCCCAGCTGCAGACCTTCATCCC CTTCATCTCCCACTAGGGGCTCGTGGTCTGGAAGAAACATGTATCAAGCAACACAGCCCC TTATCCCAGATAGAAAAGTGTCTCAAATGCATTCTACTGCGGGACAGTCAGTAGGATCAT TTTCATAAAGCAAGGACATCATATGTTTCTAGAAATTACAAGCATATAACTTTAGCCTAC AATCTCTTATTAAAAATTTTTAACAAAATTGTATTACAAATGCATTTCATCAGAACTCAA ATTTAAATGGTGTTTGTTTTGGGTTTTTATTTATAATGCTGAAGTTATTCCATATAAGTA TCAAGTTAAACACAATTCATTTTGATTATAAACTATTTGACTTTTTAAAATCTTCTGACA CAGTAAATATATATATCAAGATTGATGTATCAAAATTTATTGCACACTTTAAAGTGTAAA ATCATTTTTTAAAATCTTGAATCCACAAATAAAGTTCTATTCTGATTTTAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_006154 |
| Insert Size | 5900 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The ORF of this clone has been fully sequenced and found to contain 2 SNPs compared with NM_006154.1. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_006154.1, NP_006145.1 |
| RefSeq Size | 5749 bp |
| RefSeq ORF | 2703 bp |
| Locus ID | 4734 |
| UniProt ID | P46934 |
| Protein Families | Druggable Genome |
| Protein Pathways | Endocytosis, Ubiquitin mediated proteolysis |
| Gene Summary | This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016] Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains multiple alternate 5' coding exons, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (1) is shorter and has a distinct N-terminus, compared to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN
,Hong, SW;Moon, JH;Kim, JS;Shin, JS;Jung, KA;Lee, WK;Jeong, SY;Hwang, JJ;Lee, SJ;Suh, YA;Kim, I;Nam, KY;Han, S;Kim, JE;Kim, KP;Hong, YS;Lee, JL;Lee, WJ;Choi, EK;Lee, JS;Jin, DH;Kim, TW;,
Cell Death Differ. 2013 Oct 18.
,PubMed ID 24141722
[NEDD4]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221706 | NEDD4 (Myc-DDK-tagged)-Human neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1 |
CNY 6,592.00 |
|
| RC221706L1 | Lenti ORF clone of Human neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1, Myc-DDK-tagged |
CNY 8,992.00 |
|
| RC221706L2 | Lenti ORF clone of Human neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC221706L3 | Lenti ORF clone of Human neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1, Myc-DDK-tagged |
CNY 8,992.00 |
|
| RC221706L4 | Lenti ORF clone of Human neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1, mGFP tagged |
CNY 8,992.00 |
|
| RG221706 | NEDD4 (tGFP-tagged) - Human neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1 |
CNY 8,192.00 |
