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HNF1 alpha (HNF1A) (NM_000545) Human Untagged Clone
CAT＃: SC300093
HNF1A (untagged)-Human HNF1 homeobox A (HNF1A)
CNY 7,056.00
| Cited in 4 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HNF-1A; HNF1; HNF1alpha; HNF4A; IDDM20; LFB1; MODY3; TCF-1; TCF1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000545 edited
CGTGGCCCTGTGGCAGCCGAGCCATGGTTTCTAAACTGAGCCAGCTGCAGACGGAGCTCC TGGCGGCCCTGCTCGAGTCAGGGCTGAGCAAAGAGGCACTGATCCAGGCACTGGGTGAGC CGGGGCCCTACCTCCTGGCTGGAGAAGGCCCCCTGGACAAGGGGGAGTCCTGCGGCGGCG GTCGAGGGGAGCTGGCTGAGCTGCCCAATGGGCTGGGGGAGACTCGGGGCTCCGAGGACG AGACGGACGACGATGGGGAAGACTTCACGCCACCCATCCTCAAAGAGCTGGAGAACCTCA GCCCTGAGGAGGCGGCCCACCAGAAAGCCGTGGTGGAGACCCTTCTGCAGGAGGACCCGT GGCGTGTGGCGAAGATGGTCAAGTCCTACCTGCAGCAGCACAACATCCCACAGCGGGAGG TGGTCGATACCACTGGCCTCAACCAGTCCCACCTGTCCCAACACCTCAACAAGGGCACTC CCATGAAGACGCAGAAGCGGGCCGCCCTGTACACCTGGTACGTCCGCAAGCAGCGAGAGG TGGCGCAGCAGTTCACCCATGCAGGGCAGGGAGGGCTGATTGAAGAGCCCACAGGTGATG AGCTACCAACCAAGAAGGGGCGGAGGAACCGTTTCAAGTGGGGCCCAGCATCCCAGCAGA TCCTGTTCCAGGCCTATGAGAGGCAGAAGAACCCTAGCAAGGAGGAGCGAGAGACGCTAG TGGAGGAGTGCAATAGGGCGGAATGCATCCAGAGAGGGGTGTCCCCATCACAGGCACAGG GGCTGGGCTCCAACCTCGTCACGGAGGTGCGTGTCTACAACTGGTTTGCCAACCGGCGCA AAGAAGAAGCCTTCCGGCACAAGCTGGCCATGGACACGTACAGCGGGCCCCCCCCAGGGC CAGGCCCGGGACCTGCGCTGCCCGCTCACAGCTCCCCTGGCCTGCCTCCACCTGCCCTCT CCCCCAGTAAGGTCCACGGTGTGCGCTATGGACAGCCTGCGACCAGTGAGACTGCAGAAG TACCCTCAAGCAGCGGCGGTCCCTTAGTGACAGTGTCTACACCCCTCCACCAAGTGTCCC CCACGGGCCTGGAGCCCAGCCACAGCCTGCTGAGTACAGAAGCCAAGCTGGTCTCAGCAG CTGGGGGCCCCCTCCCCCCTGTCAGCACCCTGACAGCACTGCACAGCTTGGAGCAGACAT CCCCAGGCCTCAACCAGCAGCCCCAGAACCTCATCATGGCCTCACTTCCTGGGGTCATGA CCATCGGGCCTGGTGAGCCTGCCTCCCTGGGTCCTACGTTCACCAACACAGGTGCCTCCA CCCTGGTCATCGGCCTGGCCTCCACGCAGGCACAGAGTGTGCCGGTCATCAACAGCATGG GCAGCAGCCTGACCACCCTGCAGCCCGTCCAGTTCTCCCAGCCGCTGCACCCCTCCTACC AGCAGCCGCTCATGCCACCTGTGCAGAGCCATGTGACCCAGAGCCCCTTCATGGCCACCA TGGCTCAGCTGCAGAGCCCCCACGCCCTCTACAGCCACAAGCCCGAGGTGGCCCAGTACA CCCACACGGGCCTGCTCCCGCAGACTATGCTCATCACCGACACCACCAACCTGAGCGCCC TGGCCAGCCTCACGCCCACCAAGCAGGTCTTCACCTCAGACACTGAGGCCTCCAGTGAGT CCGGGCTTCACACGCCGGCATCTCAGGCCACCACCCTCCACGTCCCCAGCCAGGACCCTG CCGGCATCCAGCACCTGCAGCCGGCCCACCGGCTCAGCGCCAGCCCCACAGTGTCCTCCA GCAGCCTGGTGCTGTACCAGAGCTCAGACTCCAGCAATGGCCAGAGCCACCTGCTGCCAT CCAACCACAGCGTCATCGAGACCTTCATCTCCACCCAGATGGCCTCTTCCTCCCAGTAAC CACGGCACCTGGGCCCTGGGGCCTGTACTGCCTGCTTGGGGGGTGATGAGGGCAGCAGCC AGCCCTGCCTGGAGGACCTGAGCCTGCCGAGCAACCGTGGCCCTTCCTGGACAGCTGTGC CTCGCTCCCCACTCTGCTCTGATGCATCAGAAAGGGAGGGCTCTGA >OriGene 5' read for NM_000545 unedited
GGGCTCAGATTTGTAAACGACTTATATAGGGCGGCCGCGAATCCGAGCCATGGTTTCTAA ACTGAGCCAGCTGCAGACGGAGCTCCTGGCGGCCCTGCTCGAGTCAGGGCTGAGCAAAGA GGCACTGATCCAGGCACTGGGTGAGCCGGGGCCCTACCTCCTGGCTGGAGAAGGCCCCCT GGACAAGGGGGAGTCCTGCGGCGGCGGTCGAGGGGAGCTGGCTGAGCTGCCCAATGGGCT GGGGGAGACTCGGGGCTCCGAGGACGAGACGGACGACGATGGGGAAGACTTCACGCCACC CATCCTCAAAGAGCTGGAGAACCTCAGCCCTGAGGAGGCGGCCCACCAGAAAGCCGTGGT GGAGACCCTTCTGCAGGAGGACCCGTGGCGTGTGGCGAAGATGGTCAAGTCCTACCTGCA GCAGCACAACATCCCACAGCGGGAGGTGGTCGATACCACTGGCCTCAACCAGTCCCACCT GTCCCAACACCTCAACAAGGGCACTCCCATGAAGACGCAGAAGCGGGCCGCCCTGTACAC CTGGTACGTCCGCAAGCAGCGAGAGGTGGCGCAGCAGTTCACCCATGCAGGGCAGGGAGG GCTGATTGAAGAGCCCACAGGTGATGAGCTACCAACCAAGAAGGNGCGGAGGAACCGTTT CAAGTGGGGCCCAGCATCCCAGCAGATCCTGTTCCAGGCCTATGAGAGGCAGAAGAACCC TAGCAAGGAGAGCGAGAGACGCTAGTGGAGGAGTGCAATAGGGCGGAATGCATCCAGAGA GGGGTGGTCCCATCACAGGCACAGGGGCTGGGGCTCAACCTCGTCACGGGAGTGCGTGTC TACAACTGGTTTGGCACCGGCGCAAAGAAGAAGCCTTTCCGCCCAAGCTGGCCCTGGAC >OriGene 3' read for NM_000545 unedited
CCACGTAGACTGCGCCTCGCAAGCTAGGTACAGCACCGTGGATAGGGTTCACAAGGTACT CACATCGGCATCGGTGTACGAATCAANAGCCCTCCCTTTCTGATGCATCAGAGCAGAGTG GGGAGCGAGGCACAGCTGTCCAGGAAGGGCCACGGTTGCTCGGCAGGCTCATGTCCTCCA GGCACGGCTGGCTGCTGCCCTCATCACCCCCCAAGCAGGCAGTACAGGCCCCAGGGCCCA CGTGCCGTGGTTACTGGGAGGAAGAGGCCATCTGGGTGGAGATGAAGGTCTCGATGACGC TGTGGTTGGATGGCAGCAAGTGGCTCTGGCCATTGCTGGAGTCTGACCTCTGGTACAGCA CCAGGCTGCTGGAGGACACTGTGGGGCTGGCGCTGAGCCGGTGGGCCGGCTGCAGGTGCT GGATGCCTGCAGGGTCCTGGCTGGCGACTTGAAGGGTGGTGGCCTGAGATGCCGGCCTGT GAAGCCCGGACTCACTGGAGGCCTCACTGTCTGACGTGAACACCTGCTTGGTGGGCGTGA GGCTGGCCATGGCGCTCAGGTTGGTGGTGTCTGTGATGAGCATACTCTGCGTGAGCAGGC ACCTGTGTGTGTACTGTGCCACCTCGGGCTTGTGGCTGTATAGGGCGTGGCGGCTCTGCA ACTGATCCATGGTGGCCATCGAAGGGGCTCTGGGGTCACATCGACTCTGCACATGTGGCA TTGACCGGCTCGCTGGTACGTATGGGTGCCAACCGCTGGGGAGAACTTGAACCGGGCTGC AGGGTGGATCAGGGCTGCTGCCCATGCTGGTTGATGACCCGGCACAACTCTGTGGCTTGC CTTGAAGGGCCAGAACCCATGACCCATGGGTGGAAGGCCACCGGGGGTGGTTGGAAACGT CAGGACCCAAGGGGAGGCCAAGCTTCACCAGCCCCCCATGGTGCCATAA |
| Restriction Sites | Please inquire |
| ACCN | NM_000545 |
| Insert Size | 2100 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000545.3, NP_000536.3 |
| RefSeq Size | 3249 bp |
| RefSeq ORF | 1896 bp |
| Locus ID | 6927 |
| UniProt ID | P20823 |
| Protein Families | Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors |
| Protein Pathways | Maturity onset diabetes of the young |
| Gene Summary | The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Hepatocyte nuclear factor 1 alpha influences pancreatic cancer growth and metastasis
,null,
Scientific Reports
,PubMed ID 33214606
[HNF1A]
|
|
Transcriptional regulation of human organic anion transporter 1 (OAT1) by B-cell CLL/lymphoma 6 (BCL6)
,Wegner, W;Burckhardt, G;Henjakovic, M;,
Am. J. Physiol. Renal Physiol.
,PubMed ID 25234312
[HNF1A]
|
|
Direct Reprogramming of Human Fibroblasts to Hepatocyte-Like Cells by Synthetic Modified mRNAs
,Simeonov, KP;Uppal, H;,
PLoS ONE
,PubMed ID 24963715
[HNF1A]
|
|
The transcription factor HNF1α induces expression of angiotensin-converting enzyme 2 (ACE2) in pancreatic islets from evolutionarily conserved promoter motifs
,null,
Biochimica et biophysica acta
,PubMed ID 24100303
[HNF1A]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC211201 | HNF1A (Myc-DDK-tagged)-Human HNF1 homeobox A (HNF1A) |
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| RC211201L1 | Lenti ORF clone of Human HNF1 homeobox A (HNF1A), Myc-DDK-tagged |
CNY 9,448.00 |
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| RC211201L2 | Lenti ORF clone of Human HNF1 homeobox A (HNF1A), mGFP tagged |
CNY 9,448.00 |
|
| RC211201L3 | Lenti ORF clone of Human HNF1 homeobox A (HNF1A), Myc-DDK-tagged |
CNY 9,448.00 |
|
| RC211201L4 | Lenti ORF clone of Human HNF1 homeobox A (HNF1A), mGFP tagged |
CNY 9,448.00 |
|
| RG211201 | HNF1A (tGFP-tagged) - Human HNF1 homeobox A (HNF1A) |
CNY 8,648.00 |
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