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Shugoshin (SGO1) (NM_001012409) Human Untagged Clone
CAT＃: SC301641
SGOL1 (untagged)-Human shugoshin-like 1 (S. pombe) (SGOL1), transcript variant A1
CNY 8,460.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CAID; NY-BR-85; SGO; SGOL1 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001012409, the custom clone sequence may differ by one or more nucleotides
ATGGCCAAGGAAAGATGCCTGAAAAAGTCCTTTCAAGATAGTCTTGAAGACATAAAGAAG CGAATGAAAGAGAAAAGGAATAAAAACTTGGCAGAGATTGGCAAACGCAGGTCTTTTATA GCTGCACCATGCCAAATAATCACCAACACTTCTACACTGCTGAAAAATTACCAAGACAAC AACAAAATGTTAGTTTTAGCTTTGGAAAATGAAAAATCCAAAGTGAAAGAAGCCCAAGAT ATCATCCTACAGCTGAGAAAAGAATGTTACTATCTCACATGTCAGCTATATGCATTGAAA GGAAAACTTACATCACAACAAACAGTAGAACCTGCTCAGAACCAGGAAATATGTTCCTCT GGAATGGACCCCAATAGTGATGACAGCTCCAGAAATTTATTTGTGAAGGATTTACCGCAA ATTCCTCTTGAAGAAACTGAACTTCCAGGACAAGGAGAATCATTTCAAATAGAAGATCAG ATACCTACTATTCCTCAAGACACACTGGGAGTTGATTTTGATTCAGGTGAAGCTAAGTCT ACTGATAATGTCTTACCTAGAACTGTATCTGTTCGTAGCAGTTTAAAGAAACATTGTAAC AGTATATGTCAGTTTGATAGCTTGGATGATTTTGAAACCAGTCATTTGGCAGGGAAGTCT TTTGAATTCGAAAGAGTTGGATTTTTAGACCCACTAGTAAACATGCACATACCTGAAAAT GTACAACACAATGCTTGTCAATGGAGCAAGGACCAAGTTAACTTATCACCAAAGCTGATT CAGCCAGGAACGTTTACTAAAACAAAAGAAGACATTTTAGAATCTAAATCTGAACAAACT AAAAGTAAGCAAAGAGATACACAAGAAAGAAAAAGAGAAGAGAAAAGAAAAGCTAACAGG AGAAAATCAAAACGTATGTCAAAATATAAAGAGAATAAAAGCGAAAATAAAAAAACTGTT CCCCAAAAAAAAATGCACAAATCTGTCAGTTCCAATGATGCTTACAATTTTAATTTGGAA GAGGGTGTTCATCTTACTCCTTTCCGACAAAAAGTGAGCAATGACTCTAATAGAGAAGAA AACAACGAGTCTGAAGTGAGCCTCTGTGAATCAAGTGGTTCAGGAGATGATTCCGATGAC CTCTATTTGCCCACTTGCAAGTACATTCAGAATCCCACGAGCAATTCAGATAGACCAGTC ACCAGGCCTCTAGCTAAAAGAGCACTGAAATACACAGATGAAAAAGAGACGGAGGGTTCT AAGCCAACAAAAACTCCTACCACTACACCACCTGAAACTCAGCAGTCACCTCATCTTAGC CTGAAGGATATCACCAATGTCTCCTTGTATCCTGTTGTGAAAATCAGAAGACTTTCTCTT TCTCCAAAAAAGAATAAAGCAAGCCCAGCAGTGGCTCTGCCTAAACGTAGGTGCACAGCC AGCGTGAACTATAAGGAGCCCACCCTCGCTTCGAAACTGAGAAGAGGGGACCCTTTTACA GATTTGTGTTTTTTGAATTCTCCTATTTTCAAGCAGAAAAAGGATTTGAGACGTTCTAAA AAAAGTATGAAACAAATACAATGA |
| Restriction Sites | Please inquire |
| ACCN | NM_001012409 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001012409.1, NP_001012409.1 |
| RefSeq Size | 1956 bp |
| RefSeq ORF | 1584 bp |
| Locus ID | 151648 |
| UniProt ID | Q5FBB7 |
| Protein Pathways | Oocyte meiosis |
| Gene Summary | The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] Transcript Variant: This variant (A1) differs in the 5' UTR compared to variant 1. Both variants 1 and A1 encode the same isoform (1). |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC214977 | SGOL1 (Myc-DDK-tagged)-Human shugoshin-like 1 (S. pombe) (SGOL1), transcript variant A1 |
CNY 3,928.00 |
|
| RC214977L3 | Lenti-ORF clone of SGOL1 (Myc-DDK-tagged)-Human shugoshin-like 1 (S. pombe) (SGOL1), transcript variant A1 |
CNY 6,460.00 |
|
| RC214977L4 | Lenti-ORF clone of SGOL1 (mGFP-tagged)-Human shugoshin-like 1 (S. pombe) (SGOL1), transcript variant A1 |
CNY 6,460.00 |
|
| RG214977 | SGOL1 (tGFP-tagged) - Human shugoshin-like 1 (S. pombe) (SGOL1), transcript variant A1 |
CNY 5,040.00 |
