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RANKL (TNFSF11) (NM_033012) Human Untagged Clone
CAT＃: SC305532
TNFSF11 (untagged)-Human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2
CNY 2,400.00
CNY 3,990.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_033012 edited
CGCCTGGCCTATTGAAGGTTTTTAATCTTCAGAGTTTCGACTTTATCAACAACACTTAGA AGCCACCAAAGAATTGCAGATGGATCCTAATAGAATATCAGAAGATGGCACTCACTGCAT TTATAGAATTTTGAGACTCCATGAAAATGCAGATTTTCAAGACACAACTCTGGAGAGTCA AGATACAAAATTAATACCTGATTCATGTAGGAGAATTAAACAGGCCTTTCAAGGAGCTGT GCAAAAGGAATTACAACATATCGTTGGATCACAGCACATCAGAGCAGAGAAAGCGATGGT GGATGGCTCATGGTTAGATCTGGCCAAGAGGAGCAAGCTTGAAGCTCAGCCTTTTGCTCA TCTCACTATTAATGCCACCGACATCCCATCTGGTTCCCATAAAGTGAGTCTGTCCTCTTG GTACCATGATCGGGGTTGGGCCAAGATCTCCAACATGACTTTTAGCAATGGAAAACTAAT AGTTAATCAGGATGGCTTTTATTACCTGTATGCCAACATTTGCTTTCGACATCATGAAAC TTCAGGAGACCTAGCTACAGAGTATCTTCAACTAATGGTGTACGTCACTAAAACCAGCAT CAAAATCCCAAGTTCTCATACCCTGATGAAAGGAGGAAGCACCAAGTATTGGTCAGGGAA TTCTGAATTCCATTTTTATTCCATAAACGTTGGTGGATTTTTTAAGTTACGGTCTGGAGA GGAAATCAGCATCGAGGTCTCCAACCCCTCCTTACTGGATCCGGATCAGGATGCAACATA CTTTGGGGCTTTTAAAGTTCGAGATATAGATTGAGCCCCAGTTTTTGGAGT >OriGene 5' read for NM_033012 unedited
CAGTTCACATTTGTATACGACTCATATAGGGCGGCCGCGATTCAAATCTGGTACCGAGCT CGGATCCACTAGTAACGGCCGCCAGTGTGCTGGAATTCGCCCTTCGCCTGGCCTATTGAA GGTTTTTAATCTTCAGAGTTTCGACTTTATCAACAACACTTAGAAGCCACCAAAGAATTG CAGATGGATCCTAATAGAATATCAGAAGATGGCACTCACTGCATTTATAGAATTTTGAGA CTCCATGAAAATGCAGATTTTCAAGACACAACTCTGGAGAGTCAAGATACAAAATTAATA CCTGATTCATGTAGGAGAATTAAACAGGCCTTTCAAGGAGCTGTGCAAAAGGAATTACAA CATATCGTTGGATCACAGCACATCAGAGCAGAGAAAGCGATGGTGGATGGCTCATGGTTA GATCTGGCCAAGAGGAGCAAGCTTGAAGCTCAGCCTTTTGCTCATCTCACTATTAATGCC ACCGACATCCCATCTGGTTCCCATAAAGTGAGTCTGTCCTCTTGGTACCATGATCGGGGT TGGGCCAAGATCTCCAACATGACTTTTAGCAATGGANAACTAATAGTTAATCAGGATGGC TTTTATTACCTGTATGCCAACATTTGCTTTCGACATCATGAAACTTCAGGAGACCTAGCT ACAGAGTATCTTCAACTAATGGTGTACGTCACTAANACCAGCATCAAAATCCCAGTTCTC ATACCCTGATGAAAGGAGAAGCACCAAGTATTGGTCAGGGAATTCTGAATTCCATTTTTA TTCCATAACGTTGGTGGATTTTTTAAGTTACGGTCTGGAGAGGAATCAGCATCGAGGTCT CCAACCCCTCCTTACTGGATNCGGATCANNGATGCACATACTTTGGNGCNTTTTAAAGTN CGAGATATAGATG >OriGene 3' read for NM_033012 unedited
GCATTGGNATGGCACTTCCAGGNCCAGNAAAGCACTGGGGNAGGGTCACAGGGATGCCAC CCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGATGCATGCTCGAGCG GCCGCCAGTGTGATGGATATCTGCAGAATTCGCCCTTACTCCAAAAACTGGGGCTCAATC TATATCTCGAACTTTAAAAGCCCCAAAGTATGTTGCATCCTGATCCGGATCCAGTAAGGA GGGGTTGGAGACCTCGATGCTGATTTCCTCTCCAGACCGTAACTTAAAAAATCCACCAAC GTTTATGGAATAAAAATGGAATTCAGAATTCCCTGACCAATACTTGGTGCTTCCTCCTTT CATCAGGGTATGAGAACTTGGGATTTTGATGCTGGTTTTAGTGACGTACACCATTAGTTG AAGATACTCTGTAGCTAGGTCTCCTGAAGTTTCATGATGTCGAAAGCAAATGTTGGCATA CAGGTAATAAAAGCCATCCTGATTAACTATTAGTTTTCCATTGCTAANAGTCATGTTGGA GATCTTGGCCCAACCCCGATCATGGTACCAAGAGGACAGACTCACTTTATGGGAACCAGA TGGGATGTCGGTGGCATTAATAGTGAGATGAGCAAAAAGCTGAGCTTTCAGCTTGCTCCT CTTGGCCAGATCTAACCATGAGCCATCCACCATCGCTTTCTCTGCTCTGATGTGCTGTGA TCCCACGATATGTTGTATTCCCTTTTGCACAGCTCCTTGAAGGCCTGTTTAANTCTCCTA CATGAATCAGTATAATTTTGGATACTGACTCTCCAAAGTTGTGGTCTGGAAATCTGCATT TTCATGGAGTCTCAAATTCTATAATGCAGTGAGTGCCATCTTCTGAAATTCTATTAAGAT CCAT |
| Restriction Sites | Please inquire |
| ACCN | NM_033012 |
| Insert Size | 800 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_033012.2, NP_143026.1 |
| RefSeq Size | 1931 bp |
| RefSeq ORF | 735 bp |
| Locus ID | 8600 |
| UniProt ID | O14788 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction |
| Gene Summary | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Differential Expression of the RANKL/RANK/OPG System Is Associated with Bone Metastasis in Human Non-Small Cell Lung Cancer
,null,
PLoS ONE
,PubMed ID 23516466
[TNFSF11]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC224778 | TNFSF11 (Myc-DDK-tagged)-Human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2 |
CNY 2,400.00 |
|
| RC224778L1 | Lenti ORF clone of Human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2, Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC224778L2 | Lenti ORF clone of Human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC224778L3 | Lenti ORF clone of Human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC224778L4 | Lenti ORF clone of Human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG224778 | TNFSF11 (tGFP-tagged) - Human tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 2 |
CNY 4,000.00 |
