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Plectin (PLEC) (NM_201381) Human Untagged Clone
CAT＃: SC308016
PLEC (untagged)-Human plectin (PLEC), transcript variant 7
CNY 86,930.00
货期*
详询
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | EBS1; EBSMD; EBSND; EBSO; EBSOG; EBSPA; HD1; LGMD2Q; LGMDR17; PCN; PLEC1; PLEC1b; PLTN |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_201381, the custom clone sequence may differ by one or more nucleotides
ATGAAGATCGTGCCCGATGAGCGGGATCGTGTGCAGAAGAAAACCTTCACCAAGTGGGTC AACAAGCACCTCATCAAGGCCCAGAGGCACATCAGTGACCTGTATGAAGACCTCCGCGAT GGCCACAACCTCATCTCCCTGCTGGAGGTCCTCTCGGGGGACAGCCTGCCCCGGGAGAAG GGGAGGATGCGTTTCCACAAGCTGCAGAATGTCCAGATTGCCCTGGACTACCTCCGGCAC CGCCAGGTGAAGCTGGTGAACATCAGGAATGATGACATCGCTGACGGCAACCCCAAGCTG ACCCTTGGCCTCATCTGGACAATCATTCTGCACTTCCAGATCTCAGATATCCAGGTGAGT GGGCAGTCGGAGGACATGACGGCCAAGGAGAAGCTGCTGCTGTGGTCGCAGCGAATGGTG GAGGGGTACCAGGGCCTGCGATGCGACAACTTCACCTCCAGCTGGAGAGACGGCCGCCTC TTCAATGCCATCATCCACCGGCACAAGCCCCTGCTCATCGACATGAACAAGGTGTACCGG CAGACCAACCTGGAGAACCTGGACCAGGCCTTCTCTGTGGCGGAGCGGGACCTGGGAGTG ACGCGGCTCCTGGACCCTGAGGACGTGGATGTCCCTCAGCCCGACGAGAAGTCCATCATC ACCTACGTCTCGTCGCTGTATGACGCCATGCCCCGCGTGCCGGACGTGCAGGATGGGGTG AGGGCCAACGAGCTGCAGCTGCGCTGGCAGGAGTACCGGGAGCTGGTGCTGCTGCTGCTT CAGTGGATGCGACACCACACGGCCGCCTTTGAGGAACGCAGGTTCCCCTCCAGCTTCGAG GAGATTGAGATCCTGTGGTCTCAGTTCCTGAAGTTTAAGGAGATGGAGCTACCAGCCAAG GAGGCCGACAAGAACAGGTCCAAGGGCATCTACCAATCCCTGGAGGGAGCGGTGCAAGCA GGCCAGCTCAAGGTGCCCCCTGGCTACCACCCGCTGGATGTGGAGAAGGAGTGGGGCAAG CTGCACGTGGCCATCCTGGAGCGGGAGAAGCAGCTCCGCAGCGAGTTTGAGAGGCTGGAG TGTCTTCAGCGCATCGTGACCAAGCTGCAGATGGAGGCGGGGCTGTGTGAGGAGCAGCTG AACCAGGCCGACGCCCTGCTGCAGTCGGATGTCCGGCTGCTGGCTGCAGGCAAAGTGCCA CAGCGGGCGGGGGAGGTGGAACGGGACTTGGACAAGGCGGATAGCATGATCCGGCTGCTC TTCAACGACGTGCAGACCCTCAAGGATGGACGGCACCCGCAGGGCGAGCAGATGTACCGC AGGGTGTACCGTCTGCACGAGCGCCTGGTAGCCATCCGCACCGAGTACAACCTACGGCTG AAGGCAGGCGTGGCGGCCCCTGCAACCCAGGTGGCCCAGGTGACTCTGCAGAGTGTGCAG AGGCGCCCCGAGCTGGAGGACTCCACTCTGCGCTACCTGCAGGACCTGCTGGCCTGGGTG GAGGAGAACCAGCACCGTGTGGATGGCGCTGAGTGGGGTGTGGACCTGCCCAGCGTGGAG GCGCAGCTGGGCAGCCACCGAGGCCTGCACCAGTCCATCGAAGAATTCCGGGCCAAGATC GAGCGGGCACGGAGTGACGAGGGCCAGCTCTCCCCCGCCACCCGGGGTGCCTACCGTGAC TGCCTGGGTCGGCTGGACCTGCAGTACGCCAAGCTGCTGAACTCCTCCAAGGCCCGCCTC AGGTCCCTGGAGAGCTTGCACAGCTTTGTGGCAGCCGCCACTAAGGAGCTAATGTGGCTG AATGAGAAGGAGGAGGAGGAGGTGGGCTTCGACTGGAGCGACCGCAACACCAACATGACC GCCAAGAAGGAGAGCTACTCGGCGCTGATGCGGGAGCTGGAGCTGAAGGAGAAGAAGATC AAGGAGCTCCAAAATGCTGGGGACCGGCTGCTGCGGGAGGACCACCCGGCCCGGCCCACG GTGGAGTCCTTCCAGGCGGCCCTGCAGACGCAGTGGAGCTGGATGCTACAGCTGTGCTGC TGTATCGAGGCACACCTGAAGGAGAACGCTGCCTACTTTCAGTTCTTCTCAGATGTGCGG GAGGCCGAGGGGCAGTTGCAGAAGCTGCAGGAGGCACTGCGTAGGAAATACAGTTGTGAT CGCTCCGCCACCGTCACCCGGCTGGAGGACCTGCTGCAGGATGCCCAGGACGAGAAGGAA CAGCTGAACGAGTACAAGGGCCACCTCTCAGGCCTGGCCAAGCGGGCCAAGGCCGTCGTG CAGCTGAAGCCCCGCCACCCAGCCCACCCCATGCGGGGCCGCCTGCCCCTGCTGGCCGTG TGCGACTATAAGCAGGTGGAGGTGACTGTGCACAAGGGTGACGAGTGCCAGCTGGTGGGC CCTGCACAGCCGTCCCACTGGAAGGTGCTCAGCAGCTCCGGCAGCGAGGCCGCCGTGCCC TCCGTGTGCTTCCTGGTGCCCCCGCCCAACCAGGAGGCCCAGGAGGCCGTCACCAGGCTG GAGGCCCAGCACCAGGCCCTGGTCACGCTGTGGCACCAGTTGCACGTGGACATGAAGAGC CTTCTGGCCTGGCAGAGCCTTCGCCGCGACGTGCAGCTCATCCGCTCCTGGTCCCTGGCC ACGTTCCGCACCCTGAAGCCAGAGGAGCAGCGCCAAGCCCTGCACAGCCTGGAGCTGCAC TACCAGGCCTTCCTGCGGGACAGCCAGGACGCGGGCGGCTTCGGACCCGAGGACCGGCTG ATGGCTGAGCGCGAGTACGGCTCCTGCAGCCACCACTACCAGCAGCTGCTGCAGAGCCTG GAACAGGGTGCACAGGAAGAGTCTCGCTGCCAGCGCTGCATCTCCGAGCTCAAAGACATC CGGCTGCAGCTGGAGGCCTGTGAGACGCGCACCGTGCACCGCCTGCGGCTGCCGCTGGAC AAAGAGCCGGCACGGGAGTGTGCCCAGCGCATCGCCGAGCAGCAGAAGGCACAGGCAGAG GTGGAGGGGCTGGGCAAGGGGGTCGCCCGGCTCTCTGCCGAGGCCGAGAAGGTCTTGGCC CTACCAGAGCCATCGCCTGCGGCCCCCACGCTGCGCTCGGAGCTGGAGCTGACGCTGGGC AAGCTGGAGCAGGTCCGCAGCCTGTCTGCCATCTACCTGGAGAAGCTCAAGACCATCAGC CTGGTGATCCGCGGCACGCAGGGGGCCGAGGAGGTGCTCAGGGCCCACGAGGAGCAGCTC AAGGAGGCCCAGGCCGTGCCGGCCACCCTCCCGGAGCTCGAGGCCACCAAGGCCTCTCTG AAGAAGCTGCGGGCCCAGGCCGAGGCACAGCAGCCCACGTTCGACGCCCTGCGGGATGAG CTGCGGGGGGCACAGGAGGTGGGGGAGCGACTGCAGCAGCGGCACGGGGAGCGGGACGTG GAGGTGGAGCGCTGGCGGGAGCGGGTCGCCCAGTTGCTTGAGCGCTGGCAGGCTGTGCTG GCCCAGACCGACGTGCGGCAGCGCGAGCTCGAGCAACTGGGCCGCCAGCTGCGTTACTAC CGCGAGAGTGCAGACCCCTTGGGCGCCTGGCTGCAGGACGCCAGGCGGCGGCAGGAGCAG ATCCAGGCCATGCCGCTGGCCGACAGCCAGGCTGTGCGGGAGCAGCTGCGGCAGGAGCAG GCCCTGCTGGAGGAGATCGAGCGCCACGGCGAGAAGGTCGAGGAGTGCCAGAGGTTTGCG AAACAGTACATCAACGCCATCAAGGACTATGAACTCCAGCTGGTGACGTACAAGGCGCAG CTTGAGCCGGTGGCCTCCCCGGCCAAGAAGCCCAAGGTCCAGTCGGGATCAGAGAGTGTC ATCCAGGAGTACGTGGACCTGCGTACGCACTACAGCGAGCTGACCACACTGACGAGCCAG TACATCAAGTTCATCAGCGAGACTCTGCGGCGCATGGAGGAGGAGGAGAGGCTGGCTGAG CAGCAGCGGGCAGAGGAGCGCGAGCGGCTGGCCGAGGTGGAGGCCGCGCTGGAGAAGCAG CGGCAGCTGGCCGAGGCGCACGCCCAGGCAAAGGCACAGGCGGAGCGGGAGGCGAAGGAG CTGCAGCAGCGCATGCAGGAGGAGGTGGTGCGGCGGGAGGAGGCGGCGGTGGACGCGCAG CAGCAGAAGCGCAGCATTCAGGAGGAGCTGCAGCAGCTGCGGCAGAGCTCGGAGGCGGAG ATCCAGGCCAAGGCCCGGCAGGCAGAGGCGGCTGAGCGCAGCCGGCTGCGCATCGAGGAG GAGATCCGCGTGGTGCGCCTGCAGTTGGAGGCCACCGAGCGCCAGCGTGGCGGGGCTGAG GGGGAGCTGCAGGCACTGCGTGCACGGGCGGAGGAGGCTGAGGCACAAAAGCGACAGGCG CAGGAGGAGGCCGAGCGCTTGCGGAGGCAGGTGCAGGACGAGAGCCAGCGTAAGCGGCAG GCGGAGGTGGAGCTGGCCTCGCGCGTGAAGGCCGAGGCCGAGGCGGCGCGCGAGAAGCAG CGGGCCCTGCAGGCCCTGGAGGAGCTGCGGCTGCAGGCGGAGGAGGCGGAGCGGCGCCTG CGGCAGGCCGAGGTGGAGCGAGCGCGGCAGGTACAGGTGGCCCTGGAGACGGCGCAGCGC AGTGCAGAGGCGGAGCTGCAGAGCAAACGCGCCTCCTTCGCCGAGAAGACGGCACAGCTG GAGCGCTCCCTGCAGGAGGAACACGTGGCTGTGGCACAGCTGCGGGAGGAGGCTGAGCGG CGGGCACAGCAGCAGGCCGAGGCCGAGCGGGCGCGCGAGGAGGCAGAGCGGGAGCTGGAG CGCTGGCAGCTCAAGGCCAACGAGGCGCTACGGCTGCGGCTGCAGGCGGAGGAGGTGGCG CAGCAGAAGAGCCTGGCGCAGGCCGAGGCTGAGAAGCAGAAGGAGGAGGCGGAGCGCGAG GCGCGGCGGCGCGGCAAGGCGGAGGAGCAGGCCGTCCGGCAGCGGGAGCTGGCTGAACAA GAGCTGGAGAAGCAGCGGCAGCTGGCGGAAGGCACCGCGCAGCAGCGCCTGGCCGCGGAG CAGGAGTTGATCCGGCTGCGGGCCGAGACGGAGCAGGGGGAGCAGCAGCGGCAGCTGCTG GAGGAGGAGCTGGCCCGGCTGCAGCGTGAGGCGGCTGCAGCCACGCAGAAACGGCAGGAG CTGGAAGCCGAGCTGGCCAAGGTGCGGGCCGAGATGGAGGTGCTGCTGGCCAGCAAGGCG AGGGCTGAGGAGGAGTCGCGCTCCACCAGCGAGAAGTCCAAGCAGAGGCTGGAGGCCGAG GCCGGCCGGTTCCGCGAGCTGGCCGAGGAGGCCGCCCGCCTGCGTGCCCTGGCGGAAGAG GCCAAGCGGCAGCGGCAGCTGGCCGAGGAAGACGCGGCGCGGCAGCGGGCCGAGGCGGAG CGGGTGCTTGCGGAGAAGCTGGCCGCCATCGGCGAGGCCACGCGGCTCAAGACGGAGGCG GAGATCGCGCTCAAGGAGAAGGAGGCGGAGAACGAGCGCCTGCGGCGGCTGGCGGAGGAC GAGGCCTTCCAGCGGCGGCGGCTGGAGGAGCAGGCCGCGCAACACAAGGCTGACATCGAG GAGCGCCTGGCCCAGCTGCGCAAGGCATCGGACAGCGAGCTGGAGCGGCAGAAGGGGCTG GTGGAGGACACGCTGAGGCAGCGGCGGCAGGTGGAGGAGGAGATCCTGGCGCTGAAGGCG AGCTTCGAGAAGGCGGCCGCTGGCAAGGCGGAGCTGGAGCTGGAGCTGGGACGCATCCGC AGCAACGCGGAGGACACGCTGCGCAGCAAGGAGCAGGCCGAGCTGGAGGCTGCGAGGCAG CGGCAGCTGGCGGCGGAGGAGGAGCGGCGGCGCCGTGAGGCTGAGGAGCGCGTGCAGAAG AGCCTGGCGGCCGAGGAGGAGGCCGCACGGCAGCGGAAGGCGGCGCTGGAGGAAGTCGAG CGGCTGAAAGCCAAGGTGGAGGAGGCGCGGCGCCTGCGGGAGCGAGCGGAGCAGGAGTCG GCGCGGCAGCTGCAGCTGGCCCAGGAGGCCGCCCAGAAGCGGCTGCAGGCGGAAGAGAAG GCACACGCCTTCGCGGTGCAGCAGAAGGAGCAGGAGCTACAGCAGACGCTGCAGCAGGAG CAGAGCGTGCTGGACCAGCTGCGCGGCGAGGCGGAGGCGGCCCGGCGGGCGGCTGAGGAG GCGGAGGAGGCCCGGGTGCAGGCGGAGCGTGAGGCGGCGCAGTCCCGGCGGCAGGTGGAA GAGGCCGAGCGGCTGAAGCAGTCGGCAGAGGAGCAGGCACAGGCCCGGGCTCAGGCACAG GCGGCTGCAGAGAAGCTGCGCAAGGAGGCCGAGCAAGAGGCGGCGCGGCGGGCACAGGCG GAGCAGGCGGCCCTGCGGCAGAAGCAGGCAGCTGACGCGGAGATGGAGAAGCATAAGAAA TTCGCCGAGCAGACGCTGCGGCAGAAGGCGCAGGTGGAGCAGGAGCTGACAACACTGCGG CTGCAGCTGGAGGAGACCGACCACCAGAAGAACCTGCTGGACGAGGAGCTGCAGCGGCTG AAGGCGGAGGCCACGGAGGCCGCACGCCAGCGCAGCCAGGTGGAGGAGGAGCTCTTCTCG GTGCGCGTGCAGATGGAGGAGCTGAGCAAGCTCAAGGCACGCATCGAGGCTGAGAACCGC GCACTCATCTTGCGTGACAAGGACAATACGCAGCGCTTCCTGCAGGAGGAGGCTGAGAAG ATGAAGCAGGTGGCGGAGGAGGCCGCGCGGCTGAGTGTGGCGGCCCAAGAGGCTGCGCGA CTGCGGCAGCTGGCAGAGGAGGACCTGGCACAGCAGCGGGCCTTGGCAGAGAAGATGCTC AAGGAGAAGATGCAGGCGGTGCAGGAGGCCACGCGACTCAAGGCTGAGGCGGAACTGCTG CAGCAGCAGAAGGAGCTTGCGCAGGAGCAGGCGCGGCGGCTGCAGGAGGACAAGGAGCAG ATGGCGCAGCAGCTGGCGGAGGAGACGCAGGGCTTCCAGCGGACGCTGGAGGCCGAGCGG CAGCGGCAGCTGGAGATGAGCGCTGAGGCTGAGCGCCTCAAGCTGCGTGTGGCCGAGATG AGCCGAGCCCAGGCCCGCGCTGAGGAGGACGCCCAGCGCTTCCGGAAGCAGGCGGAGGAG ATCGGTGAGAAGCTGCACCGCACGGAGCTCGCCACCCAGGAGAAGGTGACCCTGGTGCAG ACACTGGAGATCCAGCGACAGCAGAGTGACCATGATGCCGAGCGCCTGCGGGAGGCCATC GCTGAGCTGGAGCGTGAGAAGGAGAAGCTCCAACAGGAGGCCAAACTGCTGCAGCTCAAG TCTGAGGAGATGCAGACGGTGCAGCAGGAGCAGCTGCTGCAGGAGACGCAGGCCCTGCAG CAAAGCTTCCTCTCTGAAAAGGACAGCCTGCTACAGCGGGAGCGCTTCATCGAGCAGGAG AAGGCCAAGCTGGAGCAGCTCTTCCAGGACGAGGTGGCCAAGGCACAGCAGCTGCGTGAG GAGCAGCAGCGGCAGCAGCAGCAGATGGAGCAGGAACGGCAGCGGCTGGTGGCCAGCATG GAGGAGGCGCGGCGGCGGCAGCATGAGGCCGAGGAGGGCGTGCGGCGCAAGCAGGAGGAG CTGCAGCAGCTGGAGCAGCAGCGGCGGCAGCAGGAGGAGCTGCTGGCTGAGGAGAACCAG AGGCTGCGTGAGCAGCTGCAGCTCCTGGAGGAGCAGCACCGGGCCGCGCTGGCGCACTCA GAGGAGGTCACTGCCTCGCAGGTGGCTGCCACAAAGACCCTGCCCAATGGCCGGGATGCA CTTGATGGCCCCGCGGCAGAGGCAGAGCCGGAGCACAGCTTCGATGGCCTGCGGCGGAAG GTGTCAGCTCAGAGGCTGCAGGAGGCCGGCATCCTGAGTGCGGAGGAGCTGCAGCGGTTG GCGCAGGGCCACACCACGGTGGACGAGCTCGCACGGCGGGAAGACGTGCGCCACTACCTG CAGGGCCGCAGCAGTATCGCAGGGCTGTTGCTGAAGGCCACCAATGAGAAGCTGAGTGTT TACGCCGCCCTGCAGAGGCAGCTGCTGAGTCCCGGCACGGCCCTCATCCTGCTGGAGGCG CAGGCGGCCTCAGGCTTCCTGCTGGACCCTGTGCGGAACCGGCGGCTGACCGTCAACGAG GCTGTGAAGGAGGGTGTGGTGGGCCCCGAGCTGCACCACAAGCTGCTGTCGGCCGAGCGC GCCGTCACTGGCTACAAGGACCCCTACACTGGCCAGCAGATCTCTCTCTTCCAAGCCATG CAGAAGGGCCTCATCGTCCGGGAGCACGGCATCCGCCTGCTGGAGGCCCAGATCGCCACG GGCGGCGTTATCGACCCCGTGCACAGCCACCGCGTGCCCGTGGACGTGGCCTACCGGCGC GGCTACTTCGACGAGGAGATGAACCGCGTCCTGGCGGACCCCAGCGACGACACCAAGGGC TTCTTTGACCCCAACACGCACGAGAACCTCACGTACCTGCAGCTACTGGAGCGCTGCGTG GAGGACCCCGAGACGGGCCTGTGCCTTCTGCCACTCACGGATAAGGCTGCCAAGGGCGGG GAGCTGGTCTACACTGACTCCGAGGCCCGGGACGTCTTTGAGAAGGCCACCGTGTCTGCG CCGTTCGGCAAGTTCCAGGGCAAGACGGTGACCATTTGGGAGATCATCAACTCGGAATAC TTCACGGCAGAGCAGCGGCGGGACCTGCTGCGGCAGTTCCGCACGGGCCGGATCACAGTG GAGAAGATCATCAAGATCATCATCACGGTGGTGGAGGAGCAGGAGCAGAAGGGCCGGCTT TGCTTTGAGGGCCTGCGCAGCCTGGTGCCAGCCGCCGAGCTGCTGGAGAGCAGGGTCATC GACCGCGAGCTCTACCAGCAGCTGCAGCGAGGTGAGCGCTCTGTGCGAGACGTAGCCGAG GTGGACACTGTGCGGCGGGCTCTCCGGGGTGCCAACGTCATCGCGGGTGTATGGCTGGAG GAGGCGGGGCAGAAGCTGAGTATCTACAATGCCCTGAAGAAAGACCTGCTGCCATCCGAC ATGGCCGTGGCCCTGTTGGAAGCCCAGGCCGGCACCGGGCACATCATCGACCCCGCCACC AGCGCCCGGCTGACCGTGGACGAGGCAGTGCGTGCTGGCCTGGTGGGCCCCGAGTTTCAT GAGAAGCTGCTATCAGCCGAGAAGGCTGTGACAGGGTACAGGGACCCCTACACAGGGCAG AGCGTCTCCCTGTTCCAGGCCCTGAAGAAGGGCCTCATTCCCCGGGAGCAGGGCCTGCGC CTGTTGGACGCCCAGCTGTCCACGGGCGGCATCGTGGACCCCAGCAAGAGCCACCGCGTG CCCCTGGATGTCGCCTGCGCCCGAGGCTGCCTGGATGAGGAGACCAGCAGGGCCCTGTCG GCACCAAGGGCCGACGCCAAGGCCTACAGTGACCCCAGCACAGGGGAGCCGGCCACCTAC GGCGAGCTCCAGCAGCGGTGCCGGCCCGACCAGCTGACCGGGCTGAGCCTGCTGCCGCTC TCAGAAAAGGCTGCTCGGGCCCGGCAGGAGGAGCTCTACTCAGAGCTGCAGGCCCGTGAG ACCTTTGAAAAGACCCCGGTTGAGGTCCCCGTGGGTGGCTTCAAGGGCAGGACGGTGACG GTGTGGGAGCTCATCAGCTCTGAGTACTTCACTGCGGAGCAGCGGCAGGAGCTGTTGCGT CAGTTCCGCACGGGCAAGGTCACCGTGGAGAAGGTCATCAAGATTCTCATTACCATCGTG GAGGAGGTGGAGACCCTGCGGCAGGAGAGGCTGTCCTTCAGCGGCCTCCGTGCCCCTGTG CCAGCCAGCGAGCTCCTGGCTTCCGGGGTCCTCAGCAGAGCCCAGTTTGAGCAGCTCAAG GACGGCAAGACGACGGTCAAGGACCTTTCGGAGCTGGGCTCCGTGCGGACGCTGCTGCAG GGCAGTGGCTGCCTCGCCGGCATCTACCTGGAGGACACCAAGGAGAAGGTGTCCATCTAC GAGGCCATGCGCCGGGGCCTGCTGAGAGCCACAACGGCTGCGCTCCTGCTGGAGGCGCAG GCGGCCACTGGCTTCCTGGTGGACCCCGTGCGGAACCAGCGCCTGTATGTCCACGAGGCC GTGAAGGCGGGCGTGGTGGGCCCCGAGCTTCACGAGCAGCTGCTGTCTGCCGAGAAGGCC GTCACCGGCTACAGAGACCCCTACTCGGGCAGCACCATCTCCCTCTTCCAGGCCATGCAG AAGGGCCTGGTTCTCCGGCAGCACGGCATCCGCCTGCTGGAGGCCCAGATCGCCACGGGC GGCATCATCGACCCCGTGCACAGCCACCGCGTGCCTGTGGACGTGGCCTACCAGCGCGGC TACTTCAGTGAGGAGATGAACCGCGTCCTGGCGGACCCCAGCGACGACACCAAGGGCTTC TTTGACCCCAACACGCATGAGAACCTCACGTACAGGCAGCTGCTGGAGCGGTGCGTGGAG GACCCCGAGACGGGCTTGCGCCTTCTGCCACTGAAAGGGGCGGAGAAGGCTGAGGTGGTG GAGACCACGCAGGTGTACACTGAGGAGGAGACAAGAAGGGCATTTGAAGAGACACAGATC GACATTCCCGGCGGCGGCAGCCACGGCGGCTCCACCATGTCCCTGTGGGAGGTGATGCAG TCGGACCTGATCCCCGAGGAGCAGCGGGCCCAGCTGATGGCTGACTTCCAGGCCGGCCGG GTGACCAAGGAACGCATGATCATCATCATCATCGAGATCATTGAGAAGACAGAGATCATC CGCCAGCAGGGTCTGGCCTCCTACGACTACGTGCGCCGCCGCCTCACGGCTGAGGACCTG TTCGAGGCTCGGATCATCTCTCTCGAGACCTACAACCTGCTCCGGGAGGGCACCAGGAGC CTCCGTGAGGCTCTCGAGGCGGAGTCCGCCTGGTGCTACCTCTATGGCACGGGCTCCGTG GCTGGTGTCTACCTGCCCGGTTCCAGGCAGACACTGAGCATCTACCAGGCTCTCAAGAAA GGGCTGCTGAGTGCCGAGGTGGCCCGCCTGCTGCTGGAGGCACAGGCAGCCACAGGCTTC CTGCTGGACCCGGTGAAGGGGGAGCGGCTGACTGTGGATGAGGCTGTGCGGAAGGGCCTC GTGGGGCCCGAGCTGCACGACCGCCTGCTCTCGGCTGAGCGGGCGGTCACCGGCTACCGT GACCCCTACACCGAGCAGACCATCTCGCTCTTCCAGGCCATGAAGAAGGAGCTGATCCCT ACTGAGGAGGCCCTGCGGCTGCTGGATGCCCAGCTGGCCACCGGCGGCATCGTGGACCCC CGCCTGGGCTTCCACCTTCCCCTGGAGGTGGCTTACCAGCGTGGCTACCTCAACAAGGAC ACGCACGACCAGCTGTCAGAGCCCAGCGAGGTGCGCAGCTACGTGGACCCGTCCACCGAC GAGCGCCTCAGCTACACGCAGCTGCTCAGGCGGTGCCGTCGTGACGACGGCACCGGCCAG CTGCTCCTGCCACTGTCGGACGCCCGCAAGCTGACCTTCCGTGGCCTGCGGAAGCAGATC ACCATGGAGGAGCTGGTGCGCTCGCAGGTCATGGACGAGGCCACGGCGCTGCAGCTGCGG GAGGGCCTGACCTCCATCGAGGAGGTCACCAAGAACTTGCAGAAGTTCCTGGAAGGCACC AGCTGCATCGCTGGTGTCTTCGTGGACGCCACCAAGGAACGGCTCTCGGTGTACCAGGCC ATGAAGAAGGGCATCATCCGCCCCGGCACAGCCTTTGAGCTCCTGGAGGCGCAGGCGGCC ACCGGTTACGTCATCGACCCCATCAAGGGACTGAAGCTGACGGTGGAGGAGGCTGTGCGT ATGGGCATTGTGGGCCCCGAGTTCAAGGACAAGCTGCTGTCGGCCGAGCGCGCCGTCACT GGGTACAAGGACCCCTACTCTGGGAAGCTCATCTCCCTCTTCCAGGCCATGAAGAAGGGC CTGATCCTGAAGGACCATGGCATCCGCCTGCTGGAGGCCCAGATCGCCACGGGCGGCATC ATCGACCCTGAGGAGAGCCACCGGCTGCCCGTGGAGGTGGCCTACAAGCGCGGCCTCTTC GATGAGGAGATGAACGAGATCCTGACCGACCCCTCGGACGACACCAAGGGCTTCTTTGAC CCTAACACGGAGGAGAACCTCACCTACCTGCAGCTGATGGAGCGTTGTATCACTGACCCC CAGACGGGCCTGTGTCTCTTGCCGCTGAAGGAGAAGAAGCGGGAGCGGAAGACGTCCTCC AAGTCCTCCGTGCGCAAGCGCCGAGTGGTCATCGTGGACCCCGAGACGGGCAAGGAGATG TCAGTGTACGAGGCCTACCGCAAGGGCCTGATTGACCACCAGACGTACCTGGAGCTGTCC GAGCAGGAGTGCGAGTGGGAGGAGATCACCATCTCCTCCTCGGACGGCGTGGTCAAGTCC ATGATCATCGACCGCCGCTCCGGGCGCCAGTACGACATCGATGATGCCATCGCCAAGAAC CTCATCGACCGCTCGGCACTGGACCAGTACCGCGCCGGCACGCTCTCCATCACCGAGTTC GCCGACATGCTCTCGGGCAACGCCGGTGGTTTCCGCTCCCGTTCCTCCTCGGTGGGATCC TCCTCCTCCTACCCCATCAGCCCCGCCGTCTCCAGGACCCAGCTGGCCTCCTGGTCAGAC CCCACTGAGGAGACGGGCCCCGTGGCTGGCATCCTGGACACGGAGACGCTGGAGAAGGTG TCCATCACCGAGGCCATGCACCGGAACCTGGTGGATAACATCACGGGGCAGCGGCTGCTG GAGGCGCAGGCCTGCACCGGGGGCATCATCGACCCCAGCACCGGTGAGCGCTTCCCTGTC ACCGACGCCGTCAACAAGGGCCTGGTGGACAAGATCATGGTGGACCGCATCAACCTGGCC CAGAAGGCCTTCTGCGGCTTCGAGGACCCACGCACCAAGACCAAGATGTCGGCCGCCCAG GCCCTGAAGAAGGGCTGGCTCTACTACGAGGCCGGCCAGCGCTTCCTGGAGGTGCAGTAC CTGACCGGCGGCTTGATCGAGCCCGACACGCCGGGCCGCGTGCCCCTGGACGAGGCCCTG CAGCGCGGCACGGTGGACGCCCGCACCGCACAGAAGCTGCGTGACGTGGGCGCCTACTCC AAGTACCTCACCTGCCCTAAGACCAAGCTCAAGATCTCCTATAAGGACGCGCTGGACCGC AGCATGGTGGAGGAGGGCACGGGGCTGCGGCTGCTGGAGGCTGCCGCGCAGTCCACCAAG GGCTACTACAGCCCCTACAGCGTCAGCGGCTCCGGCTCTACCGCTGGCTCCCGCACCGGC TCGCGCACCGGCTCCCGGGCCGGCTCCCGCCGCGGCAGCTTTGACGCCACCGGCTCCGGC TTCTCCATGACCTTCTCTTCATCCTCCTACTCCTCCTCGGGCTACGGCCGCCGCTACGCC TCGGGGTCCTCGGCCTCCCTGGGGGGCCCTGAGTCTGCCGTGGCCTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_201381 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_201381.1, NP_958783.1 |
| RefSeq Size | 14646 bp |
| RefSeq ORF | 13548 bp |
| Locus ID | 5339 |
| UniProt ID | Q15149 |
| Protein Families | Druggable Genome |
| Gene Summary | Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011] Transcript Variant: This variant (7) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1d) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1d has been found associated with Z-disks in skeletal muscle (PMID: 17389230). |
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