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Plectin (PLEC) (NM_201379) Human Untagged Clone
CAT＃: SC308014
PLEC (untagged)-Human plectin (PLEC), transcript variant 3
CNY 87,120.00
货期*
详询
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | EBS1; EBSMD; EBSND; EBSO; EBSOG; EBSPA; HD1; LGMD2Q; LGMDR17; PCN; PLEC1; PLEC1b; PLTN |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_201379, the custom clone sequence may differ by one or more nucleotides
ATGGACCCCTCGCGAGCCATCCAGAACGAGATCAGCTCCCTCAAAGATGAGCGGGATCGT GTGCAGAAGAAAACCTTCACCAAGTGGGTCAACAAGCACCTCATCAAGGCCCAGAGGCAC ATCAGTGACCTGTATGAAGACCTCCGCGATGGCCACAACCTCATCTCCCTGCTGGAGGTC CTCTCGGGGGACAGCCTGCCCCGGGAGAAGGGGAGGATGCGTTTCCACAAGCTGCAGAAT GTCCAGATTGCCCTGGACTACCTCCGGCACCGCCAGGTGAAGCTGGTGAACATCAGGAAT GATGACATCGCTGACGGCAACCCCAAGCTGACCCTTGGCCTCATCTGGACAATCATTCTG CACTTCCAGATCTCAGATATCCAGGTGAGTGGGCAGTCGGAGGACATGACGGCCAAGGAG AAGCTGCTGCTGTGGTCGCAGCGAATGGTGGAGGGGTACCAGGGCCTGCGATGCGACAAC TTCACCTCCAGCTGGAGAGACGGCCGCCTCTTCAATGCCATCATCCACCGGCACAAGCCC CTGCTCATCGACATGAACAAGGTGTACCGGCAGACCAACCTGGAGAACCTGGACCAGGCC TTCTCTGTGGCGGAGCGGGACCTGGGAGTGACGCGGCTCCTGGACCCTGAGGACGTGGAT GTCCCTCAGCCCGACGAGAAGTCCATCATCACCTACGTCTCGTCGCTGTATGACGCCATG CCCCGCGTGCCGGACGTGCAGGATGGGGTGAGGGCCAACGAGCTGCAGCTGCGCTGGCAG GAGTACCGGGAGCTGGTGCTGCTGCTGCTTCAGTGGATGCGACACCACACGGCCGCCTTT GAGGAACGCAGGTTCCCCTCCAGCTTCGAGGAGATTGAGATCCTGTGGTCTCAGTTCCTG AAGTTTAAGGAGATGGAGCTACCAGCCAAGGAGGCCGACAAGAACAGGTCCAAGGGCATC TACCAATCCCTGGAGGGAGCGGTGCAAGCAGGCCAGCTCAAGGTGCCCCCTGGCTACCAC CCGCTGGATGTGGAGAAGGAGTGGGGCAAGCTGCACGTGGCCATCCTGGAGCGGGAGAAG CAGCTCCGCAGCGAGTTTGAGAGGCTGGAGTGTCTTCAGCGCATCGTGACCAAGCTGCAG ATGGAGGCGGGGCTGTGTGAGGAGCAGCTGAACCAGGCCGACGCCCTGCTGCAGTCGGAT GTCCGGCTGCTGGCTGCAGGCAAAGTGCCACAGCGGGCGGGGGAGGTGGAACGGGACTTG GACAAGGCGGATAGCATGATCCGGCTGCTCTTCAACGACGTGCAGACCCTCAAGGATGGA CGGCACCCGCAGGGCGAGCAGATGTACCGCAGGGTGTACCGTCTGCACGAGCGCCTGGTA GCCATCCGCACCGAGTACAACCTACGGCTGAAGGCAGGCGTGGCGGCCCCTGCAACCCAG GTGGCCCAGGTGACTCTGCAGAGTGTGCAGAGGCGCCCCGAGCTGGAGGACTCCACTCTG CGCTACCTGCAGGACCTGCTGGCCTGGGTGGAGGAGAACCAGCACCGTGTGGATGGCGCT GAGTGGGGTGTGGACCTGCCCAGCGTGGAGGCGCAGCTGGGCAGCCACCGAGGCCTGCAC CAGTCCATCGAAGAATTCCGGGCCAAGATCGAGCGGGCACGGAGTGACGAGGGCCAGCTC TCCCCCGCCACCCGGGGTGCCTACCGTGACTGCCTGGGTCGGCTGGACCTGCAGTACGCC AAGCTGCTGAACTCCTCCAAGGCCCGCCTCAGGTCCCTGGAGAGCTTGCACAGCTTTGTG GCAGCCGCCACTAAGGAGCTAATGTGGCTGAATGAGAAGGAGGAGGAGGAGGTGGGCTTC GACTGGAGCGACCGCAACACCAACATGACCGCCAAGAAGGAGAGCTACTCGGCGCTGATG CGGGAGCTGGAGCTGAAGGAGAAGAAGATCAAGGAGCTCCAAAATGCTGGGGACCGGCTG CTGCGGGAGGACCACCCGGCCCGGCCCACGGTGGAGTCCTTCCAGGCGGCCCTGCAGACG CAGTGGAGCTGGATGCTACAGCTGTGCTGCTGTATCGAGGCACACCTGAAGGAGAACGCT GCCTACTTTCAGTTCTTCTCAGATGTGCGGGAGGCCGAGGGGCAGTTGCAGAAGCTGCAG GAGGCACTGCGTAGGAAATACAGTTGTGATCGCTCCGCCACCGTCACCCGGCTGGAGGAC CTGCTGCAGGATGCCCAGGACGAGAAGGAACAGCTGAACGAGTACAAGGGCCACCTCTCA GGCCTGGCCAAGCGGGCCAAGGCCGTCGTGCAGCTGAAGCCCCGCCACCCAGCCCACCCC ATGCGGGGCCGCCTGCCCCTGCTGGCCGTGTGCGACTATAAGCAGGTGGAGGTGACTGTG CACAAGGGTGACGAGTGCCAGCTGGTGGGCCCTGCACAGCCGTCCCACTGGAAGGTGCTC AGCAGCTCCGGCAGCGAGGCCGCCGTGCCCTCCGTGTGCTTCCTGGTGCCCCCGCCCAAC CAGGAGGCCCAGGAGGCCGTCACCAGGCTGGAGGCCCAGCACCAGGCCCTGGTCACGCTG TGGCACCAGTTGCACGTGGACATGAAGAGCCTTCTGGCCTGGCAGAGCCTTCGCCGCGAC GTGCAGCTCATCCGCTCCTGGTCCCTGGCCACGTTCCGCACCCTGAAGCCAGAGGAGCAG CGCCAAGCCCTGCACAGCCTGGAGCTGCACTACCAGGCCTTCCTGCGGGACAGCCAGGAC GCGGGCGGCTTCGGACCCGAGGACCGGCTGATGGCTGAGCGCGAGTACGGCTCCTGCAGC CACCACTACCAGCAGCTGCTGCAGAGCCTGGAACAGGGTGCACAGGAAGAGTCTCGCTGC CAGCGCTGCATCTCCGAGCTCAAAGACATCCGGCTGCAGCTGGAGGCCTGTGAGACGCGC ACCGTGCACCGCCTGCGGCTGCCGCTGGACAAAGAGCCGGCACGGGAGTGTGCCCAGCGC ATCGCCGAGCAGCAGAAGGCACAGGCAGAGGTGGAGGGGCTGGGCAAGGGGGTCGCCCGG CTCTCTGCCGAGGCCGAGAAGGTCTTGGCCCTACCAGAGCCATCGCCTGCGGCCCCCACG CTGCGCTCGGAGCTGGAGCTGACGCTGGGCAAGCTGGAGCAGGTCCGCAGCCTGTCTGCC ATCTACCTGGAGAAGCTCAAGACCATCAGCCTGGTGATCCGCGGCACGCAGGGGGCCGAG GAGGTGCTCAGGGCCCACGAGGAGCAGCTCAAGGAGGCCCAGGCCGTGCCGGCCACCCTC CCGGAGCTCGAGGCCACCAAGGCCTCTCTGAAGAAGCTGCGGGCCCAGGCCGAGGCACAG CAGCCCACGTTCGACGCCCTGCGGGATGAGCTGCGGGGGGCACAGGAGGTGGGGGAGCGA CTGCAGCAGCGGCACGGGGAGCGGGACGTGGAGGTGGAGCGCTGGCGGGAGCGGGTCGCC CAGTTGCTTGAGCGCTGGCAGGCTGTGCTGGCCCAGACCGACGTGCGGCAGCGCGAGCTC GAGCAACTGGGCCGCCAGCTGCGTTACTACCGCGAGAGTGCAGACCCCTTGGGCGCCTGG CTGCAGGACGCCAGGCGGCGGCAGGAGCAGATCCAGGCCATGCCGCTGGCCGACAGCCAG GCTGTGCGGGAGCAGCTGCGGCAGGAGCAGGCCCTGCTGGAGGAGATCGAGCGCCACGGC GAGAAGGTCGAGGAGTGCCAGAGGTTTGCGAAACAGTACATCAACGCCATCAAGGACTAT GAACTCCAGCTGGTGACGTACAAGGCGCAGCTTGAGCCGGTGGCCTCCCCGGCCAAGAAG CCCAAGGTCCAGTCGGGATCAGAGAGTGTCATCCAGGAGTACGTGGACCTGCGTACGCAC TACAGCGAGCTGACCACACTGACGAGCCAGTACATCAAGTTCATCAGCGAGACTCTGCGG CGCATGGAGGAGGAGGAGAGGCTGGCTGAGCAGCAGCGGGCAGAGGAGCGCGAGCGGCTG GCCGAGGTGGAGGCCGCGCTGGAGAAGCAGCGGCAGCTGGCCGAGGCGCACGCCCAGGCA AAGGCACAGGCGGAGCGGGAGGCGAAGGAGCTGCAGCAGCGCATGCAGGAGGAGGTGGTG CGGCGGGAGGAGGCGGCGGTGGACGCGCAGCAGCAGAAGCGCAGCATTCAGGAGGAGCTG CAGCAGCTGCGGCAGAGCTCGGAGGCGGAGATCCAGGCCAAGGCCCGGCAGGCAGAGGCG GCTGAGCGCAGCCGGCTGCGCATCGAGGAGGAGATCCGCGTGGTGCGCCTGCAGTTGGAG GCCACCGAGCGCCAGCGTGGCGGGGCTGAGGGGGAGCTGCAGGCACTGCGTGCACGGGCG GAGGAGGCTGAGGCACAAAAGCGACAGGCGCAGGAGGAGGCCGAGCGCTTGCGGAGGCAG GTGCAGGACGAGAGCCAGCGTAAGCGGCAGGCGGAGGTGGAGCTGGCCTCGCGCGTGAAG GCCGAGGCCGAGGCGGCGCGCGAGAAGCAGCGGGCCCTGCAGGCCCTGGAGGAGCTGCGG CTGCAGGCGGAGGAGGCGGAGCGGCGCCTGCGGCAGGCCGAGGTGGAGCGAGCGCGGCAG GTACAGGTGGCCCTGGAGACGGCGCAGCGCAGTGCAGAGGCGGAGCTGCAGAGCAAACGC GCCTCCTTCGCCGAGAAGACGGCACAGCTGGAGCGCTCCCTGCAGGAGGAACACGTGGCT GTGGCACAGCTGCGGGAGGAGGCTGAGCGGCGGGCACAGCAGCAGGCCGAGGCCGAGCGG GCGCGCGAGGAGGCAGAGCGGGAGCTGGAGCGCTGGCAGCTCAAGGCCAACGAGGCGCTA CGGCTGCGGCTGCAGGCGGAGGAGGTGGCGCAGCAGAAGAGCCTGGCGCAGGCCGAGGCT GAGAAGCAGAAGGAGGAGGCGGAGCGCGAGGCGCGGCGGCGCGGCAAGGCGGAGGAGCAG GCCGTCCGGCAGCGGGAGCTGGCTGAACAAGAGCTGGAGAAGCAGCGGCAGCTGGCGGAA GGCACCGCGCAGCAGCGCCTGGCCGCGGAGCAGGAGTTGATCCGGCTGCGGGCCGAGACG GAGCAGGGGGAGCAGCAGCGGCAGCTGCTGGAGGAGGAGCTGGCCCGGCTGCAGCGTGAG GCGGCTGCAGCCACGCAGAAACGGCAGGAGCTGGAAGCCGAGCTGGCCAAGGTGCGGGCC GAGATGGAGGTGCTGCTGGCCAGCAAGGCGAGGGCTGAGGAGGAGTCGCGCTCCACCAGC GAGAAGTCCAAGCAGAGGCTGGAGGCCGAGGCCGGCCGGTTCCGCGAGCTGGCCGAGGAG GCCGCCCGCCTGCGTGCCCTGGCGGAAGAGGCCAAGCGGCAGCGGCAGCTGGCCGAGGAA GACGCGGCGCGGCAGCGGGCCGAGGCGGAGCGGGTGCTTGCGGAGAAGCTGGCCGCCATC GGCGAGGCCACGCGGCTCAAGACGGAGGCGGAGATCGCGCTCAAGGAGAAGGAGGCGGAG AACGAGCGCCTGCGGCGGCTGGCGGAGGACGAGGCCTTCCAGCGGCGGCGGCTGGAGGAG CAGGCCGCGCAACACAAGGCTGACATCGAGGAGCGCCTGGCCCAGCTGCGCAAGGCATCG GACAGCGAGCTGGAGCGGCAGAAGGGGCTGGTGGAGGACACGCTGAGGCAGCGGCGGCAG GTGGAGGAGGAGATCCTGGCGCTGAAGGCGAGCTTCGAGAAGGCGGCCGCTGGCAAGGCG GAGCTGGAGCTGGAGCTGGGACGCATCCGCAGCAACGCGGAGGACACGCTGCGCAGCAAG GAGCAGGCCGAGCTGGAGGCTGCGAGGCAGCGGCAGCTGGCGGCGGAGGAGGAGCGGCGG CGCCGTGAGGCTGAGGAGCGCGTGCAGAAGAGCCTGGCGGCCGAGGAGGAGGCCGCACGG CAGCGGAAGGCGGCGCTGGAGGAAGTCGAGCGGCTGAAAGCCAAGGTGGAGGAGGCGCGG CGCCTGCGGGAGCGAGCGGAGCAGGAGTCGGCGCGGCAGCTGCAGCTGGCCCAGGAGGCC GCCCAGAAGCGGCTGCAGGCGGAAGAGAAGGCACACGCCTTCGCGGTGCAGCAGAAGGAG CAGGAGCTACAGCAGACGCTGCAGCAGGAGCAGAGCGTGCTGGACCAGCTGCGCGGCGAG GCGGAGGCGGCCCGGCGGGCGGCTGAGGAGGCGGAGGAGGCCCGGGTGCAGGCGGAGCGT GAGGCGGCGCAGTCCCGGCGGCAGGTGGAAGAGGCCGAGCGGCTGAAGCAGTCGGCAGAG GAGCAGGCACAGGCCCGGGCTCAGGCACAGGCGGCTGCAGAGAAGCTGCGCAAGGAGGCC GAGCAAGAGGCGGCGCGGCGGGCACAGGCGGAGCAGGCGGCCCTGCGGCAGAAGCAGGCA GCTGACGCGGAGATGGAGAAGCATAAGAAATTCGCCGAGCAGACGCTGCGGCAGAAGGCG CAGGTGGAGCAGGAGCTGACAACACTGCGGCTGCAGCTGGAGGAGACCGACCACCAGAAG AACCTGCTGGACGAGGAGCTGCAGCGGCTGAAGGCGGAGGCCACGGAGGCCGCACGCCAG CGCAGCCAGGTGGAGGAGGAGCTCTTCTCGGTGCGCGTGCAGATGGAGGAGCTGAGCAAG CTCAAGGCACGCATCGAGGCTGAGAACCGCGCACTCATCTTGCGTGACAAGGACAATACG CAGCGCTTCCTGCAGGAGGAGGCTGAGAAGATGAAGCAGGTGGCGGAGGAGGCCGCGCGG CTGAGTGTGGCGGCCCAAGAGGCTGCGCGACTGCGGCAGCTGGCAGAGGAGGACCTGGCA CAGCAGCGGGCCTTGGCAGAGAAGATGCTCAAGGAGAAGATGCAGGCGGTGCAGGAGGCC ACGCGACTCAAGGCTGAGGCGGAACTGCTGCAGCAGCAGAAGGAGCTTGCGCAGGAGCAG GCGCGGCGGCTGCAGGAGGACAAGGAGCAGATGGCGCAGCAGCTGGCGGAGGAGACGCAG GGCTTCCAGCGGACGCTGGAGGCCGAGCGGCAGCGGCAGCTGGAGATGAGCGCTGAGGCT GAGCGCCTCAAGCTGCGTGTGGCCGAGATGAGCCGAGCCCAGGCCCGCGCTGAGGAGGAC GCCCAGCGCTTCCGGAAGCAGGCGGAGGAGATCGGTGAGAAGCTGCACCGCACGGAGCTC GCCACCCAGGAGAAGGTGACCCTGGTGCAGACACTGGAGATCCAGCGACAGCAGAGTGAC CATGATGCCGAGCGCCTGCGGGAGGCCATCGCTGAGCTGGAGCGTGAGAAGGAGAAGCTC CAACAGGAGGCCAAACTGCTGCAGCTCAAGTCTGAGGAGATGCAGACGGTGCAGCAGGAG CAGCTGCTGCAGGAGACGCAGGCCCTGCAGCAAAGCTTCCTCTCTGAAAAGGACAGCCTG CTACAGCGGGAGCGCTTCATCGAGCAGGAGAAGGCCAAGCTGGAGCAGCTCTTCCAGGAC GAGGTGGCCAAGGCACAGCAGCTGCGTGAGGAGCAGCAGCGGCAGCAGCAGCAGATGGAG CAGGAACGGCAGCGGCTGGTGGCCAGCATGGAGGAGGCGCGGCGGCGGCAGCATGAGGCC GAGGAGGGCGTGCGGCGCAAGCAGGAGGAGCTGCAGCAGCTGGAGCAGCAGCGGCGGCAG CAGGAGGAGCTGCTGGCTGAGGAGAACCAGAGGCTGCGTGAGCAGCTGCAGCTCCTGGAG GAGCAGCACCGGGCCGCGCTGGCGCACTCAGAGGAGGTCACTGCCTCGCAGGTGGCTGCC ACAAAGACCCTGCCCAATGGCCGGGATGCACTTGATGGCCCCGCGGCAGAGGCAGAGCCG GAGCACAGCTTCGATGGCCTGCGGCGGAAGGTGTCAGCTCAGAGGCTGCAGGAGGCCGGC ATCCTGAGTGCGGAGGAGCTGCAGCGGTTGGCGCAGGGCCACACCACGGTGGACGAGCTC GCACGGCGGGAAGACGTGCGCCACTACCTGCAGGGCCGCAGCAGTATCGCAGGGCTGTTG CTGAAGGCCACCAATGAGAAGCTGAGTGTTTACGCCGCCCTGCAGAGGCAGCTGCTGAGT CCCGGCACGGCCCTCATCCTGCTGGAGGCGCAGGCGGCCTCAGGCTTCCTGCTGGACCCT GTGCGGAACCGGCGGCTGACCGTCAACGAGGCTGTGAAGGAGGGTGTGGTGGGCCCCGAG CTGCACCACAAGCTGCTGTCGGCCGAGCGCGCCGTCACTGGCTACAAGGACCCCTACACT GGCCAGCAGATCTCTCTCTTCCAAGCCATGCAGAAGGGCCTCATCGTCCGGGAGCACGGC ATCCGCCTGCTGGAGGCCCAGATCGCCACGGGCGGCGTTATCGACCCCGTGCACAGCCAC CGCGTGCCCGTGGACGTGGCCTACCGGCGCGGCTACTTCGACGAGGAGATGAACCGCGTC CTGGCGGACCCCAGCGACGACACCAAGGGCTTCTTTGACCCCAACACGCACGAGAACCTC ACGTACCTGCAGCTACTGGAGCGCTGCGTGGAGGACCCCGAGACGGGCCTGTGCCTTCTG CCACTCACGGATAAGGCTGCCAAGGGCGGGGAGCTGGTCTACACTGACTCCGAGGCCCGG GACGTCTTTGAGAAGGCCACCGTGTCTGCGCCGTTCGGCAAGTTCCAGGGCAAGACGGTG ACCATTTGGGAGATCATCAACTCGGAATACTTCACGGCAGAGCAGCGGCGGGACCTGCTG CGGCAGTTCCGCACGGGCCGGATCACAGTGGAGAAGATCATCAAGATCATCATCACGGTG GTGGAGGAGCAGGAGCAGAAGGGCCGGCTTTGCTTTGAGGGCCTGCGCAGCCTGGTGCCA GCCGCCGAGCTGCTGGAGAGCAGGGTCATCGACCGCGAGCTCTACCAGCAGCTGCAGCGA GGTGAGCGCTCTGTGCGAGACGTAGCCGAGGTGGACACTGTGCGGCGGGCTCTCCGGGGT GCCAACGTCATCGCGGGTGTATGGCTGGAGGAGGCGGGGCAGAAGCTGAGTATCTACAAT GCCCTGAAGAAAGACCTGCTGCCATCCGACATGGCCGTGGCCCTGTTGGAAGCCCAGGCC GGCACCGGGCACATCATCGACCCCGCCACCAGCGCCCGGCTGACCGTGGACGAGGCAGTG CGTGCTGGCCTGGTGGGCCCCGAGTTTCATGAGAAGCTGCTATCAGCCGAGAAGGCTGTG ACAGGGTACAGGGACCCCTACACAGGGCAGAGCGTCTCCCTGTTCCAGGCCCTGAAGAAG GGCCTCATTCCCCGGGAGCAGGGCCTGCGCCTGTTGGACGCCCAGCTGTCCACGGGCGGC ATCGTGGACCCCAGCAAGAGCCACCGCGTGCCCCTGGATGTCGCCTGCGCCCGAGGCTGC CTGGATGAGGAGACCAGCAGGGCCCTGTCGGCACCAAGGGCCGACGCCAAGGCCTACAGT GACCCCAGCACAGGGGAGCCGGCCACCTACGGCGAGCTCCAGCAGCGGTGCCGGCCCGAC CAGCTGACCGGGCTGAGCCTGCTGCCGCTCTCAGAAAAGGCTGCTCGGGCCCGGCAGGAG GAGCTCTACTCAGAGCTGCAGGCCCGTGAGACCTTTGAAAAGACCCCGGTTGAGGTCCCC GTGGGTGGCTTCAAGGGCAGGACGGTGACGGTGTGGGAGCTCATCAGCTCTGAGTACTTC ACTGCGGAGCAGCGGCAGGAGCTGTTGCGTCAGTTCCGCACGGGCAAGGTCACCGTGGAG AAGGTCATCAAGATTCTCATTACCATCGTGGAGGAGGTGGAGACCCTGCGGCAGGAGAGG CTGTCCTTCAGCGGCCTCCGTGCCCCTGTGCCAGCCAGCGAGCTCCTGGCTTCCGGGGTC CTCAGCAGAGCCCAGTTTGAGCAGCTCAAGGACGGCAAGACGACGGTCAAGGACCTTTCG GAGCTGGGCTCCGTGCGGACGCTGCTGCAGGGCAGTGGCTGCCTCGCCGGCATCTACCTG GAGGACACCAAGGAGAAGGTGTCCATCTACGAGGCCATGCGCCGGGGCCTGCTGAGAGCC ACAACGGCTGCGCTCCTGCTGGAGGCGCAGGCGGCCACTGGCTTCCTGGTGGACCCCGTG CGGAACCAGCGCCTGTATGTCCACGAGGCCGTGAAGGCGGGCGTGGTGGGCCCCGAGCTT CACGAGCAGCTGCTGTCTGCCGAGAAGGCCGTCACCGGCTACAGAGACCCCTACTCGGGC AGCACCATCTCCCTCTTCCAGGCCATGCAGAAGGGCCTGGTTCTCCGGCAGCACGGCATC CGCCTGCTGGAGGCCCAGATCGCCACGGGCGGCATCATCGACCCCGTGCACAGCCACCGC GTGCCTGTGGACGTGGCCTACCAGCGCGGCTACTTCAGTGAGGAGATGAACCGCGTCCTG GCGGACCCCAGCGACGACACCAAGGGCTTCTTTGACCCCAACACGCATGAGAACCTCACG TACAGGCAGCTGCTGGAGCGGTGCGTGGAGGACCCCGAGACGGGCTTGCGCCTTCTGCCA CTGAAAGGGGCGGAGAAGGCTGAGGTGGTGGAGACCACGCAGGTGTACACTGAGGAGGAG ACAAGAAGGGCATTTGAAGAGACACAGATCGACATTCCCGGCGGCGGCAGCCACGGCGGC TCCACCATGTCCCTGTGGGAGGTGATGCAGTCGGACCTGATCCCCGAGGAGCAGCGGGCC CAGCTGATGGCTGACTTCCAGGCCGGCCGGGTGACCAAGGAACGCATGATCATCATCATC ATCGAGATCATTGAGAAGACAGAGATCATCCGCCAGCAGGGTCTGGCCTCCTACGACTAC GTGCGCCGCCGCCTCACGGCTGAGGACCTGTTCGAGGCTCGGATCATCTCTCTCGAGACC TACAACCTGCTCCGGGAGGGCACCAGGAGCCTCCGTGAGGCTCTCGAGGCGGAGTCCGCC TGGTGCTACCTCTATGGCACGGGCTCCGTGGCTGGTGTCTACCTGCCCGGTTCCAGGCAG ACACTGAGCATCTACCAGGCTCTCAAGAAAGGGCTGCTGAGTGCCGAGGTGGCCCGCCTG CTGCTGGAGGCACAGGCAGCCACAGGCTTCCTGCTGGACCCGGTGAAGGGGGAGCGGCTG ACTGTGGATGAGGCTGTGCGGAAGGGCCTCGTGGGGCCCGAGCTGCACGACCGCCTGCTC TCGGCTGAGCGGGCGGTCACCGGCTACCGTGACCCCTACACCGAGCAGACCATCTCGCTC TTCCAGGCCATGAAGAAGGAGCTGATCCCTACTGAGGAGGCCCTGCGGCTGCTGGATGCC CAGCTGGCCACCGGCGGCATCGTGGACCCCCGCCTGGGCTTCCACCTTCCCCTGGAGGTG GCTTACCAGCGTGGCTACCTCAACAAGGACACGCACGACCAGCTGTCAGAGCCCAGCGAG GTGCGCAGCTACGTGGACCCGTCCACCGACGAGCGCCTCAGCTACACGCAGCTGCTCAGG CGGTGCCGTCGTGACGACGGCACCGGCCAGCTGCTCCTGCCACTGTCGGACGCCCGCAAG CTGACCTTCCGTGGCCTGCGGAAGCAGATCACCATGGAGGAGCTGGTGCGCTCGCAGGTC ATGGACGAGGCCACGGCGCTGCAGCTGCGGGAGGGCCTGACCTCCATCGAGGAGGTCACC AAGAACTTGCAGAAGTTCCTGGAAGGCACCAGCTGCATCGCTGGTGTCTTCGTGGACGCC ACCAAGGAACGGCTCTCGGTGTACCAGGCCATGAAGAAGGGCATCATCCGCCCCGGCACA GCCTTTGAGCTCCTGGAGGCGCAGGCGGCCACCGGTTACGTCATCGACCCCATCAAGGGA CTGAAGCTGACGGTGGAGGAGGCTGTGCGTATGGGCATTGTGGGCCCCGAGTTCAAGGAC AAGCTGCTGTCGGCCGAGCGCGCCGTCACTGGGTACAAGGACCCCTACTCTGGGAAGCTC ATCTCCCTCTTCCAGGCCATGAAGAAGGGCCTGATCCTGAAGGACCATGGCATCCGCCTG CTGGAGGCCCAGATCGCCACGGGCGGCATCATCGACCCTGAGGAGAGCCACCGGCTGCCC GTGGAGGTGGCCTACAAGCGCGGCCTCTTCGATGAGGAGATGAACGAGATCCTGACCGAC CCCTCGGACGACACCAAGGGCTTCTTTGACCCTAACACGGAGGAGAACCTCACCTACCTG CAGCTGATGGAGCGTTGTATCACTGACCCCCAGACGGGCCTGTGTCTCTTGCCGCTGAAG GAGAAGAAGCGGGAGCGGAAGACGTCCTCCAAGTCCTCCGTGCGCAAGCGCCGAGTGGTC ATCGTGGACCCCGAGACGGGCAAGGAGATGTCAGTGTACGAGGCCTACCGCAAGGGCCTG ATTGACCACCAGACGTACCTGGAGCTGTCCGAGCAGGAGTGCGAGTGGGAGGAGATCACC ATCTCCTCCTCGGACGGCGTGGTCAAGTCCATGATCATCGACCGCCGCTCCGGGCGCCAG TACGACATCGATGATGCCATCGCCAAGAACCTCATCGACCGCTCGGCACTGGACCAGTAC CGCGCCGGCACGCTCTCCATCACCGAGTTCGCCGACATGCTCTCGGGCAACGCCGGTGGT TTCCGCTCCCGTTCCTCCTCGGTGGGATCCTCCTCCTCCTACCCCATCAGCCCCGCCGTC TCCAGGACCCAGCTGGCCTCCTGGTCAGACCCCACTGAGGAGACGGGCCCCGTGGCTGGC ATCCTGGACACGGAGACGCTGGAGAAGGTGTCCATCACCGAGGCCATGCACCGGAACCTG GTGGATAACATCACGGGGCAGCGGCTGCTGGAGGCGCAGGCCTGCACCGGGGGCATCATC GACCCCAGCACCGGTGAGCGCTTCCCTGTCACCGACGCCGTCAACAAGGGCCTGGTGGAC AAGATCATGGTGGACCGCATCAACCTGGCCCAGAAGGCCTTCTGCGGCTTCGAGGACCCA CGCACCAAGACCAAGATGTCGGCCGCCCAGGCCCTGAAGAAGGGCTGGCTCTACTACGAG GCCGGCCAGCGCTTCCTGGAGGTGCAGTACCTGACCGGCGGCTTGATCGAGCCCGACACG CCGGGCCGCGTGCCCCTGGACGAGGCCCTGCAGCGCGGCACGGTGGACGCCCGCACCGCA CAGAAGCTGCGTGACGTGGGCGCCTACTCCAAGTACCTCACCTGCCCTAAGACCAAGCTC AAGATCTCCTATAAGGACGCGCTGGACCGCAGCATGGTGGAGGAGGGCACGGGGCTGCGG CTGCTGGAGGCTGCCGCGCAGTCCACCAAGGGCTACTACAGCCCCTACAGCGTCAGCGGC TCCGGCTCTACCGCTGGCTCCCGCACCGGCTCGCGCACCGGCTCCCGGGCCGGCTCCCGC CGCGGCAGCTTTGACGCCACCGGCTCCGGCTTCTCCATGACCTTCTCTTCATCCTCCTAC TCCTCCTCGGGCTACGGCCGCCGCTACGCCTCGGGGTCCTCGGCCTCCCTGGGGGGCCCT GAGTCTGCCGTGGCCTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_201379 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_201379.1, NP_958781.1 |
| RefSeq Size | 14751 bp |
| RefSeq ORF | 13578 bp |
| Locus ID | 5339 |
| UniProt ID | Q15149 |
| Protein Families | Druggable Genome |
| Gene Summary | Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011] Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1e) contains a distinct N-terminus compared to isoform 1c. |
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