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GNA11 (NM_002067) Human Untagged Clone
CAT＃: SC303115
GNA11 (untagged)-Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11)
CNY 3,656.00
CNY 7,220.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | FBH; FBH2; FHH2; GNA-11; HHC2; HYPOC2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_002067 edited
ATGACTCTGGAGTCCATGATGGCGTGTTGCCTGAGCGATGAGGTGAAGGAGTCCAAGCGG ATCAACGCCGAGATCGAGAAGCAGCTGCGGCGGGACAAGCGCGACGCCCGGCGCGAGCTC AAGCTGCTGCTGCTCGGCACGGGCGAGAGCGGGAAGAGCACGTTCATCAAGCAGATGCGC ATCATCCACGGCGCCGGCTACTCGGAGGAGGACAAGCGCGGCTTCACCAAGCTCGTCTAC CAGAACATCTTCACCGCCATGCAGGCCATGATCCGGGCCATGGAGACGCTCAAGATCCTC TACAAGTACGAGCAGAACAAGGCCAATGCGCTCCTGATCCGGGAGGTGGACGTGGAGAAG GTGACCACCTTCGAGCATCAGTACGTCAGTGCCATCAAGACCCTGTGGGAGGACCCGGGC ATCCAGGAATGCTACGACCGCAGGCGCGAGTACCAGCTCTCCGACTCTGCCAAGTACTAC CTGACCGACGTTGACCGCATCGCCACCTTGGGCTACCTGCCCACCCAGCAGGACGTGCTG CGGGTCCGCGTGCCCACCACCGGCATCATCGAGTACCCTTTCGACCTGGAGAACATCATC TTCCGGATGGTGGATGTGGGGGGCCAGCGGTCGGAGCGGAGGAAGTGGATCCACTGCTTT GAGAACGTGACATCCATCATGTTTCTCGTCGCCCTCAGCGAATACGACCAAGTCCTGGTG GAGTCGGACAACGAGAACCGGATGGAGGAGAGCAAAGCCCTGTTCCGGACTATCATCACC TACCCCTGGTTCCAGAACTCCTCCGTCATCCTCTTCCTCAACAAGAAGGACCTGCTGGAG GACAAGATCCTGTACTCGCACCTGGTGGACTACTTCCCCGAGTTCGATGGTCCCCAGCGG GACGCCCAGGCGGCGCGGGAGTTCATCCTGAAGATGTTCGTGGACCTGAACCCCGACAGC GACAAGATCATCTACTCACACTTCACGTGTGCCACCGACACGGAGAACATCCGCTTCGTG TTCGCGGCCGTGAAGGACACCATCCTGCAGCTCAACCTCAAGGAGTACAACCTGGTCTGA GCGCCCAGGCCCAGGGAGACGGGATGGAGACACGGGGCAGGACCTTCCTTCCACGGAGCC TGCGGCTGCCGGGCGGGTGGCGCTGCCGAGTCCGGGCCGGGGCCTCTGCCCGCGGGAGGA GATTTTTTTTTTTCATATTTTTAACAAATGGTTTTTATTTCACAGTTATCAGGGGATGTA CATCTCTCCCTCCGTACACTTCGCGCACCTTCTCACCTTTTGTCAACGGCAAAGGCAGCC TTTTTCTGGCCTTGACTTATGGCTCGCTTTTTTCTAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_002067 unedited
GTCAAAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGATGACTCTGG AGTCCATGATGGCGTGTTGCCTGAGCGATGAGGTGAAGGAGTCCAAGCGGATCAACGCCG AGATCGAGAAGCAGCTGCGGCGGGACAAGCGCGACGCCCGGCGCGAGCTCAAGCTGCTGC TGCTCGGCACGGGCGAGAGCGGGAAGAGCACGTTCATCAAGCAGATGCGCATCATCCACG GCGCCGGCTACTCGGAGGAGGACAAGCGCGGCTTCACCAAGCTCGTCTACCAGAACATCT TCACCGCCATGCAGGCCATGATCCGGGCCATGGAGACGCTCAAGATCCTCTACAAGTACG AGCAGAACAAGGCCAATGCGCTCCTGATCCGGGAGGTGGACGTGGAGAAGGTGACCACCT TCGAGCATCAGTACGTCAGTGCCATCAAGACCCTGTGGGAGGACCCGGGCATCCAGGAAT GCTACGACCGCAGGCGCGAGTACCAGCTCTCCGACTCTGCCAAGTACTACCTGACCGACG TTGACCGCATCGCCACCTTGGGCTACCTGCCCACCCAGCAGGACGTGCTGCGGGTCCGCG TGCCCACCACCGGCATCATCGAGTACCCTTTCGACCTGGAGAACATCATCTTCCGGATGG TGGATGTGGGGGGCCAGCGGTCGGAGCGGAGGAAGTGGATCCACTGCTTTGAGAACGTGA CATCCATCATGTTTCTCGTCGCCCTCAGCGAATACGACCAAGTCCTGGTGGAGTCNGACA ACGAGAACCGGATGGGAGGAGAGCAAGCCCTGTTCCGGACTATCATCACCTACCCCTGGT TCCAGAACTNCTNCGTCATCCTCTTTCTCAACAGAAGGACCTGCTGNAGGACAGATCCTG TACTCGCACN >OriGene 3' read for NM_002067 unedited
CCCATTGAGATGGCACTTCCAGGTCCAGNAAAGCACTGGGGNAGGGTCACAGGGATGCCA CCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTT TTTTTTTTTTTAGAAAAAAGCGAGCCATAAGTCAAGGCCAGAAAAAGGCTGCCTTTGCCG TTGACAAAAGGTGAGAAGGTGCGCGAAGTGTACGGAGGGAGAGATGTACATCCCCTGATA ACTGTGAAATAAAAACCATTTGTTAAAAATATGAAAAAAAAAAATCTCCTCCCGCGGGCA GAGGCCCCGGCCCGGACTCGGCAGCGCCACCCGCCCGGCAGCCGCAGGCTCCGTGGAAGG AAGGTCCTGCCCCGTGTCTCCATCCCGTCTCCCTGGGCCTGGGCGCTCAGACCAGGTTGT ACTCCTTGAGGTTGAGCTGCAGGATGGTGTCCTTCACGGCCGCGAACACGAAGCGGATGT TCTCCGTGTCGGTGGCACACGTGAAGTGTGAGTAGATGATCTTGTCGCTGTCGGGGTTCA GGTCCACGAACATCTTCAGGATGAACTCCCGCGCCGCCTGGGCGTCCCGCTGGGGACCAT CGAACTCGGGGAAGTAGTCCACCAGGTGCGAGTACAGGATCTTGTCCTCCAGCAGGTCCT TCTTGTTGAGGAAGAGGATGACGGGAGAGTTCTGGAACCAGGGGTAGGTGATGATAGTCC GGAACAGGGCTTTGCTCTCCTCCATCCGGTTCTCGTTGTCCGACTCCACCAGACTTGGTC GTATTCGCTGAAGGCGACCAGGAACATGATGGATGTCACGTTCTAAAGCAGGGGATCCAT TTCTTCGGTTCGACCGTTTGGCCCCCCACTTCACCATTCGGAAGATGTTGTTCTCCAGGT CGAAAGGTTCTC |
| Restriction Sites | Please inquire |
| ACCN | NM_002067 |
| Insert Size | 1400 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002067.1, NP_002058.1 |
| RefSeq Size | 1540 bp |
| RefSeq ORF | 1080 bp |
| Locus ID | 2767 |
| UniProt ID | P29992 |
| Protein Pathways | Calcium signaling pathway, Gap junction, GnRH signaling pathway, Long-term depression, Vascular smooth muscle contraction |
| Gene Summary | The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Mosaic activating mutations in GNA11 and GNAQ are associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis
,Thomas, AC;Zeng, Z;Rivière, JB;O'Shaughnessy, R;Al-Olabi, L;St-Onge, J;Atherton, DJ;Aubert, H;Bagazgoitia, L;Barbarot, S;Bourrat, E;Chiaverini, C;Chong, WK;Duffourd, Y;Glover, M;Groesser, L;Hadj-Rabia, S;Hamm, H;Happle, R;Mushtaq, I;Lacour, JP;Waelchli, R,
J. Invest. Dermatol.
,PubMed ID 26778290
[GNA11]
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|
The KDEL receptor couples to Gaq/11 to activate Src kinases and regulate transport through the Golgi
,Monica Giannotta, Carmen Ruggiero, Mauro Grossi, Jorge Cancino, Mirco Capitani,,
The EMBO Journal doi:10.1038/emboj.2012.134
[GNA11]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210292 | GNA11 (Myc-DDK-tagged)-Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11) |
CNY 3,656.00 |
|
| RC210292L1 | Lenti ORF clone of Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC210292L2 | Lenti ORF clone of Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11), mGFP tagged |
CNY 5,890.00 |
|
| RC210292L3 | Lenti ORF clone of Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC210292L4 | Lenti ORF clone of Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11), mGFP tagged |
CNY 5,890.00 |
|
| RG210292 | GNA11 (tGFP-tagged) - Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11) |
CNY 5,256.00 |
