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Hexokinase II (HK2) (NM_000189) Human Untagged Clone
CAT＃: SC309063
HK2 (untagged)-Human hexokinase 2 (HK2)
CNY 10,080.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HKII; HXK2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000189 edited
GAAACTCCGGCGCAGGAGTCCCGGGCTGCCGCTGGCAACATCGTGTCACCCAGCTAAGAA AATCCGCGGGCCCGAGCCACGCGCCTGTGAATCGGAGAGGTCCCACTGCCCGAGTGGAGC CGGGCTGAGATTCTTCTCAAGTTGAGCCTCAGTGATCCTGTGGCCGAAGTTAGCGCCTTG ACGTGGGACAACCGGACACGTCGCCAGGACAGAACTGAGGCGCCTTCTAGCAGTTGTGAC GCCAAAATCACGTCTCCGGAGACCCGCGCCCTCCGCCAGCCGGGCGCACCCTCGCCGGTA GCCTTCTTTGTGCGCCGTCCGGACTCCCAGCTCCCGGCCCGGCAGCCGAGCCCCAGCACA AAGCAGTCGGACCGCGCCGCCCGCCTCCCCTCTCGCGTCTCCGCCTCGGTTTCCCAACTC TGCGCCGTCGGGCCGCGGCAGGATGATTGCCTCGCATCTGCTTGCCTACTTCTTCACGGA GCTCAACCATGACCAAGTGCAGAAGGTTGACCAGTATCTCTACCACATGCGCCTCTCTGA TGAGACCCTCTTGGAGATCTCTAAGCGGTTCCGCAAGGAGATGGAGAAAGGGCTTGGAGC CACCACTCACCCTACTGCAGCAGTGAAGATGCTGCCCACCTTTGTGAGGTCCACTCCAGA TGGGACAGAACACGGAGAGTTCCTGGCTCTGGATCTTGGAGGGACCAACTTCCGTGTGCT TTGGGTGAAAGTAACGGACAATGGGCTCCAGAAGGTGGAGATGGAGAATCAGATCTATGC CATCCCTGAGGACATCATGCGAGGCAGTGGCACCCAGCTGTTTGACCACATTGCCGAATG CCTGGCTAACTTCATGGATAAGCTACAAATCAAAGACAAGAAGCTCCCACTGGGTTTTAC CTTCTCGTTCCCCTGCCACCAGACTAAACTAGACGAGAGTTTCCTGGTCTCATGGACCAA GGGATTCAAGTCCAGTGGAGTGGAAGGCAGAGACGTTGTGGCTCTGATCCGGAAGGCCAT CCAGAGGAGAGGGGACTTTGATATCGACATTGTGGCTGTGGTGAATGACACAGTTGGGAC CATGATGACCTGTGGTTATGATGACCACAACTGTGAGATTGGTCTCATTGTGGGCACGGG CAGCAACGCCTGCTACATGGAAGAGATGCGCCACATCGACATGGTGGAAGGCGATGAGGG GCGGATGTGTATCAATATGGAGTGGGGGGCCTTCGGGGACGATGGCTCGCTCAACGACAT TCGCACTGAGTTTGACCAGGAGATTGACATGGGCTCACTGAACCCGGGAAAGCAACTGTT TGAGAAGATGATCAGTGGGATGTACATGGGGGAGCTGGTGAGGCTTATCCTGGTGAAGAT GGCCAAGGAGGAGCTGCTCTTTGGGGGGAAGCTCAGCCCAGAGCTTCTCAACACCGGTCG CTTTGAGACCAAAGACATCTCAGACATTGAAGGGGAGAAGGATGGCATCCGGAAGGCCCG TGAGGTCCTGATGCGGTTGGGCCTGGACCCGACTCAGGAGGACTGCGTGGCCACTCACCG GATCTGCCAGATCGTGTCCACACGCTCCGCCAGCCTGTGCGCAGCCACCCTGGCCGCCGT GCTGCAGCGCATCAAGGAGAACAAAGGCGAGGAGCGGCTGCGCTCTACTATTGGGGTCGA CGGTTCCGTCTACAAGAAACACCCCCATTTTGCCAAGCGTCTACATAAGACCGTGCGGCG GCTGGTGCCCGGCTGCGATGTCCGCTTCCTCCGCTCCGAGGATGGCAGTGGCAAAGGTGC AGCCATGGTGACAGCAGTGGCTTACCGGCTGGCCGATCAACACCGTGCCCGCCAGAAGAC ATTAGAGCATCTGCAGCTGAGCCATGACCAGCTGCTGGAGGTCAAGAGGAGGATGAAGGT AGAAATGGAGCGAGGTCTGAGCAAGGAGACTCATGCCAGTGCCCCCGTCAAGATGCTGCC CACCTACGTGTGTGCTACCCCGGACGGCACAGAGAAAGGGGACTTCTTGGCCTTGGACCT TGGAGGAACAAATTTCCGGGTCCTGCTGGTCCGTGTTCGGAATGGGAAGTGGGGTGGAGT GGAGATGCACAACAAGATCTACGCCATCCCGCAGGAGGTCATGCACGGCACCGGGGACGA GCTCTTTGACCACATTGTCCAGTGCATCGCGGACTTCCTCGAGTACATGGGCATGAAGGG CGTGTCCCTGCCTCTGGGTTTTACCTTCTCCTTCCCCTGCCAGCAGAACAGCCTGGACGA GAGCATCCTCCTCAAGTGGACAAAAGGCTTCAAGGCATCTGGCTGCGAGGGCGAGGACGT GGTGACCCTGCTGAAGGAAGCGATCCACCGGCGAGAGGAGTTTGACCTGGATGTGGTTGC TGTGGTGAACGACACAGTCGGAACTATGATGACCTGTGGCTTTGAAGACCCTCACTGTGA AGTTGGCCTCATTGTTGGCACGGGCAGCAATGCCTGCTACATGGAGGAGATGCGCAACGT GGAACTGGTGGAAGGAGAAGAGGGGCGGATGTGTGTGAACATGGAATGGGGGGCCTTCGG GGACAATGGATGCCTAGATGACTTCCGCACAGAATTTGATGTGGCTGTGGATGAGCTTTC ACTCAACCCCGGCAAGCAGAGGTTCGAGAAAATGATCAGTGGAATGTACCTGGGTGAGAT TGTCCGTAACATTCTCATCGATTTCACCAAGCGTGGACTACTCTTCCGAGGCCGCATCTC AGAGCGGCTCAAGACAAGGGGCATCTTTGAAACCAAGTTCTTGTCTCAGATTGAGAGTGA CTGCCTGGCCCTGCTGCAAGTCCGAGCCATCCTGCAACACTTAGGGCTTGAGAGCACCTG TGACGACAGCATCATTGTTAAGGAGGTGTGCACTGTGGTGGCCCGGCGGGCAGCCCAGCT CTGTGGCGCAGGCATGGCCGCTGTGGTGGACAGGATACGAGAAAACCGTGGGCTGGACGC TCTCAAAGTGACAGTGGGTGTGGATGGGACCCTCTACAAGCTACATCCTCACTTTGCCAA AGTCATGCATGAGACAGTGAAGGACCTGGCTCCGAAATGTGATGTGTCTTTCCTGCAGTC AGAGGATGGCAGCGGGAAGGGGGCGGCGCTCATCACTGCTGTGGCCTGCCGCATCCGTGA GGCTGGACAGCGATAGAACCCCTGAAATCGGAAGGGACTTCCTCTTTCTCTCCTTCTTCC CTGTTTTAAATTATAAGATGTCATCCCCTTGTGTCAGAGACAGACCCCTTGGCTTTTGCT TGGCAGAGAGGACCCCACTGGACTGGGTTTTGTCTCTGCATCTCATTGTAGAGCTTGGTG GCTGAGCTTGGCCCTATTAAGATAAATAGAGTTCCAAATAAGGATTTGTTCACATGCATC ATAACCATTCCCATTGGTTCTCCTAAAACATGAAAATTATCTCCCTTAGTAATCCCCCTT GCCAAATTCCATGTCCCTGTATAATTCTACAGGATGGGGACACTAATGAAGATACGGTTG CTTCACCTTGGAGCCTGAACATGACATTTCTAAGTGGGGTGCATCCCCCAGCACTGATGT TGTTACTGATTCTCCTGTCAGAGATCTGGGAGGTCTCCACTGAGGATGTGAGCCTGATTA TCCTATAGGCAGACGTGGGGAGGGTGGAGGGGTGACAGTGGAGGAAAATCCATGGATATC CACGCAGCAGCCCCTCTTTAACCTCATCTACAAGCATTTGCCCTGTGGATTCCAGCATTT GCCATTCCTGGAATCAAGGAATCCTGAGTCTGGGCAATGAAACCAAAGCCAGGAGTTGAC GCATCCTGCAGTTGGGCCAGCTGTCGCATCTCAGCGGGGCGCACATGTTATCCACAAGCA ATGGACCTTTGGGGAAGGGGGAGTTTTTAGTTTGTTTTACAAATTTTTCCTGCAAAAGTG GAATCACTGTATTTTCATTTTAATTTATATTTGAAATTTTATTTAGTTCTTGAGCATCTG CTTCTTCATCTTGACATGTAATGAATGGTCAGTTGTACGTAATGTATTTATATGTTAATT TGTTATGTATATAGATGTGCAAGTCTTGTCAGAATTGGCCTCAGTGTAGTTAAAGGGCAG AAGGGGAAGATACTGACTAGTCATAGAAATACCTCATTCGCCTGTGGGAAGAGAAGGGAA GCCTCTTCAGGGTGAGTGAATGGCAAAGCGGTTGCTTCTGGCTCCTCCTTCCCCTGTGGT CTTGGAAGTGTGTGGAAGGCAGGGACAGAGATGGAGGCCGAGCCAATAGACTGAAGAGAC CACAGCAATTGGCTCCTCCATCTAGAGATTTTCTTGGCAGTATTCCATGGGATGTTAAGC AAAGGAAACCAAAGGAATCGTTTCAAATGGACTCATGGCTTAGAAATCTTTATTCTTAGG GCAGTCAGTAGTATTCTAAAGCTTTCTGACAAGATAAAGGAAGTCACCAAAATTTCTTTT TTTAAATTGTATCTAATCCTCAACAACAAACCAAAACAGAACAATTAAACAGCCAAATAA AACCTCAGGGACAACATTTTTGGTGTATTTGAGCCCTCCCAGCAAGTTTCACCTTGGGTT TGTATTTTAAATGTTTTACAAGAATTGTCCATGTGCTTCCCTAGGCTGAGCTGGCATTGG TCTGCTGACCTGTTTTTGTGTTTTTCTTTTTTTTATACACAACATTTATTTCAAACTATT GGGAGGGATGAGAGTGGCTTAAAAACTTCCATCCCTACTTTTCAAGAGTGCAGTTGATTC TGAATCTGAAAGCCCGCCTCTGTCCTAAAATACAAACAAGCACAGACATTAAACCTGGAT ACTATATGATAAAGAGGGATGTAACTATTGAATTGGATACAAGGATCAGAATGGAAAGAA ACTCACGATGAAATTGAACCTGGTTTTTGTATATTTATCAAACTTGTGCTGAGAATAGTG TCTGATTATACGACTTTTAAGCAAAGTTGGGTGTAATTAGGTGAAAACAGCCCAGGTCCT CCCGGGAGCACAGAGGGGCTAGGGGCTGGTCCTTCTCGTTTGCTCTAGTCTTGCTTTGCT GTCTGGTGTAGCTCCTCTGCTGCTCCCATCTGCACTAATTGACCCAAAACGTGGGTATTT CCTGCTACACAAAAGCCAAAAGGTTTCATGTAGATTTTAGTTCACTAAAGGGTGCCCACA AAATAGAGATTAATTTTAACTTAAATTTTAAGCTTGAAGATTAGGTACTATCTGTGAAGT TACACTTTTTTTTTTTTTTTTAAAGGTAGAGATGTGTGTGTGTGTAGGTATTAAAGATGT GTTGTTGGTTTCCAAAAAGGAACACTGGAAAATAAATTTTGAATGTTTATGTTCTCAGAA TCAGGTTGACAGTCCCTTGCTGACATGGCTTTGCTTTGTGTAAATACAGTGGATCTCAAT CTTCGGGGTGTGATGAATAGCGAATCATCTCAAATCCTTGAGCACTCAGTCTAGTGAAGA TGTTGTCATTATGTACAATACATAACTAGTTTAATTAACTATGTGATGTTAACTATTATT AATAAATTTTAACATTTTCCAAAATAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_000189 unedited
GTTCGGATTTGNTATACGACTTACTATAGGGCGGCCGCAATCTAGAGTCGACAAGCTTGA TATCGGTACCGGTCCGGAATTCCCGGGATATCGTCGACCCACGCGTCCGGAAACTCCGGC GCAGGAGTCCCGGGCTGCCGCTGGCAACATCGTGTCACCCAGCTAAGAAAATCCGCGGGC CCGAGCCACGCGCCTGTGAATCGGAGAGGTCCCACTGCCCGAGTGGAGCCGGGCTGAGAT TCTTCTCAAGTTGAGCCTCAGTGATCCTGTGGCCGAAGTTAGCGCCTTGACGTGGGACAA CCGGACACGTCGCCAGGACAGAACTGAGGCGCCTTCTAGCAGTTGTGACGCCAAAATCAC GTCTCCGGAGACCCGCGCCCTCCGCCAGCCGGGCGCACCCTCGCCGGTAGCCTTCTTTGT GCGCCGTCCGGACTCCCAGCTCCCGGCCCGGCAGCCGAGCCCCAGCACAAAGCAGTCGGA CCGCGCCGCCCGCCTCCCCTCTCGCGTCTCCGCCTCGGTTTCCCAACTCTGCGCCGTCGG GCCGCGGCAGGATGATTGCCTCGCATCTGCTTGCCTACTTCTTCACGGAGCTCAACCATG ACCAAGTGCAGAAGGTTGACCAGTATCTCTACCACATGCGCCTCTCTGATGAGACCCTCT TGGAGATCTCTAAGCGGTTCCGCAAGGAGATGGGAGAAAGGGCTTGGAGCCACCACTCAC CCTACTGCAGCAGTGAAGATGCTGCCCACCTTTGTGAGGTCCACTCCAGATGGGACAGAA CACGGAGAGTTCCTTGGCTCTGGATCTTGGAGGGACCCACTCCCGTGTGCTTTGGNTGAA AAGTACGGACAATGGGCTCCAAAAGTGG |
| Restriction Sites | Please inquire |
| ACCN | NM_000189 |
| Insert Size | 5600 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000189.4, NP_000180.2 |
| RefSeq Size | 7109 bp |
| RefSeq ORF | 2754 bp |
| Locus ID | 3099 |
| UniProt ID | P52789 |
| Domains | hexokinase |
| Protein Families | Druggable Genome |
| Protein Pathways | Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism, Galactose metabolism, Glycolysis / Gluconeogenesis, Insulin signaling pathway, Metabolic pathways, Starch and sucrose metabolism, Type II diabetes mellitus |
| Gene Summary | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma
,Penny, HL;Sieow, JL;Adriani, G;Yeap, WH;Ee, PS;Luis, BS;Lee, B;Lee, T;Mak, SY;Ho, YS;Ong, CK;Huang, RY;Ginhoux, F;Rotzschke, O;Kamm, RD;Wong, SC;,
OncoImmunology
,PubMed ID 27622062
[HK2]
|
|
HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
,Ong, SG;Lee, WH;Theodorou, L;Kodo, K;Lim, SY;Shukla, DH;Briston, T;Kiriakidis, S;Ashcroft, M;Davidson, SM;Maxwell, PH;Yellon, DM;Hausenloy, DJ;,
Cardiovasc. Res. July 2014
,PubMed ID 25063991
[HK2]
|
|
The Regulation of Apoptosis by the Downstream Regulatory Element Antagonistic Modulator/Potassium Channel Interacting Protein 3 (DREAM/KChIP3) Through Interactions with Hexokinase I
,null,
Biochemical and biophysical research communications
,PubMed ID 23524266
[HK2]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209482 | HK2 (Myc-DDK-tagged)-Human hexokinase 2 (HK2) |
CNY 10,072.00 |
|
| RC209482L1 | Lenti ORF clone of Human hexokinase 2 (HK2), Myc-DDK-tagged |
CNY 12,472.00 |
|
| RC209482L2 | Lenti ORF clone of Human hexokinase 2 (HK2), mGFP tagged |
CNY 5,890.00 |
|
| RC209482L3 | Lenti ORF clone of Human hexokinase 2 (HK2), Myc-DDK-tagged |
CNY 12,472.00 |
|
| RC209482L4 | Lenti ORF clone of Human hexokinase 2 (HK2), mGFP tagged |
CNY 5,890.00 |
|
| RG209482 | HK2 (tGFP-tagged) - Human hexokinase 2 (HK2) |
CNY 11,672.00 |
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