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KCNH1 (NM_002238) Human Untagged Clone
CAT＃: SC303154
KCNH1 (untagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 1 (KCNH1), transcript variant 2
CNY 10,576.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | EAG; EAG1; h-eag; hEAG; hEAG1; Kv10.1; TMBTS; ZLS1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_002238 edited
CCGAGGCCAGTTTCCTGCTGTCGTAAGAAGCCGCGCCAGGACGCCCGCCGGACCCCGAGC TGCTGGGAGGATGACCATGGCTGGGGGCAGGAGGGGACTAGTGGCCCCTCAAAACACGTT TCTGGAGAATATTGTTCGGCGGTCCAATGATACTAATTTTGTGTTGGGGAATGCTCAGAT AGTGGACTGGCCTATTGTGTACAGCAATGATGGATTTTGCAAGCTGTCTGGCTATCACAG GGCAGAAGTGATGCAAAAAAGCAGCACCTGCAGTTTTATGTATGGGGAGCTGACTGATAA AGACACGATTGAAAAAGTGCGGCAAACATTTGAGAACTATGAGATGAATTCCTTTGAAAT TCTGATGTACAAGAAGAACAGGACACCTGTGTGGTTCTTTGTGAAAATTGCTCCAATTCG AAACGAACAGGATAAAGTGGTTTTATTTCTTTGCACTTTCAGTGACATAACAGCTTTCAA ACAGCCAATTGAGGATGATTCATGTAAAGGCTGGGGGAAGTTTGCTCGGCTGACAAGAGC ACTGACAAGCAGCAGGGGTGTCCTGCAGCAGCTGGCTCCAAGCGTGCAAAAAGGCGAGAA TGTCCACAAGCACTCCCGCCTGGCAGAGGTCCTACAGCTGGGCTCAGACATCCTTCCCCA GTACAAGCAAGAGGCACCAAAGACTCCCCCTCACATCATCTTACATTATTGTGTTTTTAA GACCACGTGGGATTGGATCATCTTGATCTTGACCTTCTATACAGCCATCTTGGTCCCTTA TAATGTCTCCTTCAAAACCAGGCAGAATAATGTGGCCTGGCTGGTTGTTGATAGCATCGT GGATGTTATCTTTTTGGTGGACATTGTGCTCAATTTTCATACCACCTTTGTTGGACCAGC AGGGGAGGTGATTTCTGACCCCAAACTTATCCGCATGAACTACCTGAAGACGTGGTTTGT GATTGACCTTCTGTCCTGTTTGCCATATGATGTCATCAACGCTTTTGAGAACGTGGATGA GGGCATCAGCAGCCTGTTCAGCTCTCTAAAAGTTGTCCGGCTGCTCCGTCTTGGGCGAGT GGCCCGTAAGCTGGACCACTACATTGAATATGGAGCTGCTGTGCTGGTCCTGCTGGTGTG TGTGTTTGGGCTGGCTGCACACTGGATGGCCTGCATCTGGTACAGCATTGGGGACTATGA GATCTTTGACGAGGACACCAAGACAATCCGCAACAACAGCTGGCTGTACCAACTAGCGAT GGACATTGGCACCCCTTACCAGTTTAATGGGTCTGGCTCAGGGAAGTGGGAAGGTGGTCC CAGCAAGAATTCTGTCTACATCTCCTCGTTGTATTTCACAATGACCAGCCTCACCAGTGT GGGCTTTGGGAACATCGCCCCATCCACAGACATTGAGAAGATCTTTGCAGTGGCCATCAT GATGATTGGCTCACTTCTCTATGCCACCATCTTCGGGAATGTGACGACTATTTTCCAACA GATGTATGCCAACACCAACAGATACCATGAGATGCTCAACAGTGTTCGGGACTTCCTGAA GCTCTACCAGGTGCCAAAAGGATTGAGTGAGCGAGTAATGGATTATATTGTGTCCACTTG GTCCATGTCCAGAGGCATTGACACAGAGAAGGTCCTGCAGATCTGCCCCAAGGACATGAG AGCCGACATCTGCGTGCACCTGAACCGCAAGGTGTTCAAGGAGCACCCGGCCTTCCGGCT GGCCAGTGATGGCTGCCTCCGGGCACTGGCCATGGAGTTCCAGACGGTGCACTGTGCCCC AGGGGACCTCATCTACCATGCAGGAGAGAGCGTTGACAGCCTCTGCTTTGTGGTTTCTGG CTCCCTGGAGGTGATCCAAGATGATGAGGTGGTGGCCATTCTAGGAAAAGGAGACGTGTT TGGAGATGTGTTCTGGAAGGAAGCCACCCTTGCCCAGTCCTGTGCCAATGTTAGGGCCTT GACCTACTGTGATCTGCATGTGATCAAGCGGGATGCCCTGCAGAAAGTGCTGGAATTCTA CACGGCCTTCTCCCATTCCTTCTCCCGGAACCTGATTCTGACGTACAACTTGAGGAAGAG GATTGTGTTCCGGAAGATCAGCGACGTGAAACGTGAAGAGGAAGAACGCATGAAACGAAA GAATGAGGCCCCCCTGATCTTGCCCCCGGACCACCCTGTCCGGCGCCTCTTCCAGAGATT CCGACAGCAGAAAGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGACCTGGATGACCT AGATGTGGAGAAGGGCAATGTCCTTACAGAGCATGCCTCCGCCAACCACAGCCTCGTGAA GGCCAGCGTGGTCACCGTGCGTGAGAGTCCTGCCACGCCCGTATCCTTCCAGGCAGCCTC CACCTCCGGGGTGCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAGTGCCTGGGCCC CAAGGGGGGCGGGGGCGATTGTGCCAAGCGCAAAAGCTGGGCCCGCTTCAAAGATGCTTG CGGGAAGAGTGAGGACTGGAACAAGGTGTCCAAGGCTGAGTCGATGGAGACACTTCCCGA GAGGACAAAAGCGTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGTGACAGTGGCAT CACCAAGAGCGACTTGCGCCTGGACAACGTGGGTGAGGCCAGGAGTCCCCAGGATCGGAG TCCCATCCTGGCAGAGGTCAAGCATTCGTTCTACCCCATCCCTGAGCAGACGCTGCAGGC CACAGTCCTGGAGGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTAAACGCCAAAAT GACCAATATTGAGAAACAGCTCTCTGAGATACTCAGGATATTAACTTCCAGAAGATCCTC TCAGTCTCCTCAGGAGTTGTTTGAAATATCGAGGCCACAGTCCCCAGAATCAGAGAGAGA CATTTTTGGAGCCAGCTGAGAGGTCTATTTAAAAAAACAGTCAGAGACAGATACCTACAA CCCTGCCGTC >OriGene 5' read for NM_002238 unedited
GAGACTGTTGTAATACGACTCCTATAGGGCGGCCGCGAATTCGCCCTTCCGAGGCCAGTT TCCTGCTGTCGTAAGAAGCCGCGCCAGGACGCCCGCCGGACCCCGAGCTGCTGGGAGGAT GACCATGGCTGGGGGCAGGAGGGGACTAGTGGCCCCTCAAAACACGTTTCTGGAGAATAT TGTTCGGCGGTCCAATGATACTAATTTTGTGTTGGGGAATGCTCAGATAGTGGACTGGCC TATTGTGTACAGCAATGATGGATTTTGCAAGCTGTCTGGCTATCACAGGGCAGAAGTGAT GCAAAAAAGCAGCACCTGCAGTTTTATGTATGGGGAGCTGACTGATAAAGACACGATTGA AAAAGTGCGGCAAACATTTGAGAACTATGAGATGAATTCCTTTGAAATTCTGATGTACAA GAAGAACAGGACACCTGTGTGGTTCTTTGTGAAAATTGCTCCAATTCGAAACGAACAGGA TAAAGTGGTTTTATTTCTTTGCACTTTCAGTGACATAACAGCTTTCAAACAGCCAATTGA GGATGATTCATGTAAAGGCTGGGGGAAGTTTGCTCGGCTGACAAGAGCACTGACAAGCAG CAGGGGTGTCCTGCAGCAGCTGGCTCCAAGCGTGCAAAAAGGCGAGAATGTCCACAAGCA CTCCCGCCTGGCAGAGGTCCTACAGCTGGGCTCAGACATCCTTCCCCAGTACAAGCAAGA GCACCAAAGACTCCCCCTCACATCATCTTACATTATTGTGTTTTTAAGACCACGTGGGAT TGGATCATCTTGATCTTGACCTTCTATACAGCCATCTTGGTCCCTTATATGTCTCCTTCA AACCAGGCAGATATGTGCCTGCTGTTGTTGATAGCATCGTGGATGTTATCTTTTTGGTGG ACATTGTGCCTCAATTTTCATACCACCCTTTGTTGGACCAGCAGGGGAGGTGAT |
| Restriction Sites | Please inquire |
| ACCN | NM_002238 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002238.2, NP_002229.1 |
| RefSeq Size | 3127 bp |
| RefSeq ORF | 2889 bp |
| Locus ID | 3756 |
| UniProt ID | O95259 |
| Protein Families | Druggable Genome, Ion Channels: Potassium, Transmembrane |
| Gene Summary | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2), also known as eag, lacks an alternate in-frame segment, as compared to variant 1. It encodes isoform 2, which is shorter but has the same N- and C-termini as isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
5-Chloro-2-Guanidinobenzimidazole (ClGBI) Is a Non-Selective Inhibitor of the Human H V 1 Channel
,null,
Pharmaceuticals
,PubMed ID 37242439
[KCNH1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215104 | KCNH1 (Myc-DDK-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 1 (KCNH1), transcript variant 2 |
CNY 10,568.00 |
|
| RC215104L1 | Lenti ORF clone of Human potassium voltage-gated channel, subfamily H (eag-related), member 1 (KCNH1), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC215104L2 | Lenti ORF clone of Human potassium voltage-gated channel, subfamily H (eag-related), member 1 (KCNH1), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC215104L3 | Lenti ORF clone of Human potassium voltage-gated channel, subfamily H (eag-related), member 1 (KCNH1), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC215104L4 | Lenti ORF clone of Human potassium voltage-gated channel, subfamily H (eag-related), member 1 (KCNH1), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG215104 | KCNH1 (tGFP-tagged) - Human potassium voltage-gated channel, subfamily H (eag-related), member 1 (KCNH1), transcript variant 2 |
CNY 4,370.00 |
