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Capicua (CIC) (NM_015125) Human Untagged Clone
CAT＃: SC304239
CIC (untagged)-Human capicua homolog (Drosophila) (CIC)
CNY 31,070.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MRD45 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC304239 representing NM_015125.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGTATTCGGCCCACAGGCCCCTGATGCCCGCGTCCAGCGCGGCCTCCCGTGGCCTCGGCATGTTCGTG TGGACGAATGTGGAACCTCGCTCTGTGGCTGTGTTCCCTTGGCACTCCTTAGTCCCCTTCCTGGCACCC AGCCAGCCTGACCCCTCCGTGCAGCCGAGCGAGGCCCAGCAACCTGCCAGCCACCCAGTGGCCTCCAAC CAGAGCAAAGAACCTGCTGAGTCGGCAGCTGTTGCTCATGAACGGCCACCAGGTGGGACAGGGAGTGCT GACCCTGAGCGGCCCCCTGGAGCCACATGCCCTGAGAGCCCAGGACCCGGACCCCCACACCCTTTGGGG GTGGTGGAATCTGGTAAGGGTCCGCCTCCCACCACGGAGGAGGAGGCCTCCGGCCCCCCAGGAGAGCCC CGGCTGGACAGTGAGACAGAGAGTGACCATGATGATGCCTTCCTCTCCATCATGTCTCCTGAGATCCAG TTGCCTCTACCGCCCGGAAAACGTCGGACCCAGTCCCTCAGTGCCCTACCCAAGGAACGGGACTCATCT TCTGAGAAGGATGGACGCAGCCCCAACAAGCGGGAGAAGGACCACATCCGGCGGCCCATGAATGCCTTC ATGATCTTCAGCAAGCGGCACCGGGCCCTGGTCCACCAGCGTCATCCCAACCAGGACAACCGGACCGTC AGCAAGATCCTGGGCGAGTGGTGGTATGCCCTGGGGCCCAAGGAGAAGCAGAAGTACCACGACCTGGCC TTCCAGGTGAAGGAGGCCCACTTCAAGGCCCACCCAGATTGGAAGTGGTGCAACAAGGACCGAAAGAAG TCCAGCTCAGAGGCCAAGCCCACGAGCCTGGGGCTGGCAGGAGGGCACAAGGAGACGCGGGAGCGGAGC ATGTCGGAGACGGGCACTGCTGCTGCCCCTGGGGTGTCCTCTGAGCTCCTGTCCGTTGCAGCCCAGACA CTCCTGAGCTCAGACACCAAGGCTCCGGGGAGCAGCTCCTGTGGGGCAGAACGGCTACACACAGTTGGG GGACCTGGCTCAGCCCGGCCCCGAGCTTTCTCCCACAGCGGGGTACACAGCCTGGACGGCGGAGAAGTA GACAGTCAGGCGCTACAGGAACTGACGCAGATGGTGTCTGGCCCTGCATCGTACTCTGGCCCAAAGCCT TCTACCCAGTATGGAGCTCCAGGACCCTTTGCAGCCCCTGGTGAGGGAGGTGCCTTGGCGGCCACTGGG CGGCCCCCGCTGCTGCCCACCCGAGCTTCTCGTTCTCAGCGTGCGGCCAGTGAGGACATGACGAGTGAT GAGGAGCGCATGGTCATCTGTGAGGAGGAAGGGGATGATGATGTCATTGCTGACGATGGCTTCGGCACC ACTGACATTGATCTCAAGTGCAAGGAGCGGGTGACCGACAGCGAGAGTGGGGACAGCTCTGGGGAGGAC CCAGAGGGCAACAAGGGCTTTGGTCGGAAGGTGTTTTCACCTGTGATCCGTTCCTCCTTTACCCACTGC CGCCCCCCACTGGACCCTGAGCCCCCAGGGCCCCCGGATCCTCCTGTAGCCTTTGGCAAAGGCTATGGT TCCGCCCCATCCTCCTCTGCGTCCTCGCCTGCTTCCTCCTCAGCCTCGGCAGCCACCTCCTTCTCACTG GGCTCAGGAACCTTCAAGGCCCAGGAGTCTGGTCAGGGCAGCACAGCGGGCCCCCTACGGCCCCCACCC CCTGGGGCTGGGGGTCCAGCGACACCTTCCAAGGCAACCCGGTTCCTCCCAATGGATCCTGCCACCTTC CGGCGCAAGAGACCCGAAAGTGTGGGTGGCCTGGAGCCACCAGGCCCCTCAGTCATCGCGGCCCCTCCC AGCGGAGGAGGAAACATCCTGCAGACACTGGTGCTGCCCCCAAACAAGGAGGAGCAAGAGGGCGGCGGA GCCAGAGTGCCCTCCGCCCCCGCCCCATCACTGGCCTATGGGGCCCCAGCAGCTCCCCTGTCCCGTCCT GCCGCCACCATGGTCACCAATGTGGTGCGGCCTGTCAGCAGCACTCCTGTGCCCATCGCCTCTAAGCCC TTCCCCACCTCTGGCCGGGCTGAGGCGTCTCCAAATGACACAGCAGGTGCCAGGACTGAAATGGGCACT GGGTCTCGGGTGCCTGGGGGCTCCCCGCTGGGTGTCAGCTTAGTGTATTCGGACAAGAAGTCGGCAGCA GCCACCTCACCAGCCCCACACTTGGTGGCTGGACCCCTGCTGGGCACTGTGGGGAAGGCGCCTGCCACT GTCACTAACCTACTGGTGGGCACCCCGGGGTATGGGGCCCCTGCGCCCCCTGCTGTCCAGTTCATTGCC CAGGGGGCCCCTGGTGGTGGGACCACTGCGGGCTCAGGAGCAGGTGCTGGGAGTGGCCCCAATGGGCCA GTACCCCTGGGCATCCTGCAACCAGGTGCCCTGGGCAAGGCTGGGGGAATCACCCAGGTACAGTACATC CTGCCCACGCTGCCCCAGCAGCTTCAGGTGGCACCTGCCCCAGCACCAGCCCCTGGGACCAAGGCAGCG GCTCCCAGCGGCCCTGCACCCACCACCAGCATCCGTTTCACCCTCCCACCGGGCACTTCCACCAACGGC AAAGTCCTGGCTGCCACTGCACCCACTCCTGGCATCCCCATCCTGCAGTCTGTACCCTCCGCCCCACCC CCCAAAGCCCAGTCAGTTTCTCCCGTGCAGGCCCCGCCCCCGGGTGGCTCAGCCCAGCTGCTGCCTGGG AAGGTCCTAGTGCCTCTGGCCGCCCCTAGCATGTCAGTGCGGGGTGGAGGGGCCGGCCAGCCACTGCCA CTGGTGAGCCCGCCCTTCTCAGTACCTGTGCAGAATGGTGCCCAGCCCCCCAGCAAGATCATCCAGCTG ACCCCGGTGCCTGTGAGCACACCCAGCGGCCTGGTGCCGCCCCTGAGCCCAGCCACACTCCCTGGACCC ACCTCTCAGCCTCAGAAGGTCCTGTTGCCCTCCTCCACCAGAATCACCTATGTGCAGTCAGCGGGCGGG CACGCGCTGCCCCTGGGTACCAGCCCTGCGTCCAGCCAGGCTGGAACAGTCACCTCGTACGGGCCCACG AGCTCTGTAGCTCTAGGCTTCACCTCGCTGGGGCCCAGCGGCCCCGCCTTCGTGCAGCCCCTGCTCTCA GCAGGCCAAGCCCCACTGCTGGCTCCCGGTCAGGTGGGCGTGTCACCTGTGCCCAGTCCCCAGCTGCCG CCTGCCTGTGCAGCCCCCGGAGGTCCTGTCATAACAGCATTTTACTCTGGCAGCCCTGCACCCACCTCC TCAGCACCCCTGGCCCAGCCATCCCAGGCCCCCCCAAGCCTGGTCTACACTGTGGCCACCAGCACAACC CCACCTGCAGCCACCATTCTGCCCAAGGGCCCGCCAGCCCCTGCCACTGCCACCCCAGCCCCGACTAGC CCTTTCCCCAGCGCCACAGCAGGTTCCATGACCTACAGCTTAGTGGCCCCCAAGGCCCAGCGGCCCAGC CCGAAGGCCCCCCAGAAAGTGAAGGCAGCCATCGCCAGCATTCCCGTGGGGTCCTTTGAGGCAGGTGCC TCTGGGCGGCCTGGCCCTGCACCCCGGCAGCCTCTGGAGCCTGGCCCAGTCCGAGAGCCAACTGCCCCA GAGTCTGAGCTTGAGGGGCAGCCCACACCACCAGCCCCTCCACCCCTGCCAGAGACCTGGACTCCCACG GCCCGGAGCAGCCCCCCACTGCCCCCACCTGCTGAGGAGCGGACCAGCGCCAAGGGCCCTGAGACCATG GCCAGCAAATTCCCCAGCTCATCTTCAGACTGGCGCGTCCCTGGGCAGGGCCTGGAGAATCGTGGGGAG CCTCCCACTCCTCCCAGCCCGGCCCCAGCTCCAGCTGTAGCCCCTGGTGGCAGCAGCGAGAGCAGCAGT GGGCGGGCAGCCGGGGACACCCCGGAGCGCAAGGAGGCGGCTGGTACTGGCAAGAAGGTGAAGGTGCGG CCCCCGCCCCTGAAGAAGACCTTTGACTCTGTGGACAACAGGGTCCTGTCAGAAGTGGACTTCGAAGAG CGCTTTGCTGAGTTGCCTGAGTTTCGGCCTGAGGAGGTGCTGCCCTCCCCCACCCTGCAGTCTCTGGCC ACCTCACCCCGGGCCATCCTGGGCTCTTACCGCAAGAAGAGGAAGAACTCCACGGACCTGGATTCAGCA CCCGAGGACCCCACCTCGCCCAAGCGCAAGATGAGAAGACGCTCCAGCTGCAGCTCGGAGCCCAACACC CCCAAGAGTGCCAAGTGCGAGGGGGACATCTTCACCTTTGACCGTACAGGTACAGAAGCCGAGGACGTG CTTGGGGAGCTAGAGTATGACAAGGTGCCATACTCCTCCCTGCGGCGCACCCTGGACCAGCGCCGGGCC CTGGTCATGCAGCTCTTTCAGGACCATGGCTTCTTCCCGTCAGCCCAGGCCACAGCCGCCTTCCAGGCC CGCTATGCAGACATCTTTCCCTCCAAGGTTTGTCTGCAGTTGAAGATCCGTGAGGTGCGCCAGAAGATC ATGCAGGCTGCCACTCCCACGGAGCAGCCCCCTGGAGCTGAGGCTCCTCTCCCTGTACCGCCCCCCACT GGCACCGCTGCTGCCCCTGCCCCCACTCCCAGCCCCGCAGGGGGCCCTGACCCCACCTCACCCAGCTCG GACTCTGGCACGGCCCAGGCTGCCCCGCCACTGCCTCCACCCCCAGAGTCGGGGCCTGGACAGCCTGGC TGGGAGGGGGCTCCCCAGCCCTCCCCCCCACCCCCAGGTCCCTCCACAGCTGCCACAGGCAGGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_015125 |
| Insert Size | 4827 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_015125.4 |
| RefSeq Size | 5490 bp |
| RefSeq ORF | 4827 bp |
| Locus ID | 23152 |
| UniProt ID | Q96RK0 |
| MW | 163.8 kDa |
| Gene Summary | The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (CIC-S, PMID:17190598) has a distinct N-terminus and is shorter than isoform CIC-L. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215209 | CIC (Myc-DDK-tagged)-Human capicua homolog (Drosophila) (CIC) |
CNY 16,504.00 |
|
| RC215209L1 | Lenti-ORF clone of CIC (Myc-DDK-tagged)-Human capicua homolog (Drosophila) (CIC) |
CNY 18,904.00 |
|
| RC215209L2 | Lenti-ORF clone of CIC (mGFP-tagged)-Human capicua homolog (Drosophila) (CIC) |
CNY 18,904.00 |
|
| RC215209L3 | Lenti-ORF clone of CIC (Myc-DDK-tagged)-Human capicua homolog (Drosophila) (CIC) |
CNY 17,960.00 |
|
| RC215209L4 | Lenti-ORF clone of CIC (mGFP-tagged)-Human capicua homolog (Drosophila) (CIC) |
CNY 17,960.00 |
|
| RG215209 | CIC (tGFP-tagged) - Human capicua homolog (Drosophila) (CIC) |
CNY 17,670.00 |
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